Advantages of a wholly Bayesian approach to assessing efficacy in early drug development: a case study

This paper illustrates how the design and statistical analysis of the primary endpoint of a proof‐of‐concept study can be formulated within a Bayesian framework and is motivated by and illustrated with a Pfizer case study in chronic kidney disease. It is shown how decision criteria for success can be formulated, and how the study design can be assessed in relation to these, both using the traditional approach of probability of success conditional on the true treatment difference and also using Bayesian assurance and pre‐posterior probabilities. The case study illustrates how an informative prior on placebo response can have a dramatic effect in reducing sample size, saving time and resource, and we argue that in some cases, it can be considered unethical not to include relevant literature data in this way. Copyright © 2015 John Wiley & Sons, Ltd.     

The role,practice and training of unregulated birth workers in Australia: A mixed methods study

Background

In Australia, the provision of homebirth services by unregulated birthworkers (doulas, ex-registered midwives, traditional midwives and lay workers) has increased. Accessing a homebirth with a registered midwife via mainstream services is limited. Concern is growing that new legislation aimed at prohibiting unregulated birthworkers practice may result in homebirth going underground.

Military Occupations: Methodological Approaches and the Military–Academy Research Nexus

Military occupations are continually evolving in relation to the geopolitical changes of societies, their conflicts and conflict management strategies, and technological developments in military hardware and software. Military occupations studies undertaken by the academy have been key to informing government strategy towards the maintenance of functioning armed forces. Since the 1950s, such studies have prioritised ‘top‐down’ quantitative sociological methodologies. This paper reviews these studies and the role of the dominant Institutional/Occupational model. The paper then considers less influential ‘bottom up’ interpretive methodological studies of military occupations. It is suggested that the reliance on ‘top down’ modelling approaches has led to the paucity of studies describing the range and experiential detail of military occupations. The Military–Academy nexus, and the priorities of the discipline of sociology are suggested as reasons for this emphasis.     

Seeking Help from Clergy Among Black Caribbeans in the United States

This study examined use of clergy for serious personal problems within a representative sample of US black Caribbean adults from the National Survey of American Life. Logistic regression analysis was used and confirmed the importance of problem type, church involvement, and nativity as correlates of clergy use. Findings for black Caribbeans indicate similarities, as well as important departures from prior research on the correlates of clergy assistance among African Americans. These and other findings confirm the position of black Caribbeans as a distinctive ethnic subgroup within the general black population in the United States.     

Gender and the Limits to Diversity in the Contemporary British Army

This article considers equal opportunities and diversity management policies in the contemporary British Army for what they indicate, not only about policy frameworks for women's military participation, but also for what they tell us about the construction of ideas about gender and difference within that organization. The article sets out contextual information on women in the British Army and describes the research methodology on which this article is based. It looks at the evolution of equal opportunities policies and the more recent shift towards diversity management policies in the Army, focusing on their contributions towards female equity. The article examines the consequences of the shift towards the management of diversity, noting how embracing the ideas of diversity management is ultimately limited by the Army's construction of female difference. It concludes with a discussion of the issues of female and military specificity in relation to the management of diversity.     

Is Agency Skin Deep? Surface Attributes Influence Infants' Sensitivity to Goal‐Directed Action

Three studies investigated the role of surface attributes in infants' identification of agents, using a habituation paradigm designed to tap infants' interpretation of grasping as goal directed (Woodward, 1998). When they viewed a bare human hand grasping objects, 7‐ and 12‐month‐old infants focused on the relation between the hand and its goal. When the surface properties of the hand were obscured by a glove, however, neither 7‐ nor 12‐month‐old infants represented its actions as goal directed (Study 1). Next, infants were shown that the gloved hands were part of a person either prior to (Study 2) or during (Study 3) the habituation procedure. Infants who actively monitored the gloved person in Study 2 and older infants in Study 3 interpreted the gloved reaches as goal directed. Thus, varying the extent to which an entity is identifiable as a person impacts infants' interpretation of the entity as an agent.     

Risk Factors and Life Processes Associated with Teenage Pregnancy: Results of a Prospective Study From Birth to 20 Years

Data gathered over the course of a 20‐year longitudinal study of 533 New Zealand women were used to (a) describe the extent and timing of pregnancies within the cohort up to age 20, and (b) examine the extent to which the risk of an early pregnancy was related to a range of social background, family, individual, and peer relationship factors measured over the course of childhood and adolescence. Results showed that by age 20, nearly a quarter of the sample had been pregnant at least once, with the majority of first pregnancies occurring between the ages of 17 and 20 years. The profile of those at greatest risk of a teenage pregnancy (<20 years) was that of an early‐maturing girl with conduct problems who had been reared in a family environment characterized by parental instability and maternal role models of young single motherhood. As young adolescents, these girls were characterized by high rates of sexual risk‐taking and deviant peer involvement. Exposure to social and individual adversity during both childhood and adolescence made independent contributions to an individual's risk of an early pregnancy. These findings were most consistent with a life course developmental model of the etiology of teenage pregnancy. Implications for teenage pregnancy prevention are discussed.     

Reflections from the riot zone: The Fair Go Project and student engagement in a besieged community

This article describes and evaluates a pedagogical intervention aimed at improving student engagement in a very disadvantaged and low socio-economic status community in Australia. The intervention took place at a time of great community unrest and provides a contrast between wider public and media perceptions of poor communities and efforts at community renewal through education. A theoretical framework of student engagement developed in a research project into student engagement and students in poverty is introduced and then classroom changes that work within this framing are discussed. Finally, data showing results from the intervention are presented.     

The Goal Trumps the Means: Highlighting Goals is More Beneficial than Highlighting Means in Means‐End Training

Means‐end actions are an early‐emerging form of problem solving. These actions require initiating initial behaviors with a goal in mind. In this study, we explored the origins of 8‐month‐old infants’ means‐end action production using a cloth‐pulling training paradigm. We examined whether highlighting the goal (toy) or the means (cloth) was more valuable for learning to perform a well‐organized means‐end action. Infants were given the opportunity to both practice cloth‐pulling and view modeling of the action performed by an adult throughout the session. Infants saw either the same toy or the same cloth in successive trials, so that the goal or means were highlighted prior to modeling of the action. All infants improved throughout the session regardless of which aspect of the event was highlighted. Beyond this general improvement, repetition of goals supported more rapid learning and more sustained learning than did repetition of means. These findings provide novel evidence that, at the origins of means‐end action production, emphasizing the goal that structures an action facilitates the learning of new means‐end actions.