Longitudinal Relations Among Parental Emotional Expressivity and Sympathy and Prosocial Behavior in Adolescence

Concurrent and longitudinal relations among parental emotional expressivity, children's sympathy and children's prosocial behavior were assessed with correlations and structural equation modeling when the children were 55–97 months old (N = 214; M age = 73 months, SD = 9.59) and eight years later (N = 130; ages 150–195 months old, M = 171 months, SD = 10.01). Parent emotional expressivity (positive and negative) and children's sympathy were stable across time and early parent‐reported sympathy predicted adolescents' sympathy and prosocial behavior. Parents' positive expressivity was positively related to sympathy and prosocial behavior, but in adolescence, this was likely primarily because of consistency over time. Early observed parental negative expressivity was negatively related to adolescents' prosocial behavior. Reported negative expressivity in childhood was negatively related to boys' sympathy in childhood and positively related to girls' sympathy behavior in adolescence. The later relation remained significant when controlling for the stability of parental expressivity and sympathy, suggesting an emerging positive relation between the variables for girls.     

Single-cell antisense RNA amplification and microarray analysis as a tool for studying neurological degeneration and restoration

Neurodegenerative diseases typically affect subpopulations of neurons. Characterizing these vulnerable cells and identifying the factors that make them susceptible to damage while neighboring cells remain resistant are essential to the understanding of molecular pathogenesis that underlies neurodegenerative diseases. Classically, molecular analysis of the central nervous system involves the identification and isolation of an anatomic region of interest; next, the relevant tissue is pulverized, and the resulting homogenate is analyzed. Although this method provides useful data, its effectiveness diminishes when used in areas of high cellular diversity or in instances in which one cell type is lost as a consequence of selective cell death or quiescence. A technique that affords the ability to assess molecular events in a very precise anatomical site would provide a powerful tool for this research discipline. In this review, we discuss the amplification of messenger RNA from single neural cells and the subsequent use of the RNA to probe DNA microarrays in an effort to create cell-specific molecular profiles. Specifically, recent work in single-cell expression profiling in Alzheimer's and Huntington's diseases is discussed. We also review some new work with neural stem cells and their application to restorative neurobiology. Finally, we discuss the use of cell-specific molecular profiles to better understand the basics of neuronal cell biology.     

The implications of adoption for donor offspring following donor-assisted conception

In this paper the authors, all experienced social workers with research and practice interests in assisted conception, review practices concerning access to genetic origins information in adoption, and consider to what extent these may be relevant for practice in donor‐assisted conception. The paper concludes with policy and practice recommendations that take account of the views of donor offspring and their desire for increased information about their genetic heritage.     

Distinctive features of age-specific fertility profiles in the English-speaking world: common patterns in Australia,Canada, New Zealand and the United States, 1970-98

The paper seeks to identify common features in the fertility patterns of the English-speaking world and provide a model basis for comparison of fertility between countries and over time. Attention is focused on the heterogeneity within the fertility patterns of Australia, Canada, New Zealand, and the United States, similar to that reported earlier for the UK and the Irish Republic. The recent age-specific fertility patterns of these countries display a marked 'bulge' in fertility of women under age 25. A mixture model with two-component Hadwiger functions provides a suitable fit. The heterogeneity thus suggested is related to the proportion of births outside marriage. Additionally, there is some evidence that, in the United States, and lesser extent in New Zealand, this heterogeneity in fertility patterns may be explained by ethnic difference in the timing and number of births.