How Changes in Sending Countries Influenced Patterns of Interracial Families Through Intercountry Adoption

The racial characteristics of children adopted from abroad by American parents have fluctuated sharply over time in response to changing legislation and attitudes toward intercountry adoptions in the United States and the sending countries. This study investigates how the likelihood of parents adopting a White versus non-White child varies by the characteristics of the adopted child, the parents, and the household. Our analyses, using the 2008–2012 American Community Survey, show that parents consider the child's age, sex, and health; the presence of adopted and biologically related children in the household; and shifts in the availability of children across major sending countries.     

Bayesian adaptive patient enrollment restriction to identify a sensitive subpopulation using a continuous biomarker in a randomized phase 2 trial

With the development of molecular targeted drugs, predictive biomarkers have played an increasingly important role in identifying patients who are likely to receive clinically meaningful benefits from experimental drugs (i.e., sensitive subpopulation) even in early clinical trials. For continuous biomarkers, such as mRNA levels, it is challenging to determine cutoff value for the sensitive subpopulation, and widely accepted study designs and statistical approaches are not currently available. In this paper, we propose the Bayesian adaptive patient enrollment restriction (BAPER) approach to identify the sensitive subpopulation while restricting enrollment of patients from the insensitive subpopulation based on the results of interim analyses, in a randomized phase 2 trial with time‐to‐endpoint outcome and a single biomarker. Applying a four‐parameter change‐point model to the relationship between the biomarker and hazard ratio, we calculate the posterior distribution of the cutoff value that exhibits the target hazard ratio and use it for the restriction of the enrollment and the identification of the sensitive subpopulation. We also consider interim monitoring rules for termination because of futility or efficacy. Extensive simulations demonstrated that our proposed approach reduced the number of enrolled patients from the insensitive subpopulation, relative to an approach with no enrollment restriction, without reducing the likelihood of a correct decision for next trial (no‐go, go with entire population, or go with sensitive subpopulation) or correct identification of the sensitive subpopulation. Additionally, the four‐parameter change‐point model had a better performance over a wide range of simulation scenarios than a commonly used dichotomization approach. Copyright © 2016 John Wiley & Sons, Ltd.     

A Bayesian hierarchical mixture model for platelet-derived growth factor receptor phosphorylation to improve estimation of progression-free survival in prostate cancer

Summary.  Advances in understanding the biological underpinnings of many cancers have led increasingly to the use of molecularly targeted anticancer therapies. Because the platelet-derived growth factor receptor (PDGFR) has been implicated in the progression of prostate cancer bone metastases, it is of great interest to examine possible relationships between PDGFR inhibition and therapeutic outcomes. We analyse the association between change in activated PDGFR (phosphorylated PDGFR) and progression-free survival time based on large within-patient samples of cell-specific phosphorylated PDGFR values taken before and after treatment from each of 88 prostate cancer patients. To utilize these paired samples as covariate data in a regression model for progression-free survival time, and be cause the phosphorylated PDGFR distributions are bimodal, we first employ a Bayesian hierarchical mixture model to obtain a deconvolution of the pretreatment and post-treatment within-patient phosphorylated PDGFR distributions. We evaluate fits of the mixture model and a non-mixture model that ignores the bimodality by using a supnorm metric to compare the empirical distribution of each phosphorylated PDGFR data set with the corresponding fitted distribution under each model. Our results show that first using the mixture model to account for the bimodality of the within-patient phosphorylated PDGFR distributions, and then using the posterior within-patient component mean changes in phosphorylated PDGFR so obtained as covariates in the regression model for progression-free survival time, provides an improved estimation.     

Fertility preferences and subsequent childbearing in Africa and Asia: A synthesis of evidence from longitudinal studies in 28 populations

Survey data on fertility preferences have played a central but controversial role in fertility research and advocacy for family planning. We summarize evidence from longitudinal studies in 28 Asian and African populations on the relationship between preferences and subsequent childbearing. While we found no consistent association between women's desire to delay childbearing and subsequent fertility, the baseline desire of women to stop childbearing was a powerful predictor of subsequent fertility in all populations and increased in strength as overall contraceptive use in the study populations rose. Partners’ desire also exercised some influence but was of modest importance in most populations. However, the correspondence between desire to stop and behaviour was found to be far from perfect. Weak implementation of preferences by contraception is likely to be the major cause of this preference–behaviour discrepancy. Uncertainty and instability in preferences may also contribute to the discrepancy, particularly in sub-Saharan Africa.     

Multi-platform experiment to cross a boundary between laboratory and real situational studies: experimental discussion of cross-situational consistency of driving behaviors

We constructed an innovative experimental platform to study cross-situational consistency in driving behavior, conducted behavioral experiments, and reported the data obtained in the experiment. To discuss cross-situational consistency, we separated situations in which people use some systems to conduct tasks into three independent conceptual factors: environment, context, and system. We report the experimental results with the following systems: a laboratory system with a gaming controller and steering/pedal controllers and a real system, COMS an instrumented vehicle. The results are summarized as follows. 1) The individual behaviors in each system were stable, and consistency was retained. 2) The consistency of the behaviors was also confirmed when the participants drove using different interfaces in identical systems. 3) However, only slight correlation was observed across different systems in a specific situation where a strong high-order cognitive constraint (i.e., rapid driving) and a weak low-order cognitive constraint (driving with easy handling toward a straight-line course) were given.     

Desirable Difference: The Shadow of Racial Stereotypes in Creating Transracial Families through Transnational Adoption

The article analyzes how parents decide to adopt a child transnationally by detailing how the meaning of race is articulated in the formation of family. Drawing from my interviews with adoptive parents, I examine how they internalize ideas about different racial groups. For example, I investigate how what they have learned from the adoption agencies, their own perceptions of racial stereotypes, and their perceptions of the communities in which they reside influence their understanding of race. The article suggests that adoptive parents, when considering whether to adopt children from the U.S. or overseas, use a criteria dictated by racial stereotypes in understanding Asian Americans as the model minority, African-Americans as a deficient group, and Latinos occupying an intermediary position.     

Constructing Interracial Families Through Intercountry Adoption*

Objective. This article analyzes the role of race and ethnicity in constructing American families through intercountry adoption. We argue that such adoptions illustrate the fluidity and tenacity of specific racial boundaries in American families. Methods. Data are drawn from the U.S. 2000 Census—the first to contain information on children's adoptive status—to examine whether race of parents and adopted children match and whether racial matching varies by the characteristics of adoptive families and adopted children. Results. Our findings indicate that minority‐race parents are more likely than white parents to adopt a child of the same race as themselves, and that the odds of white parents, in particular, adopting a white versus nonwhite child from abroad are related to factors such as the age, sex, and health status of the child, as well the presence of other children in the household. Conclusion. Parents weigh a constellation of factors, including attributes of the adopted child and the children already in the household, when adopting a child of the same or different race from abroad.     

The Eugenic Transition of 1996 in Japan: from law to personal choice

The Eugenic Protection Law, which regulated sterilisation and abortion in Japan, had two aspects: one was to prevent the birth of people with specific diseases and impairments, and the other was to permit women to have an abortion for specified reasons. This law was criticised by both disabled people and feminists, and finally amended in 1996. Another eugenic practice related to both disabled people and women is prenatal screening. One prenatal diagnostic check, serum screening is a simple blood test carried out on the mother with little risk and no need for sophisticated techniques. It became very widespread in Japan around 1996 and was used with too little thought. As a result, it led to controversy. This paper discusses Japanese eugenics by reference to the Eugenic Protection Law and prenatal screening from the standpoint of both women and disabled people.