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71.
Martin J. Wolfsegger Alexander Bauer Detlew Labes Helmut Schütz Richardus Vonk Benjamin Lang Stephan Lehr Thomas F. Jaki Werner Engl Michael D. Hale 《Pharmaceutical statistics》2021,20(2):272-281
For the clinical development of a new drug, the determination of dose-proportionality is an essential part of the pharmacokinetic evaluations, which may provide early indications of non-linear pharmacokinetics and may help to identify sub-populations with divergent clearances. Prior to making any conclusions regarding dose-proportionality, the goodness-of-fit of the model must be assessed to evaluate the model performance. We propose the use of simulation-based visual predictive checks to improve the validity of dose-proportionality conclusions for complex designs. We provide an illustrative example and include a table to facilitate review by regulatory authorities. 相似文献
72.
Laurie Drabble Sue Thomas Lisa O’Connor Sarah C. M. Roberts 《Journal of social work practice in the addictions》2014,14(2):191-206
This article describes U.S. state policies related to alcohol use during pregnancy, using data from the National Institute on Alcohol Abuse and Alcoholism Alcohol Policy Information System. Specifically, this study examines trends in policies enacted by states over time and types of policies enacted across states in the United States, with a focus on whether laws were supportive or punitive toward women. Findings revealed substantial variability in characteristics of policies (19 primarily supportive, 12 primarily punitive, 12 with a mixed approach, and 8 with no policies). Findings underscore the need to examine possible consequences of policies, especially of punitive policies and “mixed” approaches. 相似文献
73.
74.
Nancy Eisenberg Rg Haugen Tracy L. Spinrad Claire Hofer Laurie Chassin Qing Zhou Anne Kupfer Cynthia L. Smith Carlos Valiente Jeffrey Liew 《Social Development》2010,19(3):577-600
The relations of control/regulation‐related temperamentally based dispositions (effortful control (EC), impulsivity, and approach/avoidance) to externalizing problems and personality ego resiliency were examined in a sample of 467 children (M age = 7.46 years), some of whom were children of alcoholics (COAs). In addition, we examined if the relations of temperamental regulation/control to maladjustment/ego resiliency were moderated by COA status or sex of the child. In general, regulated, controlled temperament was negatively related to externalizing problems and EC was positively related to ego resiliency. Relations between a problematic temperament and externalizing problems were stronger and sometimes only found for COAs, especially male COAs. Ego resiliency was positively related to high father‐reported approach for boys who were not sons of alcoholics. In addition, COA status was related to high impulsivity, approach behavior, and externalizing problems and low EC. 相似文献
75.
Recent estimates suggest that as many as 1 in 200 adults may be trans (transgender, transsexual, or transitioned). Knowledge about dimensions of sex and gender in trans populations is crucial to development of inclusive policy, practice, and research, but limited data have been available, particularly from probability samples. The Trans PULSE community-based research project surveyed trans Ontarians (n = 433) in 2009–2010 using respondent-driven sampling. Frequencies were weighted by recruitment probability to produce estimates for the networked Ontario trans population. An estimated 30% of trans Ontarians were living their day-to-day lives in their birth gender, and 23% were living in their felt gender with no medical intervention. In all, 42% were using hormones, while 15% of male-to-female spectrum persons had undergone vaginoplasty and 0.4% of female-to-male spectrum persons had had phalloplasty. Of those living in their felt gender, 59% had begun to do so within the past four years. A minority of trans Ontarians reported a linear transition from one sex to another, yet such a trajectory is often assumed to be the norm. Accounting for this observed diversity, we recommend policy and practice changes to increase social inclusion and service access for trans persons, regardless of transition status. 相似文献
76.
Jean W. Bauer Tahira K. Hira Mari S. Wilhelm Karen P. Varcoe Saji Thomas 《Journal of Family and Economic Issues》1993,14(3):275-291
This study investigates the determinants of chronic health conditions that worry the member of rural couples who serves as the household financial manager. A sample of 1,115 rural couples from the NC-182 regional research project Family Resource Utilization as a Factor in Determining Economic Well-Being of Rural Families is used. The logit analysis finds that the probability of having a condition that worries the financial manager increases if she or he is middle aged or older, is not employed, and has external Locus of Control. This probability also increases when the dissatisfaction with the resources available to handle a financial emergency increases and the more often the financial manager does not have money to pay for the doctor.Preparation of this research was supported in part by the Minnesota Agricultural Experiment Station project 52–056 and the Minnesota Extension Service. Data were collected in conjunction with the cooperative regional research project NC-182, Family Resource Utilization as a Factor in Determining Economic Well-Being of Rural Families. Cooperating states are Arizona, California, Illinois, Indiana, Iowa, Kansas, Michigan, and Minnesota.Her current research interests include the economic well-being of various family forms. She received her Ph.D. from University of Illinois.Her current research interests include family financial management and consumer bankruptcy. She received her Ph.D. from the University of Missouri.Her current research interests include issues concerned with family stress management including financial stress. She received her Ph.D. at Michigan State University.Her current research interests include economic and environmental well-being for families and individuals with emphasis on the impact of environmental regulations on economic well-being. She received her Ph.D. from University of Illinois.His current interests include economic well-being of rural families. He was a research assistant for Dr. Bauer before receiving his Ph.D. degree in Agriculture and Applied Economics, University of Minnesota, St. Paul, MN. 相似文献
77.
This paper examines the relative savings position of migrant households in West Germany paying particular attention to differences
between temporary and permanent migrants. Our findings reveal significant differences in the savings rates between German
natives and immigrants. If remittances are treated as savings, however, migrants who intend to return to their home country
save significantly more than comparable natives. The results of a decomposition analysis indicate that slightly more than
half of the differences in the savings rate between Germans and permanent migrants and almost 70% between temporary and permanent
migrants can be attributed to differences in observable characteristics. 相似文献
78.
Yara Qutteina Catherine Nasrallah Laurie James-Hawkins Aasli Abdi Nur Kathryn M. Yount Monique Hennink Hanan F. Abdul Rahim 《Women and birth : journal of the Australian College of Midwives》2018,31(5):386-397
Background
Women’s mental health in the perinatal period is understudied worldwide and in Arab countries especially.Aim
This systematic review explores evidence of the association between women’s social resources for empowerment in the Arab World and their mental health in the prenatal and postnatal (≤1 year postpartum) periods.Methods
Guided by Kabeer’s framework of empowerment, the authors applied a search string in PubMed and Web of Science databases to identify studies in countries of the Arab League (hereafter the Arab World) that address mental health and social resources for women’s empowerment in the perinatal period.Findings
Of 1865 electronically retrieved articles, 23 met the inclusion criteria. Overall, the majority of studies found a positive association between social resources for empowerment and perinatal mental health. Seven studies explored the relationship between familial or general social support and prenatal mental health in Arab women, and found a significant positive association. Sixteen of the 18 studies of women in the postnatal period found that enabling familial, extra-familial, and/or general social support was positively associated with mental health.Conclusion
This review demonstrates an association between social resources and perinatal mental health, but there is a dearth of research in this area. We call for additional research on Arab women in the perinatal period using context-specific but standardized tools to assess social resources and mental health. Evidence on positive mental health, resilience, and the influence of social resources can guide the improvement of prenatal and postpartum care services. 相似文献79.
Mook Laurie Murdock Alex Gundersen Craig 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》2020,31(5):833-840
VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Food banks are a particular type of voluntary sector organization that bridges the government sector, private sector, and... 相似文献
80.