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81.
82.
Benzene is one of the best studied of the known human carcinogens. It causes leukemia in humans and a variety of solid tumors in rats and mice. Decades of research on benzene metabolism, pharmacokinetics, cytotoxicity, genotoxicity, and carcinogenicity in vivo and in vitro are starting to converge on a small set of overlapping hypotheses about the most probable biological mechanisms of benzene toxicity and carcinogenicity. Although there is still room for surprises, it seems likely that the ultimate answer to the mystery of how benzene exerts its multiple effects will consist of elaborations and extensions of one or more of the current hypotheses. This paper reviews benzene health effects and biology, showing how various aspects of metabolism and cytotoxicity fit together with genotoxic and nongenotoxic effects to help explain how benzene may cause cancer. Its goals are: (i) to introduce the qualitative biological background needed for detailed quantitative dose-response modeling of benzene cancer risks; and (ii) to survey a rapidly evolving area of research that shows promise of producing fundamental insights into the mechanisms of toxicity and carcinogenesis for several chemicals--benzene and perhaps phenols, catechols, and other hydroxylated ring hydrocarbons--in the decade ahead. 相似文献
83.
Stability in Center Day Care: Relations with Children's Well‐being and Problem Behavior in Day Care1
J. Clasien de Schipper Marinus H. Van IJzendoorn Louis W. C. Tavecchio 《Social Development》2004,13(4):531-550
Mothers and primary professional caregivers of 186 children, aged 6–30 months, participated in this study in which a new measure for daily stability in center day care was developed, describing staffing, grouping, and program features. Relative contributions of infants’ daily experiences of care stability, quality of care, and mother's daily stress to the child's adjustment to day care were analyzed with hierarchical regressions. The child's adjustment was assessed with the Child Behavior Checklist ( Achenbach, 1997 ) and with the Leiden Inventory for the Child's Well‐being in Day Care. Children enrolled in fewer care arrangements showed less internalizing behavior and more well‐being in the day care setting. Children had higher well‐being scores when trusted caregivers were more available. Mother's family management stress was related to more internalizing problem behavior. Interactions between mother's daily stress and stability in care were found to affect the child's adjustment to day care. 相似文献
84.
85.
One of the challenges of introducing greater biological realism into stochastic models of cancer induction is to find a way to represent the homeostatic control of the normal cell population over its own size without complicating the analysis too much to obtain useful results. Current two-stage models of carcinogenesis typically ignore homeostatic control. Instead, a deterministic growth path is specified for the population of "normal" cells, while the population of "initiated" cells is assumed to grow randomly according to a birth-death process with random immigrations from the normal population. This paper introduces a simple model of homeostatically controlled cell division for mature tissues, in which the size of the nonmalignant population remains essentially constant over time. Growth of the nonmalignant cell population (normal and initiated cells) is restricted by allowing cells to divide only to fill the "openings" left by cells that die or differentiate, thus maintaining the constant size of the nonmalignant cell population. The fundamental technical insight from this model is that random walks, rather than birth-and-death processes, are the appropriate stochastic processes for describing the kinetics of the initiated cell population. Qualitative and analytic results are presented, drawn from the mathematical theories of random walks and diffusion processes, that describe the probability of spontaneous extinction and the size distribution of surviving initiated populations when the death/differentiation rates of normal and initiated cells are known. The constraint that the nonmalignant population size must remain approximately constant leads to much simpler analytic formulas and approximations, flowing directly from random walk theory, than in previous birth-death models.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
86.
87.
Louis Henry 《Population studies》2013,67(3)
At the present time there are very few populations, whose members do not practise contraception at all, or only to a very limited extent, and for whom accurate data on nuptiality and fertility exist. Among populations of European residence or origin, there are only a few groups who reject any limitation of families for religious reasons. One of these, the Hutterites, has already been studied; the other, the Old Order Amish, is studied in Ericksen's papers, and my preceding remarks point to the importance of this study. 相似文献
88.
Louis Kontos 《The American Sociologist》2001,32(1):100-106
The following paper examines the cybernetics trajectory of Parsons’ later work and its extension in the work of Luhmann. While
the earlier work was focused on social action as a basic unit of sociological analysis, in The Social System Parsons articulates
a notion of systems as self-generating and self-regulating. In Luhmann’s Social Systems this trajectory is made more explicit
and developed in opposition to the early Parsons. Its metaphorical dimensions are also developed, creating additional levels
and layers of abstraction. Those developments are deemed necessary in order to come to terms with the increasingly “complex”
nature of modern society; however they are problematic in several respects—including their tautological nature which provides
a basis for the unrestrained explanatory power of “system.“ 相似文献
89.
90.
A field study of a tool manufacturing organization examined the impact of supervisory listening indicators on subordinate perceptions of support, trust, and intrinsic motivation and on subordinate performance (productivity and absenteeism). The moderating impact of organizational structure was also investigated. The results indicated that the impact of supervisory listening indicators was very different dependent upon whether the structure of the organizational work group was more mechanistic or more organic. Within the more organic portions of the organization, supportive listening indicators were positively related to production and negatively related to absenteeism. The opposite occurred within the mechanistic levels. At all levels, perceived listening increased supportiveness, trust, and intrinsic motivation, although listening for accuracy had the strongest impact. 相似文献