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111.
Integrins are cell surface receptors that mediate adhesion to the extracellular matrix. In this Perspective, we focus on the recent finding that a decrease in the levels of integrins yields fruit flies that retain youthful mobility as they age and display an increased mean life span. We discuss how the reduction of integrin activity might lead to the observed changes.  相似文献   
112.
Functional Capacity Evaluations (FCEs) have become the standard for identifying an individual's physical abilities and/or limitations following injury or illness. While philosophies and approaches differ, the focus of most FCE systems is to identify the individual's maximum capabilities. This article will discuss the usefulness of the FCE information and how FCEs are impacted by multiple factors including APTA guidelines, machine based testing, therapist expertise, medical legal credibility and court testimony, IMEs and FCE, and return to work/return to function.  相似文献   
113.
OBJECTIVE: The primary objectives of this study were to identify sources of meaning for individuals within the context of a work environment, and to compare varied sources of meaning for individuals with high and low work satisfaction levels. METHOD: Participants were chosen based on satisfaction levels in employment, full-time employment status within an organization for at least one year, and diversity in the work setting. Data were gathered through a series of interviews and observations of the participants' workplaces. A comparative analysis of transcribed interviews was conducted by the researchers and with an expert occupational therapy faculty panel. From these analyses, the researchers developed work narratives for a mechanical engineer, a high school teacher, an employee of mechanical services, and a career service counselor. RESULTS: Emerging themes from the work narratives indicated that the various meanings employees found in work had an effect on their perceived levels of job satisfaction. Participants conveyed that organization identification, financial benefits, independent decision-making, reciprocal respect, opportunities for creativity, and maintaining significant relationships outside of work enhanced meaning and satisfaction. CONCLUSIONS: The worker role is a significant source of an individual's identity, meaning, and satisfaction in life. Professionals in various fields can work with employers to develop meaningful work environments for increased job satisfaction, greater motivation for work, increased productivity, and decreased employee turnover.  相似文献   
114.
Volunteer labor is generally modeled as an individualistic pursuit, akin to leisure or to human capital accumulation. Some activities labeled as volunteering, however, may be more usefully thought of as quid pro quo time commitments that are part of securing services for family members. Parents are frequently expected to volunteer, for example, when their children participate in youth sports leagues or school marching bands. In such cases, volunteering is essentially an instance of household production undertaken outside the home. Using data from the Panel Study of Income Dynamics, we divide volunteering into three categories—youth-related, religious, and non-youth-related secular—according to the likelihood that an instance of volunteering in the category represents household production. We find evidence that husbands and wives respond to one another’s time pressures such that youth-related volunteering looks like a task for which husbands’ and wives’ time inputs substitute for one another. Further, we find this pattern for housework, and not for other forms of volunteering. An increase in either spouse’s hours of market work will significantly reduce that spouse’s likelihood of volunteering for youth-related activities while raising the partner’s likelihood of volunteering. A similar pattern holds for hours volunteered to youth-related activities, with the wife’s responses achieving statistical significance.  相似文献   
115.
Abstract

Bioethical debates contribute to discussions about the direction of healthcare funding as we enter the twenty - first century. The funding of healthcare is debated by economists, bioethicists and clinicians. Because of their practice experience and knowledge base social workers are also well-placed to contribute to such issues. The debate has taken place at the ‘macro’ rather than the ‘micro’ level. Yet many ethical decisions about healthcare are made at the patient's bedside. Are they procedural or clinical decisions? Are decisions made for a group or class of patient or on an individual basis? Answers for these questions are sought in a study of medical decision-making for head-injured patients admitted to the Intensive Care Unit of a major teaching hospital.

This paper attempts to draw out ethical principles which are part of medical decision-making. The notion of contextual ethics is likened to the ecological approach of Carel Germain which provides a useful framework for ethnomethodological research.  相似文献   
116.
In this interview with Bruce Perry, MD, PhD, Senior Fellow of The Child Trauma Academy, Laurie MacKinnon discusses with Dr Perry developmental trauma and the Neurosequential Model of Therapeutics, an approach to clinical problem solving that utilises a developmental lens and incorporates advances in neurobiological development. Dr Perry gives his perspective on the causal connection between childhood abuse and later psychiatric diagnosis, the child's contact with a violent parent post‐separation, the importance of interventions that address the organisation and functioning of lower parts of the brain and his perspective on the use and limitations of psychotropic medications, cognitive behaviour therapy and family therapy.  相似文献   
117.
Input‐output analysis is frequently used in studies of large‐scale weather‐related (e.g., Hurricanes and flooding) disruption of a regional economy. The economy after a sudden catastrophe shows a multitude of imbalances with respect to demand and production and may take months or years to recover. However, there is no consensus about how the economy recovers. This article presents a theoretical route map for imbalanced economic recovery called dynamic inequalities. Subsequently, it is applied to a hypothetical postdisaster economic scenario of flooding in London around the year 2020 to assess the influence of future shocks to a regional economy and suggest adaptation measures. Economic projections are produced by a macro econometric model and used as baseline conditions. The results suggest that London's economy would recover over approximately 70 months by applying a proportional rationing scheme under the assumption of initial 50% labor loss (with full recovery in six months), 40% initial loss to service sectors, and 10–30% initial loss to other sectors. The results also suggest that imbalance will be the norm during the postdisaster period of economic recovery even though balance may occur temporarily. Model sensitivity analysis suggests that a proportional rationing scheme may be an effective strategy to apply during postdisaster economic reconstruction, and that policies in transportation recovery and in health care are essential for effective postdisaster economic recovery.  相似文献   
118.
This paper is based on a study of women's transition from careers within organizations into self-employment. It focuses on three key issues: the ways in which women accounted for their career transition, their decisions to opt for self-employment, and the extent to which, in telling their stories, respondents engaged with emerging career discourses. First, this paper considers recent debates within the literature on women's exit from organizations, and emerging discourses of career and self-employment, focusing on the position of women within these changing discourses. Research findings are then presented, examining three central themes: entrepreneurial orientation, dissatisfaction with the organization and balance of personal and professional life. The concluding section considers how women made sense of the web of factors involved in their career transition and reflects on whether indeed it is 'time for a change'.  相似文献   
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