Evaluation of Inhaled Versus Deposited Dose Using the Exponential Dose‐Response Model for Inhalational Anthrax in Nonhuman Primate,Rabbit, and Guinea Pig

The application of the exponential model is extended by the inclusion of new nonhuman primate (NHP), rabbit, and guinea pig dose‐lethality data for inhalation anthrax. Because deposition is a critical step in the initiation of inhalation anthrax, inhaled doses may not provide the most accurate cross‐species comparison. For this reason, species‐specific deposition factors were derived to translate inhaled dose to deposited dose. Four NHP, three rabbit, and two guinea pig data sets were utilized. Results from species‐specific pooling analysis suggested all four NHP data sets could be pooled into a single NHP data set, which was also true for the rabbit and guinea pig data sets. The three species‐specific pooled data sets could not be combined into a single generic mammalian data set. For inhaled dose, NHPs were the most sensitive (relative lowest LD₅₀) species and rabbits the least. Improved inhaled LD₅₀s proposed for use in risk assessment are 50,600, 102,600, and 70,800 inhaled spores for NHP, rabbit, and guinea pig, respectively. Lung deposition factors were estimated for each species using published deposition data from Bacillus spore exposures, particle deposition studies, and computer modeling. Deposition was estimated at 22%, 9%, and 30% of the inhaled dose for NHP, rabbit, and guinea pig, respectively. When the inhaled dose was adjusted to reflect deposited dose, the rabbit animal model appears the most sensitive with the guinea pig the least sensitive species.     

Comic revisions? Motherhood and women’s comedy in contemporary Germany

Maternal stereotypes and the realities of mothering are prominent themes in Anke Engelke’s Ladykracher and Martina Hill’s Knallerfrauen, two of the most popular sketch shows in twenty-first-century Germany. This article relates their success to social anxieties about motherhood, which Engelke and Hill illuminate through the theme of their sketches as well as through their very use of comedy to do so. I begin by using close-readings of Ladykracher and Knallerfrauen to illuminate the political potential of the sketch form to challenge maternal myths and articulate taboo feelings such as maternal ambivalence. I then consider the innovation of these maternal sketches in view of traditional theories of comedy, which paradoxically draw their imagery from the realm of the maternal even though they discount real women and mothers as comic agents. I argue that the maternal sketches of Engelke and Hill are thus doubly subversive, challenging maternal taboos as well as the discursive and generic norms they sustain.     

Feeling disability: theories of affect and critical disability studies

This paper explores connections between affect studies and critical disability studies. Our interest in affect is sparked by the beginnings of a new research project that seeks to illuminate the lives, hopes and desires of young people with ‘life-limiting’ or ‘life-threatening’ impairments. Cultural responses to these young people are shaped by dominant discourses associated with lives lived well and long. Before commencing our empirical work with young people we use this paper to think through how we might conceptualise affect and disability. We present three themes; ontological invalidation in neoliberal-able times; affect aliens and crip killjoys; disability and resistant assemblages.     

Grillin’ with My Grandchild©: multigenerational programming for grandfathers and grandchildren

This article describes the Grillin’ with My Grandchild^© multigenerational relationship education program which is designed to encourage the enhancement and maintenance of a meaningful grandfather-grandchild relationship. During this multi-session program, grandfather and grandchild participants engage in several activities which include creating an electronic memory book as well as grilling and eating food together. They learn through facilitated discussion and by sharing personal experiences what it means to be a grandfather and a grandchild. Facilitated discussion about nutritional grilling practices and safe food grilling are implemented at each session. Grandfather-grandchild dyads interact with other familial dyads in their group and experience a sense of community and familiarity. Future research into the relational and psychological benefits of the program are suggested.     

Asymptotic theory for maximum likelihood estimates in reduced-rank multivariate generalized linear models

Reduced-rank regression is a dimensionality reduction method with many applications. The asymptotic theory for reduced rank estimators of parameter matrices in multivariate linear models has been studied extensively. In contrast, few theoretical results are available for reduced-rank multivariate generalized linear models. We develop M-estimation theory for concave criterion functions that are maximized over parameter spaces that are neither convex nor closed. These results are used to derive the consistency and asymptotic distribution of maximum likelihood estimators in reduced-rank multivariate generalized linear models, when the response and predictor vectors have a joint distribution. We illustrate our results in a real data classification problem with binary covariates.     

Trans Bodies and the Failure of Mirrors

This project applies and expands Gallagher’s (2005) theories concerning body image and body schema to the concept of gender in general and in particular how understanding gender through this lens can be used to aid transgender people in understanding their own gender. In addition, the paper discusses the effects of gender-incongruent mirroring for transgender and gender nonconforming persons’ ability to know their own feelings and its role in the development of shame. In furthering the understanding of gender and self-knowledge, the concepts of tacit knowledge and phantom limbs reveal how one comes to know gender as a fundamental aspect of the self.     

Communicating Actionable Risk for Terrorism and Other Hazards⋆

We propose a shift in emphasis when communicating to people when the objective is to motivate household disaster preparedness actions. This shift is to emphasize the communication of preparedness actions (what to do about risk) rather than risk itself. We have called this perspective “communicating actionable risk,” and it is grounded in diffusion of innovations and communication theories. A representative sample of households in the nation was analyzed using a path analytic framework. Preparedness information variables (including content, density, and observation), preparedness mediating variables (knowledge, perceived effectiveness, and milling), and preparedness actions taken were modeled. Clear results emerged that provide a strong basis for communicating actionable risk, and for the conclusion both that information observed (seeing preparedness actions that other have taken) and information received (receiving recommendations about what preparedness actions to take) play key, although different, roles in motivating preparedness actions among the people in our nation.