Optimal designs for tumor regrowth models

Most growth curves can only be used to model the tumor growth under no intervention. To model the growth curves for treated tumor, both the growth delay due to the treatment and the regrowth of the tumor after the treatment need to be taken into account. In this paper, we consider two tumor regrowth models and determine the locally D- and c-optimal designs for these models. We then show that the locally D- and c-optimal designs are minimally supported. We also consider two equally spaced designs as alternative designs and evaluate their efficiencies.     

A stable estimator of the information matrix under EM for dependent data

This article develops a new and stable estimator for information matrix when the EM algorithm is used in maximum likelihood estimation. This estimator is constructed using the smoothed individual complete-data scores that are readily available from running the EM algorithm. The method works for dependent data sets and when the expectation step is an irregular function of the conditioning parameters. In comparison to the approach of Louis (J. R. Stat. Soc., Ser. B 44:226–233, 1982), this new estimator is more stable and easier to implement. Both real and simulated data are used to demonstrate the use of this new estimator.     

Coupon collector's problem and generalized Pareto distributions

Let N_n={1,2,…,n}. We sample with replacement from the set N_n assuming that each element has probability 1/n of being drawn. Let M_n be the waiting time determined by certain stoping rules in the coupon collector's problem. We investigate models for the asymptotic behavior of the excesses of M_n over the high thresholds.     

On some mixture models based on the Birnbaum-Saunders distribution and associated inference

In this paper, we consider three different mixture models based on the Birnbaum-Saunders (BS) distribution, viz., (1) mixture of two different BS distributions, (2) mixture of a BS distribution and a length-biased version of another BS distribution, and (3) mixture of a BS distribution and its length-biased version. For all these models, we study their characteristics including the shape of their density and hazard rate functions. For the maximum likelihood estimation of the model parameters, we use the EM algorithm. For the purpose of illustration, we analyze two data sets related to enzyme and depressive condition problems. In the case of the enzyme data, it is shown that Model 1 provides the best fit, while for the depressive condition data, it is shown all three models fit well with Model 3 providing the best fit.     

On simultaneous closeness probabilities of order statistics from odd sample sizes to the population median

In this note, we present alternative derivations for the probability that an individual order statistic is closest to the target parameter among all order statistics from a complete random sample. This approach is simpler than the geometric arguments used earlier. We also provide a simple direct proof for the symmetry property of the simultaneous closeness probabilities among order statistics for the estimation of percentiles from a symmetric family. Finally, we offer an alternative simpler proof for the result that sample medians from larger odd sample sizes are Pitman closer to the population median than sample medians from smaller odd sample sizes.     

Determinants of Social Expenditure in Sri Lanka

The study examines the determinants of social expenditure in Sri Lanka for the period 1970–2010. The data are from a new data set assembled by the authors. The social spending data are collected from the Central Bank of Sri Lanka on education, health, and also on welfare spending. The study explains the determinants of social spending considering the demand‐side and the supply‐side driving forces and finds that inequality issues have been a major concern of social policy in Sri Lanka. Similarly, this study implies the influence of political behavior to satisfy voters as explained by the fiscal illusion theory. The globalization is not significant for social expenditure as commonly assumed in developed countries. Even the consequences of the self‐interested behavior of bureaucrats are not evident in the Sri Lankan welfare sector.     

Extending the Mann–Whitney–Wilcoxon rank sum test to longitudinal regression analysis

Outliers are commonly observed in psychosocial research, generally resulting in biased estimates when comparing group differences using popular mean-based models such as the analysis of variance model. Rank-based methods such as the popular Mann–Whitney–Wilcoxon (MWW) rank sum test are more effective to address such outliers. However, available methods for inference are limited to cross-sectional data and cannot be applied to longitudinal studies under missing data. In this paper, we propose a generalized MWW test for comparing multiple groups with covariates within a longitudinal data setting, by utilizing the functional response models. Inference is based on a class of U-statistics-based weighted generalized estimating equations, providing consistent and asymptotically normal estimates not only under complete but missing data as well. The proposed approach is illustrated with both real and simulated study data.     

On- and offline detection of structural breaks in thermal spraying processes

We investigate and develop methods for structural break detection, considering time series from thermal spraying process monitoring. Since engineers induce technical malfunctions during the processes, the time series exhibit structural breaks at known time points, giving us valuable information to conduct the investigations. First, we consider a recently developed robust online (also real-time) filtering (i.e. smoothing) procedure that comprises a test for local linearity. This test rejects when jumps and trend changes are present, so that it can also be useful to detect such structural breaks online. Second, based on the filtering procedure we develop a robust method for the online detection of ongoing trends. We investigate these two methods as to the online detection of structural breaks by simulations and applications to the time series from the manipulated spraying processes. Third, we consider a recently developed fluctuation test for constant variances that can be applied offline, i.e. after the whole time series has been observed, to control the spraying results. Since this test is not reliable when jumps are present in the time series, we suggest data transformation based on filtering and demonstrate that this transformation makes the test applicable.     

The k-sample problem in a multi-state model and testing transition probability matrices

The choice of multi-state models is natural in analysis of survival data, e.g., when the subjects in a study pass through different states like ‘healthy’, ‘in a state of remission’, ‘relapse’ or ‘dead’ in a health related quality of life study. Competing risks is another common instance of the use of multi-state models. Statistical inference for such event history data can be carried out by assuming a stochastic process model. Under such a setting, comparison of the event history data generated by two different treatments calls for testing equality of the corresponding transition probability matrices. The present paper proposes solution to this class of problems by assuming a non-homogeneous Markov process to describe the transitions among the health states. A class of test statistics are derived for comparison of \(k\) treatments by using a ‘weight process’. This class, in particular, yields generalisations of the log-rank, Gehan, Peto–Peto and Harrington–Fleming tests. For an intrinsic comparison of the treatments, the ‘leave-one-out’ jackknife method is employed for identifying influential observations. The proposed methods are then used to develop the Kolmogorov–Smirnov type supremum tests corresponding to the various extended tests. To demonstrate the usefulness of the test procedures developed, a simulation study was carried out and an application to the Trial V data provided by International Breast Cancer Study Group is discussed.