An Empirical Approach to Sufficient Similarity: Combining Exposure Data and Mixtures Toxicology Data

When assessing risks posed by environmental chemical mixtures, whole mixture approaches are preferred to component approaches. When toxicological data on whole mixtures as they occur in the environment are not available, Environmental Protection Agency guidance states that toxicity data from a mixture considered “sufficiently similar” to the environmental mixture can serve as a surrogate. We propose a novel method to examine whether mixtures are sufficiently similar, when exposure data and mixture toxicity study data from at least one representative mixture are available. We define sufficient similarity using equivalence testing methodology comparing the distance between benchmark dose estimates for mixtures in both data‐rich and data‐poor cases. We construct a “similar mixtures risk indicator”(SMRI) (analogous to the hazard index) on sufficiently similar mixtures linking exposure data with mixtures toxicology data. The methods are illustrated using pyrethroid mixtures occurrence data collected in child care centers (CCC) and dose‐response data examining acute neurobehavioral effects of pyrethroid mixtures in rats. Our method shows that the mixtures from 90% of the CCCs were sufficiently similar to the dose‐response study mixture. Using exposure estimates for a hypothetical child, the 95th percentile of the (weighted) SMRI for these sufficiently similar mixtures was 0.20 (i.e., where SMRI <1, less concern; >1, more concern).     

The Effects of Nursing Home Placement on the Perceived Levels of Caregiver Burden

Providing care for an aging parent can be one of the most fulfilling life experiences for an adult child. It can also be one of the most exhausting physically, emotionally, and financially. A caregiver experiences psychological and emotional changes when their dependent parent or spouse is placed into formal care. This research project uses the Montgomery Borgatta Caregiver Burden Scale, amended with a questionnaire, in a self-administered, anonymous survey to explore perceptions of caregiving burden before and after the nursing home placement periods. This research showed that numerous factors influence caregivers' perceptions of burden and the quality of relationships among family members.     

Perceptions of Benzodiazepine Dependence Among Women Age 65 and Older

A phenomenological study explored whether older women who are chronic benzodiazepine users identified themselves as dependent, how dependence was perceived, and how meanings and understandings shaped experiences of benzodiazepine use. Self-reported benzodiazepine dependence was associated with being unable to reduce use or a desire to discontinue use and reliance on benzodiazepines to remain comfortable and able to handle daily life. Themes included: (a) benzodiazepine dependence is similar to dependence to diabetes or blood pressure medications; (b) dependence is distinctive from addiction/abuse; (c) addiction/abuse is perceived as worse than dependence; and (d) concerns of addiction/abuse result in low-dose benzodiazepine use.     

给老乡外送礼的技巧

有些跨文化交往的游戏规则，如果你不知道的话，你善良的本意极有可能会被人误以为是恶劣的人格体现     

Acculturative Stress and Mental Health Among Korean Adolescents in the United States

This study investigated Korean-American adolescents' stress related to their acculturation experiences and mental health. A total of 260 Korean-American adolescents from immigrant families (ages 12–18 years) participated in the study. The U.S. born group had a higher level of acculturative stress than the Korea-born group (t = 2.222; df = 258; p < .05). Males reported a higher level of self-esteem than females (t = ?2.112; df = 257; p < .05). Acculturative stress was positively correlated with depression (r = .299; p < .01) and negatively related to self-esteem (r = ?.292; p < .01). Self-esteem was negatively related to depression (r = ?.536; p < .01).     

Community standards,conservatism, and judgments of pornography

In an attempt to determine if a community standard existed and to relate judgments of pornography to conservatism, scores on Wilson and Patterson's Conservatism Scale, yes‐no judgments on whether 25 pictures were or were not pornographic, and demographic data were obtained from a random sample (N = 114) of a community. Results were as follows: (1) suggestive evidence for the existence of a community standard; (2) the c‐scale correlated .57 (N = 114, p < .01) with number of pictures judged pornographic; (3) the 25 pictures met Guttman requirements of unidimensionality (reproducibility of .925); and (4) factor analysis of the pornography judgments yielded three clear‐cut factors and one ambiguous factor which were ordered along the Guttman dimension.     

出生性别比综合治理:有所为,有所不为

从1980年我国出生性别比越过正常值域至今,党和各级政府制订了种种措施进行综合治理,但取得的成效甚微。这一时期我国治理工作的特点有:重视禁止性法律法规的制定,但与之相配套的规章制度比较缺乏;重视目标任务的提出,但落实目标的措施比较缺乏;部门性、专项性规章制度较多,综合性规章制度比较缺乏。今后一段时期内综合治理工作,可以按照避实就虚、避难就易的原则,在大力发展社会经济、建立健全社会养老制度、相关法律法规的制定与完善、加大对两非行为的打击力度等方面有所作为;而在人口生育政策的调整、传统文化的改变等方面有所不为。