Dose intra-subject escalation to an event (DIETE): A new method for phase 1 dose-finding utilizing systematic intra-subject dose escalation with application to T-cell engagers

T-cell engagers are a class of oncology drugs which engage T-cells to initiate immune response against malignant cells. T-cell engagers have features that are unlike prior classes of oncology drugs (e.g., chemotherapies or targeted therapies), because (1) starting dose level often must be conservative due to immune-related side effects such as cytokine release syndrome (CRS); (2) dose level can usually be safely titrated higher as a result of subject's immune system adaptation after first exposure to lower dose; and (3) due to preventive management of CRS, these safety events rarely worsen to become dose limiting toxicities (DLTs). It is generally believed that for T-cell engagers the dose intensity of the starting dose and the peak dose intensity both correlate with improved efficacy. Existing dose finding methodologies are not designed to efficiently identify both the initial starting dose and peak dose intensity in a single trial. In this study, we propose a new trial design, dose intra-subject escalation to an event (DIETE) design, that can (1) estimate the maximum tolerated initial dose level (MTD1); and (2) incorporate systematic intra-subject dose-escalation to estimate the maximum tolerated dose level subsequent to adaptation induced by the initial dose level (MTD2) with a survival analysis approach. We compare our framework to similar methodologies and evaluate their key operating characteristics.     

Effectiveness of persuasive frames in advocacy videos

Using a three-condition, between-subjects experimental design (N = 152), this study investigates the persuasive effects of fear and humor in nonprofit advocacy-style videos. Findings indicate both fear and humor positively affect a behavioral willingness to change behaviors. Mediation analysis of the antecedent variables in the theory of planned behavior model also revealed significant indirect effects of each form of appeal through attitudes. Findings advance current conceptual and practical understanding of the persuasive power of nonprofit advocacy-style videos.     

Additive multi-effort contests

Theory and Decision - This article analyzes rent seeking with multiple additive efforts for each of two players. Impact on rent seeking occurs even when a player exerts only one effort. This...     

GRIND OR GAMBLE? AN EXPERIMENT ON EFFORT AND SPREAD SEEKING IN CONTESTS

We conduct a contest experiment to study if spread seeking and effort can be managed when participants can invest in increasing both the mean and the spread of an uncertain performance variable. Subjects are treated with different prize schemes and in accordance with theory, we observe higher investments in spread for the winner-take-all scheme. Both types of investments can be controlled with a three-level prize scheme. However, the control management is imperfect and behavior is characterized by inertia. We also explore the correlation between effort and spread across subjects and find that is robustly positive.     

AN EXPERIMENTAL STUDY OF KIN AND ETHNIC FAVORITISM

Ethnic and kinship ties have long been viewed as potential catalysts for favoritism, and hence corruption. In experiments conducted in three countries, we recruit siblings, coethnics and strangers and vary the relationship(s) between the players of a game to observe how kin and ethnic ties influence the willingness of two players to benefit one another at the expense of a third party. We see universal sibling favoritism, but ethnic favoritism, and favoritism toward other in-group members (friends) varies. We argue this may be driven in part by kinship institutions, since favoritism is more common in societies with denser kin networks. ( JEL D9, C9, D73, J12)     

Beyond Triangulation: Reconstructing Mandela’s Writing Life through Propulsive Facilitation at the Archive

Qualitative Sociology - Multimethod studies generally fall under what are referred to as “confirmatory” or “complementary” approaches. Yet in addition to these two...     

Substance use and decision‐making in adolescent best friendship dyads: The role of popularity

In adolescent best friendship dyads, we examined: (a) similarity in substance use and decision‐making; (b) associations between participants' decision‐making and their own and best friend's substance use, (c) the influence of relative popularity within the dyad on these associations. Participants (n = 172; 12–18 years) named their best friend, completed popularity ratings, and a substance use questionnaire. Computer tasks were administered to assess risk‐taking and immediate reward preferences. Reciprocated same‐sex best friendship dyads (n = 49) were distinguished on their popularity, and we controlled for age differences between dyads in the analyses. Best friends were similar in substance use and risk‐taking preferences. More popular friends' risk‐taking preferences were positively associated with alcohol use of less popular friends. These findings underscore best friendship similarity in risky behaviors, and the influence of popular friends.     

Superior Sporting Performance in Athletics: Determinants and Sustainability

The article aims to contribute to the understanding of competitive dynamics and specialization in international sport by analyzing superior sporting performance (SSP) in international athletics in the period from 1999 to 2018. By applying iterative Kolmogorov‐Smirnov tests to annual bests, the study examines national SSPs. Contrary to theoretical considerations, less specialized countries are more likely to achieve SSP. Technical entry barriers and macrosocial factors also appear to play a limited role. SSP seems not to disappear due to increased international competition. The United States and Russia are identified as “sporting super powers,” able to persistently dominate a number of disciplines. The case of Russia poses fundamental questions concerning market distortions in international sport resulting from doping. The results come with substantial policy implications.     

The Cognitive Domain of the Quality of Life of University Students: A Re-Analyses of an Instrument

This paper presents the re-analysis of a previouslypublished instrument, based on Bloom's taxonomy,developed to measure the cognitive domain of thequality of life of university students. The items inthis instrument were assessed using Guttman's SmallestSpace Analysis. The findings generally supportBloom's conceptualization, identifying 5 of 6dimensions in the taxonomy: Knowledge, Comprehension,Application, Analysis, and Evaluation. The findingsprovide support for the enduring utility of Bloom'staxonomy, and reinforce the ongoing need to testtheoretically informed instruments using sophisticatedstatistical techniques.     

Beyond GDP: Using Equivalent Incomes to Measure Well-Being in Europe

It has become widely accepted that focusing exclusively on income growth may lead to a too narrow-sighted measure of changes in well-being. People care about other dimensions of life, such as their health, employment, social interactions and personal safety. Moreover, an exclusive focus on income growth remains blind to the distribution of income and well-being in the society. We propose therefore a set of five principles for a richer measure of well-being. In particular, we advocate the use of a measure based on “equivalent incomes”, which satisfies these principles. We discuss and illustrate how this equivalent income approach can be implemented in Europe, using the ESS data for 2008 and 2010. We find that introducing inequality aversion and including other dimensions in the analysis leads to a remarkably different perspective on the growth of well-being in Europe.