被神经性毒剂染毒的蛋白IgG中有机磷加合物的研究

本文对IgG与神经性毒剂的加合物进行了研究。用过量的神经性毒剂(沙林、梭曼、VX、环沙林)对IgG(人、大鼠IgG)进行体外染毒,用胰蛋白酶进行酶解,所得样品用Q Exactive LC-MS/MS方法进行分析鉴定,发现了IgG与神经性毒剂的加合物肽段。其中,从人的IgG中发现了4个被标记的肽段,从大鼠的IgG中发现了1个被标记的肽段,另外,还从肽段的二级谱图中发现了酪氨酸加合物的特征离子碎片。本文首次发现了被神经性毒剂标记的IgG肽段,进而说明IgG是鉴定神经性毒剂中毒的一类重要的标记蛋白。     

Diffusion Indexes With Sparse Loadings

The use of large-dimensional factor models in forecasting has received much attention in the literature with the consensus being that improvements on forecasts can be achieved when comparing with standard models. However, recent contributions in the literature have demonstrated that care needs to be taken when choosing which variables to include in the model. A number of different approaches to determining these variables have been put forward. These are, however, often based on ad hoc procedures or abandon the underlying theoretical factor model. In this article, we will take a different approach to the problem by using the least absolute shrinkage and selection operator (LASSO) as a variable selection method to choose between the possible variables and thus obtain sparse loadings from which factors or diffusion indexes can be formed. This allows us to build a more parsimonious factor model that is better suited for forecasting compared to the traditional principal components (PC) approach. We provide an asymptotic analysis of the estimator and illustrate its merits empirically in a forecasting experiment based on U.S. macroeconomic data. Overall we find that compared to PC we obtain improvements in forecasting accuracy and thus find it to be an important alternative to PC. Supplementary materials for this article are available online.     

Complete moment convergence and Lr convergence for asymptotically almost negatively associated random variables

In this paper, we investigate the complete moment convergence and L_r convergence for maximal partial sums of asymptotically almost negatively associated random variables under some general conditions. The results obtained in the paper generalize some corresponding ones for negatively associated random variables.     

城市经济圈发展助推区域一体化——兼论南沙新区与港澳的经济合作

根据区域一体化理论,结合新时期广东省在推进珠三角一体化中,建立和发展广佛肇、深莞惠和珠中江三个经济圈的实践,分析了区域经济一体化对区域整体发展的新意义、地位和作用,讨论了珠江三角洲通过建设和发展若干个以经济发展为核心的现代都市圈,对于新时期加强与港澳经济合作,促进区域经济一体化的更好发展颇具深远的意义和作用。     

Senior centres in the lives of older Americans: implications for Chinese older adults

As a critical community resource, the senior centre has provided older Americans with a wide array of recreational, nutritional, health, and social service programmes. Funding resources include the Older Americans Act allocations, local organisations and governments, national charities, voluntary associations, and religious associations. The types of programmes offered at a senior centre reflect two models: social agency model or voluntary organisation model. The five most popular programmes are nutrition, health and fitness, recreation, volunteering, and social services. Participation in senior centre activities has positive impacts on the overall well-being of older adult participants. With the rapid growth in the ageing population and improved life expectancy in China, senior centres may serve as a focal point for Chinese older adults by providing a broad spectrum of social services to enhance the well-being of community-dwelling older adults, to support their independence and dignity, and to facilitate ageing in place in later life.     

基于分权视角的城市规划管理体制模式及改革建议

关于我国的城市规划管理权限一直存在＂集中＂与＂放权＂的讨论,并且城市规划管理体制也存在差异。通过对全国部分城市的规划管理体制进行梳理,从市、区（县、市）两级分权视角总结出我国城市规划管理体制中的＂垂直型＂、＂半垂直型＂和＂非垂直型＂三种典型模式,分别以南京、北京和上海为案例分析三种规划管理体制典型模式的主要特点和事权划分,并对其各自的优缺点进行比较,最后提出我国城市规划管理体制改革的若干建议,包括将规划决策权＂上收＂与实施管理重心＂下移＂、建立＂市—区—镇（街）＂三级规划管理机构体系、整合市区两级规划部门内部机构设置形成＂大处室＂和＂大科室＂以及完善城市规划委员会制度等。     

解析《野性的呼唤》中的自然主义

杰克.伦敦是美国自然主义作家中的杰出代表,他的作品《野性的呼唤》则充分体现了战胜敌人后而存活所需的力量与勇气,表达了适者生存的原则。而巴克传奇经历及其主题思想的揭示对当今中国不能不说有其特定的社会教育意义。     

金融危机以来美国贸易逆差的调整目标区间考察

2008年金融危机以来,美国长期巨额贸易逆差调整广受关注,此问题涉及到调整目标和调整成效的讨论.美国贸易逆差调整的目标主要包括四个方面:一是把控国际贸易秩序的话语权;二是推进再工业化,抢占新一轮产业革命的制高点;三是保持经济相对稳定增长、相对充分的就业与低通胀;四是继续维持美元霸权地位.金融危机后的再工业化战略实施及美国贸易政策的调整使得美国商品贸易逆差幅度缩小,目标逐步趋近,预计以美国贸易逆差占GDP的比重来衡量的调整目标将在一定区间内继续波动,但较21世纪以来的近二十年收窄.而COVID-19疫情的冲击将使美国贸易逆差的调整目标开始偏向经济复苏与经济增长.     

首都第二机场建设与航空人才需求调研

首都第二机场的建设已成定局,由此而引起的大量人才需求是各层次学校所关注的焦点。北京经济管理职业学院是否能抓住这一得天独厚的机遇,将是未来几年对北京经济管理职业学院的考验,因此根据近几年来对首都二机场建设的资料的收集和调研,了解了机场建设对航空人才的需求,为学院的发展提供了建设性的参考性意见。