Assessing Potential Human Health Hazards and Benefits from Subtherapeutic Antibiotics in the United States: Tetracyclines as a Case Study

Many scientists, activists, regulators, and politicians have expressed urgent concern that using antibiotics in food animals selects for resistant strains of bacteria that harm human health and bring nearer a “postantibiotic era” of multidrug resistant “super‐bugs.” Proposed political solutions, such as the Preservation of Antibiotics for Medical Treatment Act (PAMTA), would ban entire classes of subtherapeutic antibiotics (STAs) now used for disease prevention and growth promotion in food animals. The proposed bans are not driven by formal quantitative risk assessment (QRA), but by a perceived need for immediate action to prevent potential catastrophe. Similar fears led to STA phase‐outs in Europe a decade ago. However, QRA and empirical data indicate that continued use of STAs in the United States has not harmed human health, and bans in Europe have not helped human health. The fears motivating PAMTA contrast with QRA estimates of vanishingly small risks. As a case study, examining specific tetracycline uses and resistance patterns suggests that there is no significant human health hazard from continued use of tetracycline in food animals. Simple hypothetical calculations suggest an unobservably small risk (between 0 and 1.75E‐11 excess lifetime risk of a tetracycline‐resistant infection), based on the long history of tetracycline use in the United States without resistance‐related treatment failures. QRAs for other STA uses in food animals also find that human health risks are vanishingly small. Whether such QRA calculations will guide risk management policy for animal antibiotics in the United States remains to be seen.     

Editorial: Cognitive science,occupational stress and organizational health

A number of studies have shown that musculoskeletal symptoms are related to the physical and psychosocial work environments. Workers with musculoskeletal symptoms are often advised to cope by such measures as changing working technique, using lifting equipment and discussing health and environmental problems with supervisors and colleagues. Intervention studies at the individual level, however, have shown that such advice has limited effects in reducing the prevalence of musculoskeletal symptoms. The hypothesis for this study was that negative social and organizational factors may prevent workers from implementing such coping strategies. All 103 motor vehicle mechanics surveyed in 12 different garages responded to a questionnaire on coping with musculoskeletal symptoms and the psychosocial work environment. Positive and significant relationships were shown between how mechanics coped with their musculoskeletal symptoms and such psychosocial factors as work demands, social support, control, manager's involvement in health and safety work, and whether the garages had regular meetings between management and workers. Achieving positive results from preventive work through back schools and other ergonomic interventions seems to require that an organization with positive attitudes towards health and safety work be created before such interventions are implemented.     

Detecting Overdispersion in Large Scale Surveys: Application to a Study of Education and Social Class in Britain (with Comments)

A practical problem with large scale survey data is the potential for overdispersion. Overdispersion occurs when the data display more variability than is predicted by the variance–mean relationship for the assumed sampling model. This paper describes a simple strategy for detecting and adjusting for overdispersion in large scale survey data. The method is primarily motivated by data on the relationship between social class and educational attainment obtained from a 2% sample from the 1991 census of the population of Great Britain. Overdispersion can be detected by first grouping the data into a number of strata of approximately equal size. Under the assumption that the observations are independent and there is no variability in the parameter of interest, there is a direct relationship between the nominal standard errors and the empirical or sample standard deviation of the parameter estimates obtained from each of the separate strata. With the 2% sample from the British census data, quite a discernible departure from this relationship was found, indicating overdispersion. After allowing for overdispersion, improved and more realistic measures of precision of the strength of the social class–education associations were obtained.     

Discrete Probability Distributions for Probabilistic Fracture Mechanics

Recently, discrete probability distributions (DPDs) have been suggested for use in risk analysis calculations to simplify the numerical computations which must be performed to determine failure probabilities. Specifically, DPDs have been developed to investigate probabilistic functions, that is, functions whose exact form is uncertain. The analysis of defect growth in materials by probabilistic fracture mechanics (PFM) models provides an example in which probabilistic functions play an important role. This paper compares and contrasts Monte Carlo simulation and DPDs as tools for calculating material failure due to fatigue crack growth. For the problem studied, the DPD method takes approximately one third the computation time of the Monte Carlo approach for comparable accuracy. It is concluded that the DPD method has considerable promise in low-failure-probability calculations of importance in risk assessment. In contrast to Monte Carlo, the computation time for the DPD approach is relatively insensitive to the magnitude of the probability being estimated.     

Preventing child abuse; a review of community-based projects 1. Intervening on processes and outcome of reviews

Recent theories advocating ecological and developmental perspectives on child abuse and neglect are summarized. Reviews of community prevention programmes underline the importance of focusing on processes and viewing the developing child and their family in a broad context. The conclusions of the reviews are reported. Although the reviews suggest that some programmes to prevent physical and sexual abuse and bullying are at least to some degree effective, their impact has been reduced by a failure to encompass adequately the various influences that operate across difference domains of the child's life at different stages of their development. © 1997 John Wiley & Sons, Ltd.     

‘Privacy does not interest me’. A comparative analysis of photo sharing on Instagram and Blipfoto

Photo sharing online has become immensely popular and is a central aspect of modern visual culture. Yet it creates a number of privacy issues, both in relation to other individuals and corporate surveillance. The purpose of this study was to investigate users’ understanding of privacy issues in photo sharing, based on a comparative study of two contrasting platforms: Instagram and Blipfoto. The study combined netnography and in-depth interviewing. It was found that Instagram users had a greater awareness of how the platform might use their data, but saw this loss of privacy as inevitable in return for a free service. Blipfoto users were more trusting of what they experienced as a very community minded platform. Any concerns felt by both groups of users were out-weighed by the sense that photo sharing was highly meaningful and their fascination with watching and being watched. Both groups main approach to privacy was through restricting certain types of image of people and not revealing the location of certain personal spaces. Notions of privacy thus remained primarily personal and ignored corporate dataveillance.     

Relations Among Intimate Partner Violence,Maternal Depressive Symptoms,and Maternal Parenting Behaviors

The authors examined the relations among intimate partner violence (IPV), maternal depressive symptoms, and maternal harsh intrusive parenting. Using a cross‐lagged, autoregressive path model, they sought to clarify the directionality of the relations among these 3 variables over the first 2 years of the child's life. The results indicated that, in this diverse sample of families living in predominantly low‐income rural communities (N = 705), higher levels of early IPV were associated with increases in maternal depressive symptoms, which in turn were associated with increases in maternal harsh intrusive parenting behaviors. These findings suggest that interventions aimed at improving the parenting of women exposed to domestic violence may want to simultaneously target IPV and depressive symptomatology.