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91.
92.
In this paper, we describe a method of comparing agreement between two diagnostic contingency tables after adjustment to more clinically relevant marginal distributions using the iterative proportional fitting algorithm. When the categories of a contingency table represent mild, moderate, and severe outcomes, the majority of patients often are in the mild category. Because it is often of more interest to evaluate agreement when patients are uniformly distributed among categories, we present the primary results of two clinical trials with adjustment to this structure. We also describe the relationship between the sponsor's pre‐specified agreement measure for the observed contingency table and kappa for the adjusted table; and by either criterion, we then show that the agreement of the new diagnostic tool with the standard diagnostic tool is comparably non‐inferior to the agreement of the standard diagnostic tool with itself. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
93.
Janice Koch 《经理人》2006,(4):74-75
客户回报率是衡量公司通过客户创造价值能力的惟一现有指标由于越来越多的企业争夺有限的客户群,精明的企业逐渐将关注点转向客户——如何维系及培养高价值的客户。近来,客户管理专家唐·佩勃斯与玛莎·罗杰斯提出了一个新指标:客 相似文献
94.
Phyllis M. Koch M.A. 《Child and Adolescent Social Work Journal》1987,4(3-4):89-96
This paper discusses work with a parent in a foster care situation. A case example is used to demonstrate the value of a model of a parentchild relationship for therapeutic work with seemingly unmotivated clients such as parents whose child is in foster care. 相似文献
95.
96.
Anika Großhennig Nele Henrike Thomas Werner Brannath Armin Koch 《Pharmaceutical statistics》2023,22(5):836-845
Formal proof of efficacy of a drug requires that in a prospective experiment, superiority over placebo, or either superiority or at least non-inferiority to an established standard, is demonstrated. Traditionally one primary endpoint is specified, but various diseases exist where treatment success needs to be based on the assessment of two primary endpoints. With co-primary endpoints, both need to be “significant” as a prerequisite to claim study success. Here, no adjustment of the study-wise type-1-error is needed, but sample size is often increased to maintain the pre-defined power. Studies that use an at-least-one concept have been proposed where study success is claimed if superiority for at least one of the endpoints is demonstrated. This is sometimes also called the dual primary endpoint concept, and an appropriate adjustment of the study-wise type-1-error is required. This concept is not covered in the European Guideline on multiplicity because study success can be claimed if one endpoint shows significant superiority, despite a possible deterioration in the other. In line with Röhmel's strategy, we discuss an alternative approach including non-inferiority hypotheses testing that avoids obvious contradictions to proper decision-making. This approach leads back to the co-primary endpoint assessment, and has the advantage that minimum requirements for endpoints can be modeled flexibly for several practical needs. Our simulations show that, if planning assumptions are correct, the proposed additional requirements improve interpretation with only a limited impact on power, that is, on sample size. 相似文献
97.
Value creation for consumers, as the conditio sine qua non for value capture, is at the heart of demand-side strategy research and is a core element of almost any business model. In this paper, we discuss the unique ideas that demand-side strategy and business model research jointly contribute to the strategy literature, and we elaborate on the potential for cross-fertilization between both areas of study. We argue that both the demand-side perspective and the business model concept could jointly promote a better understanding of strategy-making by mutually relying on the distinctive insights from each stream; specifically, while research on demand-side strategy can help business model scholars gain a more robust and granular understanding of effective value propositions, business models can serve as a “bridging concept” that links the shared ideas of both areas of study to resource-based streams of strategy research. 相似文献
98.
Douglas Knutson Julie M. Koch Jenilee Sneed Anthony Lee 《Journal of LGBT Issues in Counseling》2018,12(1):32-50
To better understand psychological experiences of drag queens, the authors conducted interviews with 12 cisgender, gay male drag queens from a midsouth state. Participants were age 22 to 54 years (M = 34) and reported participating in drag for 2 to 33 years (M = 13). The authors used consensual qualitative analysis to identify five main themes: motivation, effects, protective factors, stressors, and involvement. Results indicate that participants in drag may benefit from social support, a creative outlet, and empowerment. Participants also reported experiences of discrimination, performance anxiety, and loss of friendships. We discuss implications for counseling lesbian, gay, bisexual, and transgender people who may perform in drag. 相似文献
99.
Coping with missing data in phase III pivotal registration trials: Tolvaptan in subjects with kidney disease,a case study 下载免费PDF全文
Missing data cause challenging issues, particularly in phase III registration trials, as highlighted by the European Medicines Agency (EMA) and the US National Research Council. We explore, as a case study, how the issues from missing data were tackled in a double‐blind phase III trial in subjects with autosomal dominant polycystic kidney disease. A total of 1445 subjects were randomized in a 2:1 ratio to receive active treatment (tolvaptan), or placebo. The primary outcome, the rate of change in total kidney volume, favored tolvaptan (P < .0001). The key secondary efficacy endpoints of clinical progression of disease and rate of decline in kidney function also favored tolvaptan. However, as highlighted by Food and Drug Administration and EMA, the interpretation of results was hampered by a high number of unevenly distributed dropouts, particularly early dropouts. In this paper, we outline the analyses undertaken to address the issue of missing data thoroughly. “Tipping point analyses” were performed to explore how extreme and detrimental outcomes among subjects with missing data must be to overturn the positive treatment effect attained in those subjects who had complete data. Nonparametric rank‐based analyses were also performed accounting for missing data. In conclusion, straightforward and transparent analyses directly taking into account missing data convincingly support the robustness of the preplanned analyses on the primary and secondary endpoints. Tolvaptan was confirmed to be effective in slowing total kidney volume growth, which is considered an efficacy endpoint by EMA, and in lessening the decline in renal function in patients with autosomal dominant polycystic kidney disease. 相似文献
100.
Dr. Kai-Christian Koch Dipl.-Psych. Dipl.-Päd. Lehramt P 《Gruppendynamik und Organisationsberatung》2014,45(1):57-71
Teacher surveys indicate continued intense discipline problems in elementary school classes. What can you do about it? As the teacher behavior has a strong relationship with active cooperation and misbehavior of students, a skillful group or classroom management of the teacher for an undisturbed instruction is important. However evidence suggests that some in the research literature as particularly relevant documented behaviors hardly appear in teachers’ subjective theories of reducing discipline problems. It is therefore presumed that the level of awareness regarding these insights is low in elementary schools and that it is difficult for teachers to recognize their extraordinary relevance solely by teaching practice. The present study tests this hypothesis on a sample of 101 elementary school teachers. The potentially far-reaching implications of the results are discussed. 相似文献