Computing exact one-sided confidence limits for treatment effect in clinical trials

One standard summary of a clinical trial is a confidence limit for the effect of the treatment. Unfortunately, standard approximate limits may have poor frequentist properties, even for quite large sample sizes. It has been known since Buehler (1957 Buehler, R. J. (1957). Confidence intervals for the product of two binomial parameters. Journal of Computational and Graphical Statistics 52:482–493. [Google Scholar]) that an imperfect confidence limit can be adjusted to have exact coverage. These “tight” limits are the gold standard frequentist confidence limit. Computing tight limits requires exact calculation of certain tail probabilities and optimisation of potentially erratic functions of the nuisance parameter. Naive implementation is both computationally unreliable and highly burdensome, and perhaps explains why they are not in common use. For clinical trials however, where the data and parameter have dimension two, the difficulties can be fully surmounted. This paper brings together several results in the area and applies them to simple two dimensional problems. It is shown how to reduce the computational burden by an order of magnitude. Difficulties with the optimisation reliability are mitigated by applying two different computational strategies, which tend to break down under different conditions, and taking the less stringent of the two computed limits. This paper specifically develops limits for the relative risk in a clinical trial, but it should be clear to the reader that the method extends to arbitrary measures of treatment effect without essential modification.     

Preparing social workers for practice with LGBT populations affected by substance use: perceptions from students,alumni, and service providers

Trends in the field of service among those with alcohol and other drug addictions highlight the urgent need for schools of social work to effectively train students to serve clients with substance use disorders, and have cultural humility to effectively serve disproportionately affected LGBT consumers. Online surveys and interviews examined perceptions of graduate social work students and alumni in a certified alcohol and drug counselor program, along with several service providers within an urban setting in the US. Results indicated that students and alumni did not feel adequately prepared through coursework to practice with LGBT populations affected by substance use, while feeling more clinically competent to practice with LGB individuals, than with transgender consumers. Similar findings related to unique differences associated with perceptions of faculty support, along with field preparedness to practice with LGB individuals when compared to transgender individuals. Service providers noted an overall commitment and to serve LGBT consumers as well as positive perceptions of students and alumni to do the same. Implications examine the role of faculty in addressing challenges related to preparation of social work students to practice with LGBT consumers affected by substance use disorders, along with suggestions for curricular changes, and ongoing field trainings.     

The Role of Labeling and Bias in the Portrayals of Acts of “Terrorism”: Media Representations of Muslims vs. Non-Muslims

Several high-profile negative events involving Muslim perpetrators have recently been covered by the media. We investigated whether the same negative actions are more likely to be labeled “terrorism” when they are committed by Muslims than when they are committed by White non-Muslims. In Experiment I (n?=?60), using a real article about a Muslim perpetrator and a modified version about a non-Muslim perpetrator, we found that participants were more likely to identify a crime as terrorism when it was perpetrated by a Muslim. The label “terrorism” also mediated the effect of Muslim identity on negative judgments of the behavior. In Experiment II (n?=?60), we replicated the results of Experiment I and clarified that the effects persisted when we used a real article about a non-Muslim perpetrator and a modified version about a Muslim perpetrator. We discuss implications for cross-group communication and representations of Muslims in the media.     

The size accuracy of combination tests

Adaptive clinical trials typically involve several independent stages. The P‐values from each stage are synthesized through a so‐called combination function which ensures that the overall test will be valid if the stagewise tests are valid. In practice however, approximate and possibly invalid stagewise tests are used. This paper studies how imperfections of the stagewise tests feed through into the combination test. Several general results are proven including some for discrete models. An approximation formula which directly links the combined size accuracy to the component size accuracy is given. In the wider context of adaptive clinical trials, the main conclusion is that the basic tests used should be size accurate at nominal sizes both much larger and also much smaller than nominal desired size. For binary outcomes, the implication is that the parametric bootstrap should be used.     

社会学中的多元文化主义和民族多元主义——碎片化理论回顾与评述

社会学界目前存在着一种将多元文化主义视为推动社会碎片化的话语。根据社会学理论对多元文化主义(或民族/文化多元主义)进行情境化解读,厘清以不同社会凝聚为基础的多元文化主义概念化方式。选取过去的三四十年间,加拿大和欧洲主要社会学家的体现了碎片化多元文化主义的作品进行分析。不仅对多元文化主义碎片化观点进行描述,同时还采用"知识社会学"的方法对其观点进行分析。最后讨论并总结了这些论点在政策上可能产生的影响。     

A comparison of suicide patterns in Australia and Hong Kong

We analyse the patterns of 6564 suicides in Hong Kong and 23671 suicides in Australia for the period 1981–1993. Within the unifying framework of logistic regression we investigate how suicide rates vary with marital status and age and how these patterns vary over time and between the two cultures. The main significant differences between the two cultures are that rates are higher in Australia, rates for males are much higher than for females in Australia but only slightly higher in Hong Kong, in Hong Kong the oldest age group has the highest suicide rate unlike in Australia and the protective effects of marriage are larger in Australia.     

How Do We Communicate About Pain? A Systematic Analysis of the Semantic Contribution of Co-speech Gestures in Pain-focused Conversations

The purpose of the present study was to investigate co-speech gesture use during communication about pain. Speakers described a recent pain experience and the data were analyzed using a ‘semantic feature approach’ to determine the distribution of information across gesture and speech. This analysis revealed that a considerable proportion of pain-focused talk was accompanied by gestures, and that these gestures often contained more information about pain than speech itself. Further, some gestures represented information that was hardly represented in speech at all. Overall, these results suggest that gestures are integral to the communication of pain and need to be attended to if recipients are to obtain a fuller understanding of the pain experience and provide help and support to pain sufferers.     

Homophobia within schools of social work: the critical need for affirming classroom settings and effective preparation for service with the LGBTQ community

Social work programs must effectively meet the needs of their diverse lesbian, gay, bisexual, transgender, and queer (LGBTQ) student populations as well as effectively train all students to work with minority groups including the LGBTQ community. While many undergraduate and graduate social work programs provide open, supportive, and affirming experiences for LGBTQ students, there remain ongoing challenges related to hostility, stigma, heterosexism, and homophobia within classroom settings across programs in the US and Canada. This study examines classroom experiences of homophobia among 1,018 social work students. Qualitative data associated with three optional open-ended questions were analyzed utilizing grounded theory. Main qualitative findings identified several major themes associated with social work student experiences of homophobia in the classroom including: (1) Coming out; (2) Faculty inaction; (3) Implicit and explicit content; (4) Direct language and actions; and (5) Religious rationalizations and non-affirming positions. Conclusions and recommendations for social work education are discussed that center around creating safe and affirming classroom settings; the vital role of out faculty, students, and allies; impactful integration of diversity content within curricula, policies, and accreditation standards; ongoing training and mentorship; understanding the role of power and oppression; and a call to action among social work educators and the profession.     

Imagining their Future Selves: Children's Attitudes to Older People and their Expectations of Life at Age 70

Studies eliciting the views of children on ageing are rare, particularly those that focus on imagining a future self as an ‘old’ person and how this might be linked to current attitudes to older people. To address this gap, 2,365 children participated in an online survey which included questions on ageing. Findings suggest that children who hold negative views about old people visualise poorer outcomes for themselves at age 70. Implications of the findings are discussed in the context of an ageing population and the need to develop strategies to prevent the formation of prejudices against older people from an early age.