Assessing accuracy of a continuous screening test in the presence of verification bias

Summary.  In studies to assess the accuracy of a screening test, often definitive disease assessment is too invasive or expensive to be ascertained on all the study subjects. Although it may be more ethical or cost effective to ascertain the true disease status with a higher rate in study subjects where the screening test or additional information is suggestive of disease, estimates of accuracy can be biased in a study with such a design. This bias is known as verification bias. Verification bias correction methods that accommodate screening tests with binary or ordinal responses have been developed; however, no verification bias correction methods exist for tests with continuous results. We propose and compare imputation and reweighting bias-corrected estimators of true and false positive rates, receiver operating characteristic curves and area under the receiver operating characteristic curve for continuous tests. Distribution theory and simulation studies are used to compare the proposed estimators with respect to bias, relative efficiency and robustness to model misspecification. The bias correction estimators proposed are applied to data from a study of screening tests for neonatal hearing loss.     

解码理论在日语听力理解中的运用

在日语学习中,因受语言环境和学习方法的限制,听力被认为是提高日语水平和成绩的一大难关。作者遵循听觉系统中听力的解码理论,以一年一度的国际日本语能力测试题为例,提出并具体分析了提高日语听力的三种模式———预测法、捕捉法和贯穿法,并指出运用这些技巧时应注意的几个问题。期望学习者能克服心理障碍,讲究科学的方法,把这些模式积极运用到平时的训练和测试中去,以此来提高日语听力水平和成绩。     

Evaluating DISCOVER's Effectiveness in Enhancing College Students' Social Cognitive Career Development

College students (20 women, 14 men) seeking career counseling services at a university career center participated in this exploratory investigation. A 2 (DISCOVER treatment) × 2 (counseling treatment) research design was used to evaluate the individual and combined effects of DISCOVER (ACT, 1998) and counseling on participants' career decision‐making self‐efficacy and career decision‐making attributional style. Findings revealed a significant effect of the use of DISCOVER on participants' career decision‐making self‐efficacy and their sense of control over the career decision‐making process. Results are discussed regarding the implications for career counseling and ideas for further research in this domain.     

Residual analysis for spatial point processes (with discussion)

Summary.  We define residuals for point process models fitted to spatial point pattern data, and we propose diagnostic plots based on them. The residuals apply to any point process model that has a conditional intensity; the model may exhibit spatial heterogeneity, interpoint interaction and dependence on spatial covariates. Some existing ad hoc methods for model checking (quadrat counts, scan statistic, kernel smoothed intensity and Berman's diagnostic) are recovered as special cases. Diagnostic tools are developed systematically, by using an analogy between our spatial residuals and the usual residuals for (non-spatial) generalized linear models. The conditional intensity λ plays the role of the mean response. This makes it possible to adapt existing knowledge about model validation for generalized linear models to the spatial point process context, giving recommendations for diagnostic plots. A plot of smoothed residuals against spatial location, or against a spatial covariate, is effective in diagnosing spatial trend or co-variate effects. Q – Q -plots of the residuals are effective in diagnosing interpoint interaction.     

Benchmark Analysis: Shopping with Proper Confidence

We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data.     

Improving performance? The adoption and implementation of quality systems in U.K. nonprofits

There are increasing and multiple pressures on nonprofit organizations to demonstrate excellence in performance. Although there is a growing literature on the various approaches to performance improvement taken by nonprofits, little is known about the processes involved in the adoption and implementation of specific approaches. This article is about the adoption and use of one approach to performance improvement, “quality systems,” in the U.K. nonprofit sector. We report findings about factors that encourage nonprofits to adopt quality systems. We also analyze the distinctive challenges of implementing quality approaches in a nonprofit sector context and suggest critical success factors. The article concludes with a discussion of the organizational and policy implications of applying the management concepts of quality and performance to the nonprofit sector.     

解决我国农业剩余劳动力就业问题的思路

农业剩余劳动力的就业问题 ,是我国经济中的一个重要问题。要解决好这一问题 ,就需要制定引导农业劳动力转移的战略 ,多方寻求劳动力转移的途径 ,努力提高农业劳动力素质 ,建立健全劳动力市场 ,营造有利于农业剩余劳动力就业的制度环境 ,控制人口过快增长     

Stress at work and psychological and immunological parameters in a group of Norwegian female bank employees

This study concerned the immunological correlates of stress and work. Self reported stress, emotional state, ego-strength, and defensiveness were examined in relation to measures of cellular immunity (T-cell response to Con A and number of T4 and T8 cells) and humoral immunity (concentrations of immunoglobulins and complement components in plasma) in a group of 96 Norwegian female bank employees. The analyses showed that workload, the stress factor with the highest group mean, was associated with number of T-cells, while strain due to body posture during work was related to concentrations of IgM and C3. Further, depression was significantly correlated with IgM concentration and T-cell number, and anxiety with C3 concentration. T-cell activity was the immunological parameter most consistently associated with psychological well-being, showing positive correlations with defensiveness and ego-strength and negative correlations with anxiety and depression. In conclusion, T-cell number and concentrations of IgM and C3 were sensitive to both work-related stress experience and emotional distress. Coping abilities, indicated by the MMPI Ego-strength scale and emotional distress, were reflected in T-cell activity; insufficient coping was associated with low T-cell activity.     

林业发展阶段研究概述

阶段性是事物发展必须遵循的一个客观规律,林业的发展同样也具有阶段性.只有充分认识各个时期林业发展所处的历史阶段和相应特征,才能更好地制定政策和发展战略.该文将以往的林业方面的阶段性研究加以综述,以期获得收益和启发,并为以后的研究打下基础.