Early experiences of mentoring: Design and use of multimedia materials for teaching OR/MS

The MENTOR project, based at the University of Strathclyde, is producing multimedia computer based learning materials with the aim of improving both the effectiveness and the efficiency of teaching Operational Research/Management Science in higher education. The process of development has been carefully designed to encourage ownership of and commitment to the materials amongst lecturing staff in Universities, with the aim of ensuring widespread use. The paper outlines this process of development and design of materials. Experiences in introducing students to the use of these materials as an integrated part of a Management Science class are reported. Feedback from students has been very positive but also indicates the need for ongoing support and direction.     

Openness in adoption: Challenging the narrative of historical progress

One significant change in adoption practice that has occurred over the last four decades is the shift away from an expectation of confidentiality towards an expectation of openness in adoption. Openness is typically conceived in terms of the level of contact between adoptive and birth families following adoption or the extent to which adoption is openly discussed within the adoptive family. While these shifts in practice have generated controversy, they are largely supported by research evidence and have become a feature of contemporary adoptive family life. As a result, the narrative that has emerged in relation to openness in adoption is one of historical progress. In this paper, I argue that the lived reality of adoption is less straightforward than this narrative suggests. An analysis of the social and cultural context in which adoption operates suggests instead that the persistent feature of adoption throughout this historical period of increasing openness can be more accurately described as a state of enduring ambiguity regarding the nature of post‐adoption relationships. The paper highlights the potentially damaging consequences of overlooking this aspect of adoptive family life and comments on the role of policy in shaping openness in adoption.     

Who killed change management?

A story is told here of an investigation into change management's apparent death, provoked by the dubious business novel Who Killed Change [Blanchard, K., J. Britt, P. Zigarmi, and J. Hoekstra. 2009. Who Killed Change? Solving the Mystery of Leading People Through Change. London: Harper Collins Publishers]. The story is told over eight chapters inviting you to investigate competing explanations for the death of change management using the structure of the story arc: stasis, trigger, quest, surprise, critical choice, climax, reversal and resolution. An annoying voice (sometimes interior monologue and at other times dialogue) of another reader keen to inform and frame your understanding of the status of change management remains ever present. The case is solved with the story's resolution providing insights into advantages of investigating over literature reviewing, the problematic/masculine nature of murder metaphors, the academic potential of story arcs and the mystery which characterises organizational change.     

Bayesian adjustment for unidirectional misclassification in ordinal covariates

In this paper, we study the identification of Bayesian regression models, when an ordinal covariate is subject to unidirectional misclassification. Xia and Gustafson [Bayesian regression models adjusting for unidirectional covariate misclassification. Can J Stat. 2016;44(2):198–218] obtained model identifiability for non-binary regression models, when there is a binary covariate subject to unidirectional misclassification. In the current paper, we establish the moment identifiability of regression models for misclassified ordinal covariates with more than two categories, based on forms of observable moments. Computational studies are conducted that confirm the theoretical results. We apply the method to two datasets, one from the Medical Expenditure Panel Survey (MEPS), and the other from Translational Research Investigating Underlying Disparities in Acute Myocardial infarction Patients Health Status (TRIUMPH).     

Dose‐Response Models Incorporating Aerosol Size Dependency for Francisella tularensis

The effect of bioaerosol size was incorporated into predictive dose‐response models for the effects of inhaled aerosols of Francisella tularensis (the causative agent of tularemia) on rhesus monkeys and guinea pigs with bioaerosol diameters ranging between 1.0 and 24 μm. Aerosol‐size‐dependent models were formulated as modification of the exponential and β‐Poisson dose‐response models and model parameters were estimated using maximum likelihood methods and multiple data sets of quantal dose‐response data for which aerosol sizes of inhaled doses were known. Analysis of F. tularensis dose‐response data was best fit by an exponential dose‐response model with a power function including the particle diameter size substituting for the rate parameter k scaling the applied dose. There were differences in the pathogen's aerosol‐size‐dependence equation and models that better represent the observed dose‐response results than the estimate derived from applying the model developed by the International Commission on Radiological Protection (ICRP, 1994) that relies on differential regional lung deposition for human particle exposure.     

A Comparative Pharmacokinetic Estimate of Mercury in U.S. Infants Following Yearly Exposures to Inactivated Influenza Vaccines Containing Thimerosal

The use of thimerosal preservative in childhood vaccines has been largely eliminated over the past decade in the United States because vaccines have been reformulated in single‐dose vials that do not require preservative. An exception is the inactivated influenza vaccines, which are formulated in both multidose vials requiring preservative and preservative‐free single‐dose vials. As part of an ongoing evaluation by USFDA of the safety of biologics throughout their lifecycle, the infant body burden of mercury following scheduled exposures to thimerosal preservative in inactivated influenza vaccines in the United States was estimated and compared to the infant body burden of mercury following daily exposures to dietary methylmercury at the reference dose established by the USEPA. Body burdens were estimated using kinetic parameters derived from experiments conducted in infant monkeys that were exposed episodically to thimerosal or MeHg at identical doses. We found that the body burden of mercury (AUC) in infants (including low birth weight) over the first 4.5 years of life following yearly exposures to thimerosal was two orders of magnitude lower than that estimated for exposures to the lowest regulatory threshold for MeHg over the same time period. In addition, peak body burdens of mercury following episodic exposures to thimerosal in this worst‐case analysis did not exceed the corresponding safe body burden of mercury from methylmercury at any time, even for low‐birth‐weight infants. Our pharmacokinetic analysis supports the acknowledged safety of thimerosal when used as a preservative at current levels in certain multidose infant vaccines in the United States.     

Longitudinal Links between Adolescent and Peer Conduct Problems and Moderation by a Sensitivity Genetic Index

The most extensively studied influence on adolescent conduct problem behaviors is peers, and the literature points to genetics as one source of individual differences in peer influence. The purpose of this study was to test the hypothesis that an environmental sensitivity genetic index comprised of DRD4, 5‐HTTLPR, and GABRA2 variation would moderate the association between peer and adolescent conduct problems. Latent growth modeling was applied to PROSPER project longitudinal data from adolescents and their peers. Results showed the hypothesis was supported; adolescents with more copies of putative sensitivity alleles were more strongly influenced by their peers. The interaction form was consistent with differential susceptibility in follow‐up analyses. Strengths and weaknesses of genetic aggregates for sensitivity research are discussed.     

The political process of the revolutionary samurai: a comparative reconsideration of Japan’s Meiji Restoration

In the 1860s and 1870s, the feudal monarchy of the Tokugawa shogunate, which had ruled Japan for over two centuries, was overthrown, and the entire political order it had commanded was dismantled. This immense political transformation, comparable in its results to the great social revolutions of the seventeenth through nineteenth centuries in the West, was distinctive for lacking a major role for mass political mobilization. Since popular political action was decisive elsewhere for both providing the force for social revolutions to defeat old regimes and for pushing revolutionary leaders to more radical policies, the Meiji Restoration’s combination of revolutionary outcomes with conservative personnel and means is puzzling. This article argues that previous accounts fail to explain why a group of relatively low-status samurai—administrative functionaries with some hereditary political privileges but in fact little secure power within the old regime—was able to overcome far more deeply entrenched political actors. To explain this, it is necessary to distinguish clearly between two political processes: the long-standing political relations of feudal monarchy and magnate lords and the unprecedented emergence of independent samurai political action and organizations cutting across domain boundaries. It was the interaction of these two processes that produced the overthrow of the Tokugawa and enabled the revolutionary outcomes that followed it. This article’s revised explanation of the Meiji Restoration clearly places it within the same theoretical parameters as the major revolutions of the seventeenth century and later.     

Good Friendships among Children: A Theoretical and Empirical Investigation

Ethical dimensions of friendship have rarely been explicitly addressed as aspects of friendship quality in studies of children's peer relationships. This study identifies aspects of moral virtue significant for friendship, as a basis for empirically investigating the role of ethical qualities in children's friendship assessments and aspirations. We introduce a eudaimonic conception of friendship quality, identify aspects of moral virtue foundational to such quality, review and contest some grounds on which children have been regarded as not mature enough to have friendships that require virtue, and report a qualitative study of the friendship assessments and aspirations of children aged nine and ten (n = 83). In focus group sessions conducted in ten schools across Great Britain, moral qualities figured prominently in children's assessments of friendship quality. The findings provide evidence of children having friendships exhibiting mutual respect, support, and valuing of each other's good character.