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111.
Grove M Vonsattel JP Mazzoni P Marder K 《Science of aging knowledge environment : SAGE KE》2003,2003(43):dn3
In this case study, we describe the symptoms, neurological exam, neuropsychological test results, and brain pathology of a man who died with Huntington's disease (HD). HD is a rare neurodegenerative disease. Like other movement disorders involving the basal ganglia, HD affects motor, cognitive, and psychiatric functioning. The disease follows an autosomal dominant pattern of inheritance, with onset of symptoms most commonly occurring in the late 30s or early 40s, as in this patient. HD is caused by an unstable expansion of the trinucleotide CAG, coding for glutamine, on chromosome 4. Despite knowledge of the gene mutation responsible for HD, no definitive treatment is currently available to slow or halt progression of the disease. However, symptomatic treatment can significantly improve the quality of life for patients with HD. 相似文献
112.
Protecting and conserving environmental resources is a global concern. Over the past decade, a number of certification processes have emerged to help designers and operators of buildings assess the potential impact of a building on the environment. Certifications such as the Leadership in Energy and Environmental Design (LEED) consider the environmental impact through the lifecycle of a building, but may not be considering the people that construct and utilize it. It is important to remember the human factor. Considering the human factor throughout the lifecycle is crucial to ensure individuals are protected during construction and in operation in the built environment. The paper highlights how ergonomics can be integrated into the life cycle of a building to promote sustainability goals for both the human factor and the environment. A case study approach will be used to illustrate how ergonomics was integrated into a LEED renovation and expanded into its daily operations on a large university campus.. 相似文献
113.
预期寿命增长、年龄结构改变与我国国民储蓄率 总被引:1,自引:0,他引:1
人口年龄结构趋于老龄化和人均预期寿命逐步增长是目前我国人口发展的两个典型特征,而年龄阶段不同,个人的收入、消费与储蓄行为也不同。基于生命周期理论,在选定相关分析指标的基础上,文章使用我国省际平衡面板数据,实证分析了我国人口预期寿命增长和年龄结构改变对国民储蓄率的影响。分析结论表明,人口预期寿命增长提高了我国国民储蓄率;不考虑时间效应时,幼年人口负担比提高会减少国民储蓄率,而老年人口负担比提高会增加国民储蓄率;在考虑时间效应时,幼年人口负担比提高会增加国民储蓄率,而老年人口负担比提高会减少国民储蓄率。对此,文章给出了合理的解释。通过使用多种估计方法,我们发现所得到的结论是基本稳健的。 相似文献
114.
Anna R. Bergdall Joan Marie Kraft Karen Andes Marion Carter Kendra Hatfield-Timajchy Linda Hock-Long 《Journal of sex research》2013,50(6):570-582
Communication technology is a central feature of young people's lives, but its role in romantic and sexual relationships has not been thoroughly examined. This article describes how young adults use communication technology for partnering across relationship stages (formation, maintenance, and dissolution) and types (serious/casual), and proposes implications of usage in relationships. This study analyzed qualitative data from a five-week, prospective, coital diary method with related debriefing interviews (N = 70) of African American and Puerto Rican men and women aged 18 to 25 years in Hartford and Philadelphia. Cell phones, including calls, text messaging, and mobile Internet, were the most common forms of communication technology used for partnering goals. Participants reported using cell phones to pursue partnering goals across all relationship stages, including formation (meeting, screening, and getting to know new partners), maintaining existing relationships, and breaking up. Cell phone uses depended on the type of relationship (serious/casual) and the participants' intentions and desires. Results indicated that cell phones are an important element of communication among young adults in romantic and sexual relationships. Specific features of cell phone communication shape the process and context of partnering. Future research should explore emerging communication technologies and implications for psychosocial development, dating violence, and sexual behavior. 相似文献
115.
Michael Greenberg Paul Lioy Birnur Ozbas Nancy Mantell Sastry Isukapalli Michael Lahr Tayfur Altiok Joseph Bober Clifton Lacy Karen Lowrie Henry Mayer Jennifer Rovito 《Risk analysis》2013,33(11):1969-1986
We built three simulation models that can assist rail transit planners and operators to evaluate high and low probability rail‐centered hazard events that could lead to serious consequences for rail‐centered networks and their surrounding regions. Our key objective is to provide these models to users who, through planning with these models, can prevent events or more effectively react to them. The first of the three models is an industrial systems simulation tool that closely replicates rail passenger traffic flows between New York Penn Station and Trenton, New Jersey. Second, we built and used a line source plume model to trace chemical plumes released by a slow‐moving freight train that could impact rail passengers, as well as people in surrounding areas. Third, we crafted an economic simulation model that estimates the regional economic consequences of a variety of rail‐related hazard events through the year 2020. Each model can work independently of the others. However, used together they help provide a coherent story about what could happen and set the stage for planning that should make rail‐centered transport systems more resistant and resilient to hazard events. We highlight the limitations and opportunities presented by using these models individually or in sequence. 相似文献
116.
117.
Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation 下载免费PDF全文
Margaret Gamalo‐Siebers Jasmina Savic Cynthia Basu Xin Zhao Mathangi Gopalakrishnan Aijun Gao Guochen Song Simin Baygani Laura Thompson H. Amy Xia Karen Price Ram Tiwari Bradley P. Carlin 《Pharmaceutical statistics》2017,16(4):232-249
Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics. 相似文献
118.
This study examines the relationship between financial strain and depressive symptoms in later life, and potential psychosocial mediators of this relationship. Drawing on a sample of 214 low-income Latino older adults, we used structural equation modeling to test the direct effect of chronic financial strain on depressive symptomatology, and the indirect effects via social support, negative interaction, and coping styles. Findings indicated that financial strain increased the level of depressive symptoms among this sample. Avoidance and approach-related coping styles emerged as independent determinants of depressive symptoms albeit in opposite directions; higher levels of avoidance coping was associated with higher levels of depressive symptoms. Contrary to previous findings on the general population, findings from the current study indicate that social support and negative interaction were not directly associated with depressive symptoms. Financial strain mediated the effect of sociocultural (nativity status, years of U.S. residence) and social status factors (age, education) on depressive symptoms. This study highlights the differential impact of financial strain and coping styles on psychological well-being, and the potential psychosocial targets of interventions for older adults with chronic health care conditions. 相似文献
119.
Karen Lysaght 《National Identities》2013,15(1):59-71
The communal narrative of the Irish state defined the criteria for membership of the nation in opposition to the characteristics of the Irish gentry class, whether in their Protestantism, Anglicised lifestyles or external focus on Britain and its empire. The result ensured that while all Protestants engaged with the institutions of state, their inclusion in the nation proved much more difficult to negotiate, and for those with a gentry background, it would appear an impossibility. This article argues, in contrast, that the remnants of the Protestant gentry class successfully insert themselves into an alternative conception of the Irish nation that draws directly upon the longevity of their family association with specific localities in the Irish landscape. 相似文献
120.