Comparing two measures of creatinine clearance: an application of errors-in-variables and bootstrap techniques

Two indices of creatinine clearance (an index of kidney function) are compared on a group of cancer patients who underwent chemotherapy with a potentially nephrotoxic drug. The standard index, measured creatinine clearance MCC, is cumbersome to use, whereas the more convenient alternative, estimated creatinine clearance ECC, has not yet been conclusively evaluated on cancer patients. We conclude that under certain clinical conditions ECC and MCC are identically calibrated for males, but not for females, and we obtain estimated true and false positive rates for assessing the use of ECC instead of MCC as a diagnostic tool. We use a model that is formally equivalent to an errors-in-variables model with (unbalanced) repeated observations and correlated measurement errors. The bootstrap is used to obtain standard errors and confidence limits.     

Collinearity, Bias, and Effect Size: Modeling “the” Effect of Track on Achievement

The estimated effect of any factor can be highly dependent on both the model and the data used for the analyses. This article presents an example of the estimated effect of one factor in two different data sets under three different forms of the standard linear model using the effect of track placement on achievement as an example. Some relative advantages and disadvantages of each model are considered. The analyses demonstrate that, given collinearity among the predictor variables, a model with a poorer statistical fit may be useful for some interpretive purposes.     

A pragmatic approach to experimental design in industry

The importance of statistically designed experiments in industry has been well recognized. However, the use of 'design of experiments' is still not pervasive, owing in part to the inefficient learning process experienced by many non-statisticians. In this paper, the nature of design of experiments, in contrast to the usual statistical process control techniques, is discussed. It is then pointed out that for design of experiments to be appreciated and applied, appropriate approaches should be taken in training, learning and application. Perspectives based on the concepts of objective setting and design under constraints can be used to facilitate the experimenters' formulation of plans for collection, analysis and interpretation of empirical information. A review is made of the expanding role of design of experiments in the past several decades, with comparisons made of the various formats and contexts of experimental design applications, such as Taguchi methods and Six Sigma. The trend of development shows that, from the realm of scientific research to business improvement, the competitive advantage offered by design of experiments is being increasingly felt.     

Nonparametric regression estimates with censored data based on block thresholding method

Here we consider wavelet-based identification and estimation of a censored nonparametric regression model via block thresholding methods and investigate their asymptotic convergence rates. We show that these estimators, based on block thresholding of empirical wavelet coefficients, achieve optimal convergence rates over a large range of Besov function classes, and in particular enjoy those rates without the extraneous logarithmic penalties that are usually suffered by term-by-term thresholding methods. This work is extension of results in Li et al. (2008). The performance of proposed estimator is investigated by a numerical study.     

On the recoding of continuous and bounded indexes to a binomial form: an application to quality-of-life scores

The statistical analysis of patient-reported outcomes (PROs) as endpoints has shown to be of great practical relevance. The resulting scores or indexes from the questionnaires used to measure PROs could be treated as continuous or ordinal. The goal of this study is to propose and evaluate a recoding process of the scores, so that they can be treated as binomial outcomes and, therefore, analyzed using logistic regression with random effects. The general methodology of recoding is based on the observable values of the scores. In order to obtain an optimal recoding, the evaluation of the recoding method is tested for different values of the parameters of the binomial distribution and different probability distributions of the random effects. We illustrate, evaluate and validate the proposed method of recoding with the Short Form-36 (SF-36) Survey and real data. The optimal recoding approach is very useful and flexible. Moreover, it has a natural interpretation, not only for ordinal scores, but also for questionnaires with many dimensions and different profiles, where a common method of analysis is desired, such as the SF-36.     

Discrete Multicolour Random Mosaics with an Application to Network Extraction

We introduce a class of random fields that can be understood as discrete versions of multicolour polygonal fields built on regular linear tessellations. We focus first on a subclass of consistent polygonal fields, for which we show Markovianity and solvability by means of a dynamic representation. This representation is used to design new sampling techniques for Gibbsian modifications of such fields, a class which covers lattice‐based random fields. A flux‐based modification is applied to the extraction of the field tracks network from a Synthetic Aperture Radar image of a rural area.     

Iterative bias reduction: a comparative study

Multivariate nonparametric smoothers, such as kernel based smoothers and thin plate splines smoothers, are adversely impacted by the sparseness of data in high dimension, also known as the curse of dimensionality. Adaptive smoothers, that can exploit the underlying smoothness of the regression function, may partially mitigate this effect. This paper presents a comparative simulation study of a novel adaptive smoother (IBR) with competing multivariate smoothers available as package or function within the R language and environment for statistical computing. Comparison between the methods are made on simulated datasets of moderate size, from 50 to 200 observations, with two, five or 10 potential explanatory variables, and on a real dataset. The results show that the good asymptotic properties of IBR are complemented by a very good behavior on moderate sized datasets, results which are similar to those obtained with Duchon low rank splines.     

Progressive type II censored order statistics from exponential distributions

In the model of progressive type II censoring, point and interval estimation as well as relations for single and product moments are considered. Based on two-parameter exponential distributions, maximum likelihood estimators (MLEs), uniformly minimum variance unbiased estimators (UMVUEs) and best linear unbiased estimators (BLUEs) are derived for both location and scale parameters. Some properties of these estimators are shown. Moreover, results for single and product moments of progressive type II censored order statistics are presented to obtain recurrence relations from exponential and truncated exponential distributions. These relations may then be used to compute all the means, variances and covariances of progressive type II censored order statistics based on exponential distributions for arbitrary censoring schemes. The presented recurrence relations simplify those given by Aggarwala and Balakrishnan (1996)     

INFLUENCE FUNCTIONS IN FUNCTIONAL MEASUREMENT ERROR MODELS WITH REPLICATED DATA

We consider the construction and properties of influence functions in the context of functional measurement error models with replicated data. In these models estimates of the parameters can be affected both by the individual observations and the means of replicated observations. We show that influence function of the means of replicates on the estimate of regression coefficients can be only derived under the assumption that the variances of the errors are known, while one for the individual observations can be only derived simultaneously with their influence function on the estimators of the variances of the errors.