A review of statistical methods in imaging genetics

With the rapid growth of modern technology, many biomedical studies are being conducted to collect massive datasets with volumes of multi‐modality imaging, genetic, neurocognitive and clinical information from increasingly large cohorts. Simultaneously extracting and integrating rich and diverse heterogeneous information in neuroimaging and/or genomics from these big datasets could transform our understanding of how genetic variants impact brain structure and function, cognitive function and brain‐related disease risk across the lifespan. Such understanding is critical for diagnosis, prevention and treatment of numerous complex brain‐related disorders (e.g., schizophrenia and Alzheimer's disease). However, the development of analytical methods for the joint analysis of both high‐dimensional imaging phenotypes and high‐dimensional genetic data, a big data squared (BD²) problem, presents major computational and theoretical challenges for existing analytical methods. Besides the high‐dimensional nature of BD², various neuroimaging measures often exhibit strong spatial smoothness and dependence and genetic markers may have a natural dependence structure arising from linkage disequilibrium. We review some recent developments of various statistical techniques for imaging genetics, including massive univariate and voxel‐wise approaches, reduced rank regression, mixture models and group sparse multi‐task regression. By doing so, we hope that this review may encourage others in the statistical community to enter into this new and exciting field of research. The Canadian Journal of Statistics 47: 108–131; 2019 © 2019 Statistical Society of Canada     

Designing and implementing an evaluation of a national work support program

Welfare reforms in the 1990s have shifted governments around the world towards financial assistance conditional on work. While large-scale rigorous research on welfare-to-work programs has demonstrated effectiveness towards employment in other countries, no such micro-level evaluation of a policy has ever been conducted in Singapore. This article describes the process of developing a large experimental evaluation of the Work Support Program, which the Ministry of Community Development, Youth and Sports started in 2006. The lessons learned from planning and implementing the research can be helpful to future researchers in negotiating long-term rigorous evaluations in an environment where collaborators lack sufficient research knowledge. Insights include ways to focus on the essentials, find alternative experimental designs, collaborate effectively, and adapt instruments across cultures.     

论实践作为人之存在方式的历史性基础

马克思主义所实现的哲学变革,从根本上说是把实践视为人的存在方式,并从人的实践活动去看待和解释人与世界的全部关系。而理解实践作为人的存在方式必须要有一个历史唯物主义的基础。社会历史性是实践的真正本性,历史是展开实践过程的基础和内在机制。     

辽宁国有企业文化创新的战略意义及其影响

国有企业改革对于辽宁这样一个国有经济发展最早、比重最大的省份来说,是一个循序渐进的过程。在经过“九五”时期的改革与脱困、“十五”时期的调整和改造之后,“十一五”时期将进入巩固与提高的全面振兴阶段。目前,辽宁大多数国有企业已经完成股份制改造,体制机制创新初见成效。但是,国有企业建立现代企业制度既需要体制机制创新,也需要与之相适应的企业文化创新。探讨辽宁国有企业文化创新的战略意义及其影响,至关重要。     

乳品工程专业创新型“3+1”人才培养模式的优化研究与实践

为研究获得东北农业大学乳品工程专业创新型"3+1"人才培养模式,本文通过对现行的乳品工程专业"3+1"培养模式存在的问题进行分析,特别是通过对培养模式"3"及"1"中存在问题进行了调研与分析后,又对课程设置进行重新的调整与安排,制定出了合理、科学、可行的"3+1"人才培养方案,完善了实训基地的管理制度和条例,建立了实训基地的基本条件和要求;最终将优化的乳品工程专业创新型"3+1"人才培养方案应用到本科教学实践中,使培养的学生具有较强的创新和实践动手能力,成为乳品工程领域的高级技术人才。     

20世纪80年代以来中国大陆十六国北朝思想史研究的回顾与展望(上)

20世纪80年代以来,十六国、北朝思想史研究领域中产生了一些令人瞩目的研究成果,同时也存在研究力量薄弱、研究方法缺乏多样性以及有学术突破的成果不多的客观现实.十六国北朝思想史研究的深入和新成就的取得,有待于学界的充分重视,有待于更多的资料被发掘和利用,有待于研究理论、观念和方法的创新.     

山西票号高效执行力的动力机制

本文提出高效执行力是企业最重要的竞争力之一的观点,文章以山西票号的案例,评介了其经营战略与制度的执行情况,分析了其高效执行力来自动力机制与训育机制,认为动力机制是两全分离制、人身股制、薪酬福利社保制、宗法与担保制,其训育机制是学徒制,这些历史经验对当代企业管理有重要的现实意义。     

敏感性问题随机化回答模型的改进

敏感性问题随机化回答模型的改进孔圣元孟生旺ＡＢＳＴＲＡＣＴＴｈｅｐａｐｅｒｆｉｒｓｔｅｖａｌｕａｔｅｓｈｏｒｔａｇｅｏｆｅｘｉｓｔｉｎｇｒａｎｄｏｍｒｅｓｐｏｎｓｅｍｏｄｅｌｏｆｓｅｎｓｉ－ｔｉｖｅｐｒｏｂｌｅｍｓ,ａｎｄｔｈｅｎｓｅｔｕｐａｎｅｗｒ...     

打破增长型经济复苏的幻觉

1997年亚洲金融危机暴发后,我国实施了以扩大内需为核心的经济刺激政策。在此后走出危机的五年中,尽管在政策作用下经济增长得以持续,但是就业增长与民生改善并不明显。这对于正处于复苏拐点的中国经济来说具有较强的启发意义,即应打破增长型经济复苏的幻觉,在经济颓势得以扭转之后必须考虑短期政策与长期战略的结合。为此,应考虑从促进中小企业发展与扶助个人创业,推进经济布局与结构优化,从城乡统筹发展视角实施土地、教育、社会保障等制度变革等方面对现行政策予以完善。     

生物医学模式的战略升级与精神健康社会工作的战略地位

生物医学模式向生物—心理—社会医学模式水平转型过渡已成世界医学发展趋势,实质是生物医学范围由单一生理疾病扩大到精神心理障碍、行为障碍与社会问题,精髓是生物医学模式范围横向或水平性扩展。同时,生物医学模式向生理—心理—社会—精神医学模式战略升级,实质是生物医学模式由平面性生理疾病升级为立体性生理—心理—社会—精神医学模式,精髓是生物医学模式纵向或垂直性结构分化。中国精神心理健康已成重大社会问题,精神健康社会工作在精神疾病防治体系中处于战略地位,扮演举足轻重角色,发挥重要作用。文章从精神心理健康角度,简要论述精神健康社会工作的紧迫性、必要性和重要性。