Evaluating basic research strategies

A model has been developed to describe the pharmaceutical research and drug innovation process. The model originally served to show the range of results that could arise from research in the field of infectious disease chemotherapy over a sustained period of time. The main goal of the model was to illuminate the risk/reward/time tradeoff faced by management in selecting a particular research strategy. The results obtained with this model were one of several considerations influencing the research strategy decision of CIBA-GEIGY in 1976 to adapt and strengthen its research effort in infectious disease chemotherapy.This model has so far been applied only for the comparative evaluation of infectious disease chemotherapy research strategies. However, there is no conceptual reason why it should be limited to this field of drug research or indeed to pharmaceutical research at all. This type of analysis should be applicable wherever clear, product-oriented research goals can be identified and defined, where some reasonable financial reward can be attached to achieving these goals, and where an assessment—albeit subjective—can be made of the likelihood of achieving these goals.     

Suicide Attempts by Adolescent Latinas: An Exploratory Study of Individual and Family Correlates

Epidemiological data show high rates of suicide attempts among adolescent Latinas. Few studies have addressed the psychosocial, cultural and family correlates of suicide attempts among this age group of a rapidly growing population. The authors studied 31 adolescent Hispanic females who were receiving mental health services; 14 girls had attempted suicide in the previous five years and 17 had never attempted suicide. The two groups of girls did not differ significantly with respect to demographic profiles, levels of depression, family type, acculturation, or self-esteem. However, as hypothesized, the mutuality between girls and their mothers was lower among suicide attempters. Maladaptive coping skills of withdrawal and wishful thinking were more commonly used by attempters, and non-attempters used emotional regulation and problem-solving more frequently. Findings are discussed within the context of the empirical and theoretical literature and implications for practice are considered.     

Do gender differences in preferences for competition matter for occupational expectations?

Occupational segregation by gender is prevalent and can explain some of the gender wage gap. I empirically investigate a possible explanation for this segregation: the gender difference in preferences for competition, which in recent experimental studies has been found to affect economic outcomes. My findings suggest that women’s greater distaste for competition decreases educational achievement. It can also explain part of the gender segregation in occupational fields. Specifically, accounting for distaste for competition seems to reduce gender segregation in the fields of Law, Business & Management, Health, and Education.     

The Continued Importance of Quality Parent–Adolescent Relationships During Late Adolescence

The quality of adolescents' relationships with residential parents has been found to predict many different health and behavioral youth outcomes; strong associations have also been found between these outcomes and family processes, and between relationship quality and family processes. Data from Rounds 1–5 of the National Longitudinal Survey of Youth, 1997 were used to examine hypotheses about the influence of the parent–adolescent relationship on subsequent adolescent mental well‐being and delinquency, as mediated by family processes. Using structural equation modeling, we found that the influence of a positive residential parent–adolescent relationship on better mental well‐being and fewer delinquency was entirely mediated by family routines, parental monitoring, and parental supportiveness, net of sociodemographic controls.     

Convergence in Foreigners’ Rights and Citizenship Policies? A Look at Japan

Citizenship laws and immigrant rights in rich, democratic countries are widely understood to be converging. Since most accounts of convergence are based on Western examples, Japan is an important test case. I distinguish three theoretical accounts of convergence: global‐institutionalist, liberal‐democratic, and problem‐solving perspectives. I then examine trends in foreigners’ rights in Japan since World War II in three domains: entrance, rights of residents, and citizenship. I find that convergence is occurring in the expansion of rights, partially in access to the territory, but not in formal citizenship. While the liberal‐democratic perspective fails to account for trends, a combination of global‐institutionalist and problem‐solving accounts provides the most powerful analytic insight into convergence processes.     

Factors Associated With Substance Use Disorders Among Traumatized Homeless Youth

This study aimed to identify homeless youths’ lifestyle and trauma-related risk factors as well as protective factors associated with alcohol use disorder or no disorder and drug use disorder or no disorder. Youth receiving homeless services in Denver (n = 201), Austin (n = 200), and Los Angeles (n = 200; N = 601) completed quantitative interviews assessing demographic information, alcohol and drug use, homeless lifestyle risk factors, trauma-related risk factors, and protective factors. Findings showed differences in trauma-related risk factors between alcohol and drug use disorders, but not homeless lifestyle risks. Protective factors predicted substance use disorders beyond risk factors. Understanding trauma-related risk and protective factors associated with substance use disorders could improve interventions.     

He Said What? Guided Cognitive Reframing About the Co‐Resident Father/Stepfather–Adolescent Relationship

We studied young adolescents' seeking out support to understand conflict with their co‐resident fathers/stepfathers, and the cognitive and affective implications of such support‐seeking, phenomena we call guided cognitive reframing. Our sample included 392 adolescents (M_age = 12.5, 52.3% female) who were either of Mexican or European ancestry and lived with their biological mothers and either a stepfather or a biological father. More frequent reframing was associated with more adaptive cognitive explanations for father/stepfather behavior. Cognitions explained the link between seeking out and feelings about the father/stepfather and self. Feelings about the self were more strongly linked to depressive symptoms than cognitions. We discuss the implications for future research on social support, coping, guided cognitive reframing, and father–child relationships.