Risk Assessment of Human Listeriosis from Semisoft Cheeses Made from Raw Sheep's Milk in Lazio and Tuscany (Italy)

Semisoft cheese made from raw sheep's milk is traditionally and economically important in southern Europe. However, raw milk cheese is also a known vehicle of human listeriosis and contamination of sheep cheese with Listeria monocytogenes has been reported. In the present study, we have developed and applied a quantitative risk assessment model, based on available evidence and challenge testing, to estimate risk of invasive listeriosis due to consumption of an artisanal sheep cheese made with raw milk collected from a single flock in central Italy. In the model, contamination of milk may originate from the farm environment or from mastitic animals, with potential growth of the pathogen in bulk milk and during cheese ripening. Based on the 48‐day challenge test of a local semisoft raw sheep's milk cheese we found limited growth only during the initial phase of ripening (24 hours) and no growth or limited decline during the following ripening period. In our simulation, in the baseline scenario, 2.2% of cheese servings are estimated to have at least 1 colony forming unit (CFU) per gram. Of these, 15.1% would be above the current E.U. limit of 100 CFU/g (5.2% would exceed 1,000 CFU/g). Risk of invasive listeriosis per random serving is estimated in the 10^?12 range (mean) for healthy adults, and in the 10^?10 range (mean) for vulnerable populations. When small flocks (10–36 animals) are combined with the presence of a sheep with undetected subclinical mastitis, risk of listeriosis increases and such flocks may represent a public health risk.     

Legitimacy theory may explain the failure of global adoption of IFRS: the case of Europe and the U.S.

We investigate the reasons why “adoption” of one set of globally accepted accounting standards is presently unachievable. By “adoption” we mean that a jurisdiction incorporates IFRS instantly as its national accounting as issued by the IASB. We state that the IASB has used a Legitimacy Theory strategy to gain acceptance of its standards by more than 120 countries across the globe but it has only gained pseudo-“adoption” (not as published by the IASB) of its standards by many countries. We contend that achieving policing and enforcement of its standards globally has proven to be empirically illusive. This legitimacy deficit may explain why convergence between the IASB and FASB is currently idle. We offer a possible solution to bridging the legitimacy gap of global adoption of IFRS. We propose an internationally respected regulator and suggest the IOSCO for this role through its participation in the IFRS Foundation Monitoring Board for policing and enforcement of IFRS for cross-listed firms reporting in compliance with IFRS so that the IASB’s output legitimacy may be achieved globally.     

Increased risk of emergency department presentations for bronchiolitis in infants exposed to air pollution

Air pollution has been linked to an increased risk of several respiratory diseases in children, especially respiratory tract infections. The present study aims to evaluate the association between pediatric emergency department (PED) presentations for bronchiolitis and air pollution. PED presentations due to bronchiolitis in children aged less than 1 year were retrospectively collected from 2007 to 2018 in Padova, Italy, together with daily environmental data. A conditional logistic regression based on a time-stratified case-crossover design was performed to evaluate the association between PED presentations and exposure to NO₂, PM2.5, and PM10. Models were adjusted for temperature, relative humidity, atmospheric pressure, and public holidays. Delayed effects in time were evaluated using distributed lag non-linear models. Odds ratio for lagged exposure from 0 to 14 days were obtained. Overall, 2251 children presented to the PED for bronchiolitis. Infants’ exposure to higher concentrations of PM10 and PM2.5 in the 5 days before the presentation to the PED increased the risk of accessing the PED by more than 10%, whereas high concentrations of NO₂ between 2 and 12 days before the PED presentation were associated with an increased risk of up to 30%. The association between pollutants and infants who required hospitalization was even greater. A cumulative effect of NO₂ among the 2 weeks preceding the presentation was also observed. In summary, PM and NO₂ concentrations are associated with PED presentations and hospitalizations for bronchiolitis. Exposure of infants to air pollution could damage the respiratory tract mucosa, facilitating viral infections and exacerbating symptoms.     

Framing socioecological complexity: The long-term evolution of multiple dimensions of desertification risk in Italy

Desertification risk depends on the interplay of biophysical and socioeconomic drivers, among which climate change, soil depletion, landscape modifications, and biodiversity decline are key factors of change in Southern Europe. The present study introduces a diachronic analysis of desertification risk in Italy adopting a multidimensional approach based on four dimensions (ecological, economic, demographic, and administrative) assessed at three dates (1961, 1991, and 2011). These risk components were evaluated separately in Southern Italy, a formerly affected region (sensu United Nations Convention to Combat Desertification), and Northern/Central Italy, a nonaffected region in the country. All risk measures document how the divide between affected and nonaffected regions in Italy has gradually reduced. Because of local warming and rising human pressure, Northern Italy has recently displayed a level of desertification risk close to those observed in Southern Italy over the last 30 years. These results suggest a thorough revision of the national classification of risky areas, that may inform more specific mitigation and adaptation policies responding effectively to recent socioenvironmental trends and local (economic) dynamics. The intrinsic system's evolution observed at both regional and national level in Italy may be generalized to a broader European context. Our work finally documents the appropriateness of a multidimensional definition of desertification risk grounded on the joint analysis of ecological, demographic, economic, and administrative indicators. A comprehensive knowledge of socioeconomic patterns and processes of change contributes to more precise scenario modeling and design of integrated strategies mitigating desertification risk.     

Coming Out and Job Satisfaction: A Moderated Mediation Model

Prior research suggests that the disclosure of sexual identity at work is not always significantly associated with job satisfaction. The authors investigated (a) the mediating role of workplace heterosexist climate in linking workplace outness with job satisfaction, and (b) the moderating role of anticipated discrimination in influencing the indirect and direct relationship between workplace outness and job satisfaction. This model was tested among 1,460 lesbian, gay, and bisexual (LGB) employees in Italy. Results indicated that workplace heterosexist climate mediated relationships between workplace outness and job satisfaction. Anticipated discrimination moderated the relationships between LGB employees’ disclosure of their sexual identity and job satisfaction and between workplace heterosexist climate and job satisfaction. This moderated mediation model may assist researchers who aim to understand the complexity of the relationship between workplace outness and job satisfaction. In this regard, practitioners need to recognize the role played by workplace heterosexist climate and anticipated discrimination.     

Modified quasi-profile likelihoods from estimating functions

We discuss higher-order adjustments for a quasi-profile likelihood for a scalar parameter of interest, in order to alleviate some of the problems inherent to the presence of nuisance parameters, such as bias and inconsistency. Indeed, quasi-profile score functions for the parameter of interest have bias of order O(1)$\mathrm{O}(1)$, and such bias can lead to poor inference on the parameter of interest. The higher-order adjustments are obtained so that the adjusted quasi-profile score estimating function is unbiased and its variance is the negative expected derivative matrix of the adjusted profile estimating equation. The modified quasi-profile likelihood is then obtained as the integral of the adjusted profile estimating function. We discuss two methods for the computation of the modified quasi-profile likelihoods: a bootstrap simulation method and a first-order asymptotic expression, which can be simplified under an orthogonality assumption. Examples in the context of generalized linear models and of robust inference are provided, showing that the use of a modified quasi-profile likelihood ratio statistic may lead to coverage probabilities more accurate than those pertaining to first-order Wald-type confidence intervals.     

Chain graph models: topological sorting of meta-arrows and efficient construction of $${\mathcal{B}}$$ -essential graphs

Essential graphs and largest chain graphs are well-established graphical representations of equivalence classes of directed acyclic graphs and chain graphs respectively, especially useful in the context of model selection. Recently, the notion of a labelled block ordering of vertices was introduced as a flexible tool for specifying subfamilies of chain graphs. In particular, both the family of directed acyclic graphs and the family of “unconstrained” chain graphs can be specified in this way, for the appropriate choice of . The family of chain graphs identified by a labelled block ordering of vertices is partitioned into equivalence classes each represented by means of a -essential graph. In this paper, we introduce a topological ordering of meta-arrows and use this concept to devise an efficient procedure for the construction of -essential graphs. In this way we also provide an efficient procedure for the construction of both largest chain graphs and essential graphs. The key feature of the proposed procedure is that every meta-arrow needs to be processed only once.     

An individual treatment programme for sexually abused adult males: description and preliminary findings

Growing recognition of male sexual abuse and its potentially debilitating effects has underscored the need to develop effective treatment interventions for this population. The present study describes an individual treatment programme that was developed for adult males who have experienced childhood sexual abuse. The treatment programme focused on three areas related to sexual abuse, specifically feelings of self‐blame, anger and anxiety. The study also presents preliminary findings on treatment effects, using self‐report measures that five participants completed prior to treatment and at various assessments following treatment termination. Overall findings indicated improvements in behavioural self‐blame, anger, state anxiety and trait anxiety. Treatment did not appear to have an effect on characterological self‐blame over the long term. The study's findings are limited by the reliance on self‐report data and the absence of a comparison group. As such, our findings should be viewed as an initial contribution to the currently limited empirical data on treatment effects for sexually abused adult males. Copyright © 2005 John Wiley & Sons, Ltd.     

Threshold‐free estimation of functional antibody titers of a group B streptococcus opsonophagocytic killing assay

Opsonophagocytic killing assays (OPKA) are routinely used for the quantification of bactericidal antibodies in blood serum samples. Quantification of the OPKA readout, the titer, provides the basis for the statistical analysis of vaccine clinical trials having functional immune response endpoints. Traditional OPKA titers are defined as the maximum serum dilution yielding a predefined bacterial killing threshold value, and they are estimated by fitting a dose‐response model to the dilution‐killing curve. This paper illustrates a novel definition of titer, the threshold‐free titer, which preserves biological interpretability while not depending on any killing threshold or on a postulated shape of the dose‐response curve. These titers are shown to be more precise than the traditional threshold‐based titers when using simulated and experimental group B streptococcus OPKA experimental data. Also, titer linearity is shown to be not measurable when using threshold‐based titers, whereas it becomes measurable using threshold‐free titers. The biological interpretability and operational characteristics demonstrated here indicate that threshold‐free titers are an appropriate tool for the routine analysis of OPKA data. Copyright © 2015 John Wiley & Sons, Ltd.     

Spouses’ earnings association and inequality: A non-linear perspective

We analyze the association between spouses’ earnings taking account of non-linearities along both spouses’ distribution of earnings. We also document the non-linearity of the relationships between earnings and labor force participation, earnings and couple formation, and earnings and number of children. Using simulations, we then analyze how changes in spouses’ rank-dependence structure, labor force participation and couple formation contribute to the upsurge in inequality in the U.S between 1967 and 2018. We find that an increased tendency towards positive sorting contributed substantially to the rise in inequality only among dual-earner couples, while it contributed little to overall inequality across households. Temporal and distributional heterogeneity are important, as earnings association had a more substantial role in the bottom of the earnings distribution and in recent years. The decline in couple formation contributed substantially to the rise in inequality, while the increase in female labor force participation and the fertility decline had equalizing effects.