A Bayesian approach for generalized linear models with explanatory biomarker measurement variables subject to detection limit: an application to acute lung injury

Biomarkers have the potential to improve our understanding of disease diagnosis and prognosis. Biomarker levels that fall below the assay detection limits (DLs), however, compromise the application of biomarkers in research and practice. Most existing methods to handle non-detects focus on a scenario in which the response variable is subject to the DL; only a few methods consider explanatory variables when dealing with DLs. We propose a Bayesian approach for generalized linear models with explanatory variables subject to lower, upper, or interval DLs. In simulation studies, we compared the proposed Bayesian approach to four commonly used methods in a logistic regression model with explanatory variable measurements subject to the DL. We also applied the Bayesian approach and other four methods in a real study, in which a panel of cytokine biomarkers was studied for their association with acute lung injury (ALI). We found that IL8 was associated with a moderate increase in risk for ALI in the model based on the proposed Bayesian approach.     

RIVERINE CROSSINGS: GENDER,IDENTITY AND THE RECONSTRUCTION OF NATIONAL MYTHIC NARRATIVE IN THE CRYING GAME

The Crying Game's central, tragic theme of warrior/lovers caught between their love for one another and loyalty to their respective factions has significant roots in early Celtic mythology. The elegaic theme of potential lovers forced into ill-fated combat that frames the film's events also, significantly, bears the weight of the film's most unambiguous political commentary, when Fergus speaks directly to the picture of Jody in Dil's apartment, telling him: ‘You should have stayed at home.’ This sad remonstration, which clearly lays responsibility for the chain of causality that has led to so much suffering not with Jody, but with the British state, is similar in quality to Cu Chulainn's lament as he contemplates his meeting with Ferdia. When we listen carefully for ways in which Celtic mythical themes underlie and nuance the film's events, different rhythms emerge, accenting different beats.     

Childhood Sexual Abuse Severity Reconsidered: A Factor Structure of CSA Characteristics

To address the lack of empirically grounded measures of childhood sexual abuse severity, a survey of self-report items was developed following a thorough review of the childhood sexual abuse literature. An exploratory factor analysis was conducted using data collected from a convenience sample of college students that included 275 females and males with a history of childhood sexual abuse. The solution produced seven factors interpreted as the following: (a) less intrusive forms of childhood sexual abuse (e.g., sexual invitations, kissing), (b) more intrusive forms of childhood sexual abuse (e.g., oral sex, intercourse), (c) humiliation/fear, (d) childhood sexual abuse involving photography, (e) familiarity with the perpetrator, (f) physical force/rape, and (g) active digital penetration. Correlations among these factors further suggested the existence of two relatively independent second-order factors, one based on the levels of physical intrusiveness and the other composed of the psychological/emotional factors. While arguably the most common measurement of severity, physical intrusiveness had little association with critical factors such as humiliation, fear, and association with the perpetrator. Consequently, physical intrusiveness appears to be an inadequate stand-alone measure of childhood sexual abuse severity. These results are proposed to lay the groundwork for an improved, more comprehensive measure of childhood sexual abuse severity.     

Trauma-informed care training in a child welfare system: Moving it to the front line

The use of trauma-informed practices in the child welfare system is critically important to prevent system-induced trauma and encourage timely assessment, triage and referral for care when indicated. Ultimately, such measures have the potential over time to decrease the risk for mental health problems in children exposed to a trauma. This study evaluates an initiative in Arkansas to train child welfare front-line staff members in trauma-informed care practices. We evaluated the impact of the training on knowledge and use of trauma-informed care practices among three types of child welfare staff (Caseworkers, Program Assistants and Other front-line staff). Results suggest that this training process was highly successful in improving knowledge of trauma-informed care practices, especially among staff with the least formal education and training. We also found a significant increase in staff use of trauma-informed care practices at the three-month follow-up with little difference observed across staff groups. Barriers that may prevent staff from full implementation of training concepts are described and strategies to address barriers are proposed.     

Citizenship Consciousness,Nonbounded Solidarity,and Social Justice

This article analyzes the concepts of bounded and nonbounded solidarity. It first reviews some fundamental propositions from the sociological literature and then looks at Amnesty International's conception of solidarity. A third part discusses solidarity as it applies to social work with groups. The conclusion raises five questions social workers need to address to make social justice a standard part of social group work theory and practice.     

A longitudinal study of domestic water conservation behavior

A 1988 study of a school-linked sample in a metropolitan and a regional urban area established baseline data for knowledge, attitudes, intentions, and behavior with regard to water management and conservation (Murphy, Watson, & Moore, 1991). This paper reports on a 1991 follow-up, utilising both longitudinal and cross-sectional samples of students, teachers and parents, which aimed at identifying changes within the community since the initial study. In addition, the study sought to identify factors influential in change and the extent to which the pattern of relationships between knowledge, attitudes, intentions and behaviors had remained stable over time. The results indicated that there was a move towards greater conservation as measured by the variables studied over the three year period, that media interventions and water costs were perceived as influential in this change, and that reported conserving behavior continued to be better predicted by stated intentions than by knowledge. Little difference in the pattern of intervariable relationships was observed across the time span studied.     

The Salience of Multimodal Sensory Stimulation in Early Development: Implications for the Issue of Ecological Validity

Studies of infant development concerned with the emergence of specific perceptual or cognitive abilities have typically focused on responsiveness in only one sensory modality. Research on infant perception, learning, and memory often attempts to reduce multimodal stimulation to “noise” and to control or omit stimulation from other sensory modalities in experimental designs. This type of unimodal research, although important, may not generalize well to the behavior of infants in the multimodal context of the everyday world. Research from animal and human development is reviewed that documents that significant differences in infants' perceptual skills and abilities can be observed under conditions of unimodal versus multimodal stimulation. These studies provide converging evidence for a functional distinction between unimodal and multimodal stimulation during early development and suggest that ecological validity can be enhanced when research findings are generalized appropriately to the natural environment and are not overgeneralized across stimulus properties, tasks, or contexts.     

Landscapes: The Social Construction of Nature and the Environment

Abstract A theoretical framework is provided to understand a cultural group's definition of and relationship with nature and the environment. The framework draws on a social constructionist perspective that includes aspects of phenomenology and symbolic interactionism to define “landscape” as the symbolic environment created by a human act of conferring meaning on nature and the environment. This landscape reflects the selfdefinitions of the people within a particular cultural context. Attention is directed to transformation of the physical environment into landscapes that reflect people's definitions of themselves and on how these landscapes are reconstructed in response to people's changing definitions of themselves. Case studies from sociology and anthropology illustrate the social construction of nature and the environment. A discussion of the applied implications of the theoretical framework in social impact assessment and the global implications in the shifting power struggle over competing landscapes concludes the paper.