Survival Analysis For A Sequenced Clinical Trial With Covariates

In this paper we discuss the survival analysis for a clinical trial in which treatment categories and general prognostic data are realised at different stages during a patient's survival time. In the light of possible strategies for the parsimonious modelling of such data, a corresponding sequence of illustrative analyses is presented. Detailed results are given for a weighted least squares analysis and these generally agree with those obtained by maximum likelihood.     

The older lesbian

This research uncovers a pattern of support and the existence of a relationship network that runs strongly counter to the stereotyped view that lesbians in later life find themselves friendless and without support. The hypothesis that the older lesbian has developed friendship networks to replace missing or weak kin ties is substantiated. The findings are based on 20 in-depth, structured interviews with lesbians whose ages range from 50 to 73.     

Familial spinal shape

It has been proposed that there is a familial relationship in the shape of the spine. This paper describes a pilot study investigating familial shape in the sagittal plane (side view), using three data sets of normal Leeds schoolchildren. The study is exploratory in nature, because only small samples were available. Data acquisition was by means of the Quantec system, which obtains surface shape measurements and extracts a line representing the spinal curve. The coordinates of the spine line in the sagittal plane are then used to investigate familial correlations of spinal shape. The spine lines first undergo some preprocessing, including Procrustes rotations to remove location, rotation and size effects. Smoothed principal component analysis of the curves provides suitable shape variables, and familial correlations between curves are then investigated. The covariates of sex and height are also investigated in the analysis. It does appear that there could be some evidence for familial correlations in sagittal spinal shape, although a further large-scale study is required. Finally, a discussion of the approach and other alternatives is considered.     

Treatment of psychogenic seizures in adolescents

This article will review the problem of psychogenic seizures in adolescents and the impact of family therapy and individual therapy on treatment. Why particular individuals are prone to psychogenic seizures, the relationship between psychogenic seizures and family dynamics, and unresolved individual issues will be covered. The article will address a selected case, with a specific clinical paradigm for treatment.     

Fast Mapping but Poor Retention by 24‐Month‐Old Infants

Four experiments explored the processes that bridge between referent selection and word learning. Twenty‐four‐month‐old infants were presented with several novel names during a referent selection task that included both familiar and novel objects and tested for retention after a 5‐min delay. The 5‐min delay ensured that word learning was based on retrieval from long‐term memory. Moreover, the relative familiarity of objects used during the retention test was explicitly controlled. Across experiments, infants were excellent at referent selection, but very poor at retention. Although the highly controlled retention test was clearly challenging, infants were able to demonstrate retention of the first 4 novel names presented in the session when referent selection was augmented with ostensive naming. These results suggest that fast mapping is robust for reference selection but might be more transient than previously reported for lexical retention. The relations between reference selection and retention are discussed in terms of competitive processes on 2 timescales: competition among objects on individual referent selection trials and competition among multiple novel name–object mappings made across an experimental session.     

INFLUENCE OF AN INVITATION TO ANSWER BY TELEPHONE ON RESPONSE TO CENSUS QUESTIONNAIRES

An experimental test was made of whether completion rates fora census questionnaire could be improved by offering the optionof calling a toll-free number and providing the requested informationto an interviewer as an alternative to mailing it back. Conductedon a national probability sample of house holds, five treatmentpanels were created to examine the effect of delivering, indifferent ways, the invitation to respond by telephone or mail.Offering such invitations did not improve completion rates exceptwhen included with a follow-up letter that did not also includea replacement questionnaire.