Noninformative priors for linear combinations of the normal means

In this paper, we develop noninformative priors for linear combinations of the means under the normal populations. It turns out that among the reference priors the one-at-a-time reference prior satisfies a second order probability matching criterion. Moreover, the second order probability matching priors match alternative coverage probabilities up to the second order and are also HPD matching priors. Our simulation study indicates that the one-at-a-time reference prior performs better than the other reference priors in terms of matching the target coverage probabilities in a frequentist sense.     

New Confidence Intervals for the Proportion of Interest in One-Sample Correlated Binary Data

Correlated binary data is obtained in many fields of biomedical research. When constructing a confidence interval for the proportion of interest, asymptotic confidence intervals have already been developed. However, such asymptotic confidence intervals are unreliable in small samples. To improve the performance of asymptotic confidence intervals in small samples, we obtain the Edgeworth expansion of the distribution of the studentized mean of beta-binomial random variables. Then, we propose new asymptotic confidence intervals by correcting the skewness in the Edgeworth expansion in one direct and two indirect ways. New confidence intervals are compared with the existing confidence intervals in simulation studies.     

Is Each NPMLE of a Continuous Bivariate Distribution Function with Singly Right-Censored Data Really Inconsistent?

We consider non-parametric estimation of a continuous cdf of a random vector (X ₁, X ₂). With bivariate RC data, it is stated in van der Laan (1996 Van der Laan , M. J. ( 1996 ) Efficient estimation in the bivariate censoring model and repairing NPMLE . Ann. Statist. 24 : 596 – 627 .[Crossref], [Web of Science ®] , [Google Scholar], p. 598¹⁰, Ann. Statist.), Quale et al. (2006 Quale , C. M. , van der Laan , M. J. , Robins , J. R. ( 2006 ). Locally efficient estimation with bivariate right-censored data . JASA. 101 : 1076 – 1084 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar], JASA) etc. that “it is well known that the NPMLE for continuous data is inconsistent (Tsai et al. (1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar])).” The claim is based on a result in Tsai et al. (1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar], p.1352, Ann. Statist.) that if X ₁ is right censored but not X ₂, then common ways for defining one NPMLE lead to inconsistency. If X ₁ is right censored and X ₂ is type I right-censored (which includes the case in Tsai et al.), we present a consistent NPMLE. The result corrects a common misinterpretation of Tsai's example (Tsai et al., 1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar], Ann. Statist.).     

Constrained optimal designs for regressiom models

An attempt of combining several optimality criteria simulaneously by using the techniques of nonliear programming is demonstrated. Four constrained D- and G-optimality criteria are introduced, namely, D-restrcted, D_s-restricted, A-restricted and E-restricted D- and G-optimality. The emphasis is particularly on the polynomial regression. Examples for quadratic polynomial regression are investigated to illustrate the applicability of these constrained optimality criteria.     

Identification of target clusters by using the restricted normal mixture model

This paper addresses the problem of identifying groups that satisfy the specific conditions for the means of feature variables. In this study, we refer to the identified groups as “target clusters” (TCs). To identify TCs, we propose a method based on the normal mixture model (NMM) restricted by a linear combination of means. We provide an expectation–maximization (EM) algorithm to fit the restricted NMM by using the maximum-likelihood method. The convergence property of the EM algorithm and a reasonable set of initial estimates are presented. We demonstrate the method's usefulness and validity through a simulation study and two well-known data sets. The proposed method provides several types of useful clusters, which would be difficult to achieve with conventional clustering or exploratory data analysis methods based on the ordinary NMM. A simple comparison with another target clustering approach shows that the proposed method is promising in the identification.     

Mobile safety cameras: estimating casualty reductions and the demand for secondary healthcare

We consider a fully Bayesian analysis of road casualty data at 56 designated mobile safety camera sites in the Northumbria Police Force area in the UK. It is well documented that regression to the mean (RTM) can exaggerate the effectiveness of road safety measures and, since the 1980s, an empirical Bayes (EB) estimation framework has become the gold standard for separating real treatment effects from those of RTM. In this paper we suggest some diagnostics to check the assumptions underpinning the standard estimation framework. We also show that, relative to a fully Bayesian treatment, the EB method is over-optimistic when quantifying the variability of estimates of casualty frequency. Implementing a fully Bayesian analysis via Markov chain Monte Carlo also provides a more flexible and complete inferential procedure. We assess the sensitivity of estimates of treatment effectiveness, as well as the expected monetary value of prevention owing to the implementation of the safety cameras, to different model specifications, which include the estimation of trend and the construction of informative priors for some parameters.     

Stratification of randomization is not required for a pre‐specified subgroup analysis

Published literature and regulatory agency guidance documents provide conflicting recommendations as to whether a pre‐specified subgroup analysis also requires for its validity that the study employ randomization that is stratified on subgroup membership. This is an important issue, as subgroup analyses are often required to demonstrate efficacy in the development of drugs with a companion diagnostic. Here, it is shown, for typical randomization methods, that the fraction of patients in the subgroup given experimental treatment matches, on average, the target fraction in the entire study. Also, mean covariate values are balanced, on average, between treatment arms in the subgroup, and it is argued that the variance in covariate imbalance between treatment arms in the subgroup is at worst only slightly increased versus a subgroup‐stratified randomization method. Finally, in an analysis of variance setting, a least‐squares treatment effect estimator within the subgroup is shown to be unbiased whether or not the randomization is stratified on subgroup membership. Thus, a requirement that a study be stratified on subgroup membership would place an artificial roadblock to innovation and the goals of personalized healthcare. Copyright © 2012 John Wiley & Sons, Ltd.     

A Versatile One-Dimensional Distribution Plot: The BLiP Plot

A versatile graphical tool, the BLiP plot, was developed for displaying one-dimensional data. The basic building blocks are boxes, lines, and points. Like many standard one-dimensional distribution plots, the BLiP plot is capable of displaying individual data values in points or lines and grouped information in lines or boxes. In addition, the BLiP plot includes many new features such as variable-width plots and several choices of point patterns. The main advantage of the BLiP plot is that it provides users with basic graphical elements in a friendly and flexible environment so that users can, according to their needs, construct anything from a simple, standard plot to a complex, customized plot to best present their data.     

Alternative estimator for the parameters of a mixture of two binomial distributions

The method of moments has been widely used as a simple alternative to the maximum likelihood method, mainly because of its efficiency and simplicity in obtaining parameter estimators of a mixture of two binomial distributions. In this paper, an alternative estimate is proposed which is as competitive as of the method of moments when comparing the mean squared error and computational effort.     

On the Cusum test for parameter changes in garch(1,1) Models

This paper considers the problem of testing parameter constancy in GARCH(1,1) models. A cusum of squares test is propesed in analogy Of Incl´n and Tiao (1394)'s statistic. its limiting distribution is derived via using the invariance principle for mixingaie sequences obtained by McLeish(1975). Simulation results are illustrated to demonstrate the validity of the cusum test.