Fractional principal components regression: a general approach to biased estimators

Several biased estimators have been proposed as alternatives to the least squares estimator when multicollinearity is present in the multiple linear regression model. The ridge estimator and the principal components estimator are two techniques that have been proposed for such problems. In this paper the class of fractional principal component estimators is developed for the multiple linear regression model. This class contains many of the biased estimators commonly used to combat multicollinearity. In the fractional principal components framework, two new estimation techniques are introduced. The theoretical performances of the new estimators are evaluated and their small sample properties are compared via simulation with the ridge, generalized ridge and principal components estimators     

Semiparametric Estimators for Limited Dependent Variable (LDV) Models with Endogenous Regressors

This article reviews semiparametric estimators for limited dependent variable (LDV) models with endogenous regressors, where nonlinearity and nonseparability pose difficulties. We first introduce six main approaches in the linear equation system literature to handle endogenous regressors with linear projections: (i) ‘substitution’ replacing the endogenous regressors with their projected versions on the system exogenous regressors x, (ii) instrumental variable estimator (IVE) based on E{(error) × x} = 0, (iii) ‘model-projection’ turning the original model into a model in terms of only x-projected variables, (iv) ‘system reduced form (RF)’ finding RF parameters first and then the structural form (SF) parameters, (v) ‘artificial instrumental regressor’ using instruments as artificial regressors with zero coefficients, and (vi) ‘control function’ adding an extra term as a regressor to control for the endogeneity source. We then check if these approaches are applicable to LDV models using conditional mean/quantiles instead of linear projection. The six approaches provide a convenient forum on which semiparametric estimators in the literature can be categorized, although there are a few exceptions. The pros and cons of the approaches are discussed, and a small-scale simulation study is provided for some reviewed estimators.     

Robust mixture modeling using the skew <Emphasis Type="Italic">t</Emphasis> distribution

A finite mixture model using the Student's t distribution has been recognized as a robust extension of normal mixtures. Recently, a mixture of skew normal distributions has been found to be effective in the treatment of heterogeneous data involving asymmetric behaviors across subclasses. In this article, we propose a robust mixture framework based on the skew t distribution to efficiently deal with heavy-tailedness, extra skewness and multimodality in a wide range of settings. Statistical mixture modeling based on normal, Student's t and skew normal distributions can be viewed as special cases of the skew t mixture model. We present analytically simple EM-type algorithms for iteratively computing maximum likelihood estimates. The proposed methodology is illustrated by analyzing a real data example.     

Using CEO Succession to Integrate Acquired Organizations: A Contingency Analysis

The study proposes that organizations engaged in related acquisition may encourage CEO succession as a mechanism for integrating acquired organizations. Further, we suggest that the risk of CEO succession at the time of acquisition will vary based on the need for integrative action and the power of acquired organizations. Results show that CEO succession is more likely when the participating organizations have incompatible types of ownership and when acquired CEOs have longer tenure than their counterparts. Conversely, the probability of CEO succession is lower among larger acquired organizations. Performance of the acquired organization does not affect the relationship between related acquisition and CEO succession.     

Autoregressive model selection based on a prediction perspective

The autoregressive (AR) model is a popular method for fitting and prediction in analyzing time-dependent data, where selecting an accurate model among considered orders is a crucial issue. Two commonly used selection criteria are the Akaike information criterion and the Bayesian information criterion. However, the two criteria are known to suffer potential problems regarding overfit and underfit, respectively. Therefore, using them would perform well in some situations, but poorly in others. In this paper, we propose a new criterion in terms of the prediction perspective based on the concept of generalized degrees of freedom for AR model selection. We derive an approximately unbiased estimator of mean-squared prediction errors based on a data perturbation technique for selecting the order parameter, where the estimation uncertainty involved in a modeling procedure is considered. Some numerical experiments are performed to illustrate the superiority of the proposed method over some commonly used order selection criteria. Finally, the methodology is applied to a real data example to predict the weekly rate of return on the stock price of Taiwan Semiconductor Manufacturing Company and the results indicate that the proposed method is satisfactory.     

Automatic polynomial wavelet regression

In Oh, Naveau and Lee (2001) a simple method is proposed for reducing the bias at the boundaries for wavelet thresholding regression. The idea is to model the regression function as a sum of wavelet basis functions and a low-order polynomial. The latter is expected to account for the boundary problem. Practical implementation of this method requires the choice of the order of the low-order polynomial, as well as the wavelet thresholding value. This paper proposes two automatic methods for making such choices. Finite sample performances of these two methods are evaluated via numerical experiments.     

The analysis of the AB/BA cross‐over trial in the medical literature

The evolution of opinion as to how to analyse the AB/BA cross‐over trials is described by examining the recommendations of three key papers. The impact of these papers on the medical literature is analysed by looking at citation rates as a function of various factors. It is concluded that amongst practitioners there is a highly imperfect appreciation of the issues raised by the possibility of carry‐over. Copyright © 2004 John Wiley & Sons, Ltd.     

A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies

Optimal design methods have been proposed to determine the best sampling times when sparse blood sampling is required in clinical pharmacokinetic studies. However, the optimal blood sampling time points may not be feasible in clinical practice. Sampling windows, a time interval for blood sample collection, have been proposed to provide flexibility in blood sampling times while preserving efficient parameter estimation. Because of the complexity of the population pharmacokinetic models, which are generally nonlinear mixed effects models, there is no analytical solution available to determine sampling windows. We propose a method for determination of sampling windows based on MCMC sampling techniques. The proposed method attains a stationary distribution rapidly and provides time-sensitive windows around the optimal design points. The proposed method is applicable to determine sampling windows for any nonlinear mixed effects model although our work focuses on an application to population pharmacokinetic models.     

Maximum likelihood estimation in a model with interval data

It is suggested that in some situations, observations for random variables should be collected in the form of intervals. In this paper, the unknown parameters in a bivariate normal model are estimated based on a set of point and interval observations via the maximum likelihood approach. The Newton-Raphson algorithm is used to find the estimates, and asymptotic properties of the estimator are provided. Monte Carlo studies are conducted to study the performance of the estimator. An example based on real-life data is presented to demonstrate the practical applicability of the method.