Epidemiologic network inference

Statistics and Computing - In many epidemiologic models, a disease is assumed to spread along a contact network. We aim to infer this network, in addition to the epidemiologic model parameters,...     

When is a seamless study desirable? Case studies from different pharmaceutical sponsors

Background: Inferentially seamless studies are one of the best‐known adaptive trial designs. Statistical inference for these studies is a well‐studied problem. Regulatory guidance suggests that statistical issues associated with study conduct are not as well understood. Some of these issues are caused by the need for early pre‐specification of the phase III design and the absence of sponsor access to unblinded data. Before statisticians decide to choose a seamless IIb/III design for their programme, they should consider whether these pitfalls will be an issue for their programme. Methods: We consider four case studies. Each design met with varying degrees of success. We explore the reasons for this variation to identify characteristics of drug development programmes that lend themselves well to inferentially seamless trials and other characteristics that warn of difficulties. Results: Seamless studies require increased upfront investment and planning to enable the phase III design to be specified at the outset of phase II. Pivotal, inferentially seamless studies are unlikely to allow meaningful sponsor access to unblinded data before study completion. This limits a sponsor's ability to reflect new information in the phase III portion. Conclusions: When few clinical data have been gathered about a drug, phase II data will answer many unresolved questions. Committing to phase III plans and study designs before phase II begins introduces extra risk to drug development. However, seamless pivotal studies may be an attractive option when the clinical setting and development programme allow, for example, when revisiting dose selection. Copyright © 2014 John Wiley & Sons, Ltd.     

Video Deficit in Toddlers’ Object Retrieval: What Eye Movements Reveal About Online Cognition

The purpose of this study was to determine whether toddlers exhibit different eye‐movement patterns when watching real events versus video demonstrations in an object‐retrieval task. Twenty‐four‐month‐olds (N = 36) searched for a sticker on a felt board after watching an experimenter hide it behind a felt object in person or via video. Eye movements during the hiding event were recorded. Compared to those watching in‐person events, children watching video spent more time looking at the target location overall, yet they had relatively poor search performance. Visual attention to the target location predicted search performance in the video condition only; children who watched in‐person hiding events had high success rates even if they paid relatively little visual attention to the correct location. Findings are consistent with the hypothesis that toddlers process information more quickly for in‐person (versus video) events, enabling them to learn as well (or better) despite relatively low selective attention. Thus, relatively poor encoding, as well as memory retrieval, may underlie the video deficit.     

Women's Engagement in Pubic Hair Removal: Motivations and Associated Factors

Objectives: To examine the relationship between women's pubic hair removal (PHR) and genital satisfaction and explore whether attitudes toward, and personal consumption of, pornography are associated with women's engagement in PHR. Methods: Data were collected by online survey from women (N = 152) who were then categorized into groups based on the prevalence and extent of PHR during the previous 4 weeks. Groups were compared on demographic, background, and behavioral variables. Results: Eighty-three percent of respondents reported PHR in the previous 4 weeks and 40% of respondents removed all their pubic hair. Women who were younger, White, and were more satisfied with their genitals were more likely to engage in PHR. Of these, being younger, not having a degree, reporting less positive attitudes toward erotica, and 3 reasons for PHR predicted extensive PHR over limited removal. Conclusions: Findings provide insights into the reasons for, and extent of, PHR among women and factors associated with the practice. The possible influences of partners' preferences for genital hair removal by women and partners' consumption of pornography are important areas for future research.     

A Gendered Assessment of Highly Skilled Emigration

Although women form a large and increasing proportion of international migrants, women's mobility has generally been overlooked in the literature. Quantifying and characterizing female migration should lead to a better understanding of the forces that shape international migration. We build an original data set providing gender‐disaggregated indicators of international migration by educational attainment for 195 source countries in 1990 and 2000. We find that women represent an increasing share of the immigration stock in the OECD countries and exhibit higher skilled emigration rates than men.     

The Evolution of Culture and Sociology

Orthodox neo-Darwinians have typically sought to explain human pro-social behavior by invoking kin altruism and reciprocal altruism, principles that explain the pro-social behavior of non-human species. These principles, however, do not account for those features of our species that are most unique and of greatest importance to sociologists—our group identities and behavior, our cognitive and behavioral plasticity, our capacity for social learning and cumulative culture, among other things. This article describes the efforts of “dual inheritance” theorists to overcome the deficiencies of orthodox neo-Darwinism by developing an evolutionary theory of culture, a theory that also seeks to account for human “groupishness,” intelligence, language use, empathy, morality and religion. The article asserts that dual inheritance theory accommodates most of the traditional research interests of sociologists while proving a robust explanatory framework and that sociologists are positioned especially well to contribute to the study of the evolution of culture.     

The Effects of Mandatory Seat Belt Laws on Motor Vehicle Fatalities in the United States

Objective . This article assesses the effectiveness of mandated seat belt usage. The theory of offsetting behavior asserts that when drivers feel safer, they compensate by driving less cautiously. As a consequence, any lifesaving effects from mandated safety devices such as seat belts could be significantly diminished or entirely offset. Methods . This article uses regression analysis and two years (1988 and 1997) of state-level data to test for the presence of offsetting behavior by estimating models explaining total and nonoccupant motor vehicle deaths. In addition to accounting for several factors generally acknowledged as being determinants of highway deaths, the models control for the impact of primary and secondary seat belt laws. Results . The findings suggest the existence of offsetting behavior by drivers of motor vehicles. Conclusions . We need to recognize the probability of such compensatory behavior and direct our efforts at ways of ameliorating the adverse effects.