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61.
Lesbian, gay, and bisexual (LGB) youths are over-represented in the homeless population. To examine why some LGB youths become homeless, this report compares homeless and non-homeless LGB youths. Of the 156 LGB youths, 48% reported ever being homeless (i.e., running away or being evicted from home). Results indicate that sexual orientation awareness and the initiation of sexual behavior occurred earlier in homeless than in non-homeless LGB youths and predated the first homeless episode. Substance use was more frequent and first occurred at an earlier age in homeless as compared to non-homeless LGB youths; however, substance use occurred subsequent to first homelessness. Childhood sexual abuse was associated with homelessness; and, early sexual orientation development was related to homelessness among youths without a history of sexual abuse. Findings suggest that interventions should help youths cope with their unfolding sexual orientation and work to prevent or address the consequences of sexual abuse. 相似文献
62.
This paper explores the current status of professionalization of communication management practice which emerged from a content analysis of 360 responses to questions exploring the nature of practitioner identity (or dis-identity) with communication management. The results revealed that positive identification arose from an ability to influence, emulate the professional values of peers, and cohesion with the wider practitioner community. Conversely, dis-identification arose from the poor performance of colleagues, advice not being taken, and media ‘spin’. 相似文献
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This analysis of International Business (IB) corruption literature identifies gaps and inconsistencies in how corruption is perceived or deliberated in top academic journals. The reviewed articles tend to focus on one of the three key themes of IB corruption (Contributing factors, Consequences, and Combating) and are categorised into the six sub-domains of the IB framework. The content of the articles is categorised into the respective themes and discussed in relation to underpinning theories and key constructs. The process is intended to be less a synthesis of the literature than an audit revealing that IB corruption research is weakened by tendencies to: 1) Be siloed within its subtheme and to not cross-tie to work in other key themes—this issue is very severe in the Combating theme; 2) Have a short-term focus that disregards the cumulative effects of total graft, and; 3) Asymmetrically focus (predominantly) on the supply side of corruption. These finding suggest several avenues for further research. 相似文献
65.
Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation
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Margaret Gamalo‐Siebers Jasmina Savic Cynthia Basu Xin Zhao Mathangi Gopalakrishnan Aijun Gao Guochen Song Simin Baygani Laura Thompson H. Amy Xia Karen Price Ram Tiwari Bradley P. Carlin 《Pharmaceutical statistics》2017,16(4):232-249
Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics. 相似文献
66.
In quantitative trait linkage studies using experimental crosses, the conventional normal location-shift model or other parameterizations may be unnecessarily restrictive. We generalize the mapping problem to a genuine nonparametric setup and provide a robust estimation procedure for the situation where the underlying phenotype distributions are completely unspecified. Classical Wilcoxon–Mann–Whitney statistics are employed for point and interval estimation of QTL positions and effects. 相似文献
67.
Margaret Ann Hagerman 《Journal of marriage and the family》2017,79(1):60-74
For the past 30 years, the definition of racial socialization has referred to how parents prepare children of color to flourish within a society structured by white supremacy. Drawing on ethnographic interviews with eight white affluent fathers, this study explores fathers' participation in white racial socialization processes. The article focuses on fathers who identify as “progressive” and examines the relationship between fathers' understandings of what it means to raise an “antiracist” child, the explicit and implicit lessons of racial socialization that follow from these understandings, and hegemonic whiteness. Findings illustrate how these fathers understand their role as a white father, how their attempts to raise antiracist children both challenge and reinforce hegemonic whiteness, and what role race and class privilege play in this process. 相似文献
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This paper examines the decline in non-numeric responses to questions about fertility preferences among women in the developing world. These types of response—such as ‘don’t know’ or ‘it’s up to God’—have often been interpreted through the lens of fertility transition theory as an indication that reproduction has not yet entered women’s ‘calculus of conscious choice’. However, this has yet to be investigated cross-nationally and over time. Using 19?years of data from 32 countries, we find that non-numeric fertility preferences decline most substantially in the early stages of a country’s fertility transition. Using country-specific and multilevel models, we explore the individual- and contextual-level characteristics associated with women’s likelihood of providing a non-numeric response to questions about their fertility preferences. Non-numeric fertility preferences are influenced by a host of social factors, with educational attainment and knowledge of contraception being the most robust and consistent predictors. 相似文献
70.
Corey E. Flanders Lesley A. Tarasoff Melissa Marie Legge Margaret Robinson Giselle Gos 《Journal of homosexuality》2017,64(8):1014-1032
The majority of LGBTQ psychological research focuses on dysfunction. The exclusion of strengths-based perspectives in LGBTQ psychology limits the understanding of LGBTQ mental health. In this article we report experiences that young bisexual and other nonmonosexual people perceive as affirming of their sexual identity. A 28-day, daily diary study was used to investigate whether bisexual-identified participants encountered positive experiences related to their sexual identity, and which type of experiences they perceived to be positive. Using a constructivist grounded theory approach, participants’ experiences were organized according to a social ecological model. Experiences were reported at the intrapersonal, interpersonal, and institutional levels, but most positive sexual identity experiences occurred at the interpersonal level. Implications for positive health outcome research and the integration of positive psychology with LGBTQ psychology are discussed, as well as study limitations. 相似文献