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21.
A complete two-way cross-classification design is not practical in many settings. For example, in a toxicological study where 30 male rats are mated with 30 female rats and each mating outcome (successful or unsuccessful)is observed, time and resource considerations can make the use of the complete design prohibitively costly. Partially structured variations of this design are, therefore, of interest (e.g., the balanced disjoint rectangle design, the fully diagonal design, and the "S"-design). Methodology for analyzing binary data from such incomplete designs is illustrated with an example. This methodology, which is based on infinite population sampling arguments, allows the estimation of the mean response, among-row correlation coefficient, among-column correlation coefficient, and the within-cell correlation coefficient as well as their standard errors. 相似文献
22.
A case study in identifying targeted patients population in major depressive disorder by enhanced enrichment design 下载免费PDF全文
Peter Zhang Kevin Carroll Mary Hobart Carole Augustine Gary Koch 《Pharmaceutical statistics》2018,17(2):144-154
Despite advances in clinical trial design, failure rates near 80% in phase 2 and 50% in phase 3 have recently been reported. The challenges to successful drug development are particularly acute in central nervous system trials such as for pain, schizophrenia, mania, and depression because high‐placebo response rates lessen assay sensitivity, diminish estimated treatment effect sizes, and thereby decrease statistical power. This paper addresses the importance of rigorous patient selection in major depressive disorder trials through an enhanced enrichment paradigm. This approach led to a redefinition of an ongoing, blinded phase 3 trial algorithm for patient inclusion (1) to eliminate further randomization of transient placebo responders and (2) to exclude previously randomized transient responders from the primary analysis of the double blind phase of the trial. It is illustrated for a case study for the comparison between brexpiprazole + antidepressant therapy and placebo + antidepressant therapy. Analysis of the primary endpoint showed that efficacy of brexpiprazole versus placebo could not be established statistically if the original algorithm for identification of placebo responders was used, but the enhanced enrichment approach did statistically demonstrate efficacy. Additionally, the enhanced enrichment approach identified a target population with a clinically meaningful treatment effect. Through its successful identification of a target population, the innovative enhanced enrichment approach enabled the demonstration of a positive treatment effect in a very challenging area of depression research. 相似文献
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Ohne Zusammenfassung 相似文献
24.
Koch L 《International migration (Geneva, Switzerland)》1989,27(2):191-201
During the past 20 years, Italy has changed from being a country with well-established traditions of emigration to a country of destination. Italy had achieved 1 of the highest economic growth rates in the world. Conditions in Italy are favorable for hundreds of thousands of immigrants from developing countries. Most immigrants settle in large cities and in the South; most are in Italy illegally, performing jobs which Italians do not want. The Act n.943 of January 27, 1987, 1 of the most advanced and most liberal unilateral legal texts has 2 sections: 1) the 1st section establishes regulations governing the admission and residence of foreigners and conditions under which they may enter employment and 2) the 2nd section concerns the regularization of all situations involving the illegal presence of the hundreds of thousands of workers who arrived in Italy before 1987. During the 1st year of implementation, the Act proved to be ideologically enviable but unsuitable in practice. Specifically, Italian consulates in developing countries have received very few applications for permanent residence permits, while clandestine immigration is continuing. Also, only about 14% of clandestine immigrants who arrived before 1987 have regularized their situations. Insufficient information and excessive red tape in the regularization procedures contributed to these results. However, the fundamental cause of failure is economic: migrants know that regularization would keep them out of the labor market and be followed by loss of job and unemployment. Italians are uninterested in the role of immigrants as new members of society; the migrants, in turn, do everything possible not to draw attention to their presence and their diversity. Still, most Italians view immigrants with suspicion. To prepare for the future, account must be taken of possible fluctuations in the economic situation of expanding receiving countries and of the impact which these fluctuations may have on the degree of acceptance of immigrants. To solve these problems Italy must, 1) have a rational, realistic, and comprehensive approach to medium-term planning;2) use official development assistance to carry out labor-intensive projects in the partner country, to reduce the pressure to migrate; 3) base the planning of migration policy on the establishment of admission criteria for immigrants; 4) treat immigrants fairly and promote integration that respects their cultural identity; and 5) achieve international and multilateral coordination and consultation for migration policies. 相似文献
25.
More than one quarter of Americans now have tattoos. The proportion is even higher among younger adults. Tattoos express affiliation and identity. For some, tattoos also express religiosity. Very little research exists on religious tattoos. The purpose of this study is to profile religious tattoos among students at one Christian university in the southwestern United States. We analysed 752 photos of tattoos on campus. One in five photos depicted an overt religious image or text. Men were more likely than women to have a religious tattoo. In addition, the size, placement, and direction of religious tattoos differed by gender. Men’s religious tattoos were larger in size and in more prominent places on their bodies. Women’s religious tattoos were smaller and in more easily concealed locations. We conclude with a discussion of the practical and theoretical implications of our findings. 相似文献
26.
This paper offers a critical feminist analysis of the biomedical conceptualization of women's sexual desire. The five major features of the biomedical model of female sexual desire examined and critiqued are: 1) use of the male model as the standard, 2) use of a linear model of sexual response, 3) biological reductionism, 4) depoliticalization, and 5) medicalization of variation. A "New View", an alternative to the biomedical model, is offered for reconceptualizing women's sexual problems. This analysis concludes with recommendations for feminist-based biopsychosocial research. 相似文献
27.
Frank Ritz Cornelia Kleindienst Julia Koch Jonas Brüngger 《Gruppendynamik und Organisationsberatung》2016,47(2):151-158
This article examines how resilience of organizations can be enhanced by promoting their capability for adaptation. In a first step, the current understanding of the conceptualization of organizational resilience is compared to the resilience of individuals and teams. In a second step, the article also aims to illustrate the relationship between organizational resilience and organizational culture. Based on this, the applied research and development project “TeamSafe” in collaboration with a nuclear power plant is described as an example of a resilience-oriented training concept and a method for coping with unknown situations. In this project a multi-methodological approach (observational methods, video analysis and workshops) was chosen in order to identify relevant competencies and combine them with scientific findings. By involving simulator instructors and operating teams during the development process of the training concept, crucial action knowledge of operating teams in a nuclear power plant was gained by observations in the simulator and shared between different teams. This enabled the resilience-oriented development of the organization’s culture. 相似文献
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29.
Jill M. Wood Patricia Barthalow Koch Phyllis Kernoff Mansfield 《Journal of sex research》2013,50(3):236-244
This article offers a critical feminist analysis of the biomédical conceptualization of women's sexual desire. The five major features of the biomedical model of female sexual desire examined and critiqued are (a) use of the male model as the standard, (b) use of a linear model of sexual response, (c) biological reductionism, (d) depoliticalization, and (e) medicalization of variation. A “New View,” an alternative to the biomédical model, is offered for reconceptualizing women's sexual problems. This analysis concludes with recommendations for feminist‐based biopsychosocial research. 相似文献
30.
Bivariate time series models are built that describe the empirical relationships between industrial production and components of the Composite Index of Leading Indicators (CLI). This reveals the indicators' average lead times at all points of the business cycle, the forms of the distributed lags involved, and their ability to explain later movements in economic activity. The relationship between industrial production and the CLI is also examined and used to test the contribution of the CLI toward improving time series model forecasts of the 1980 and 1981 recessions. 相似文献