A Bayesian compartmental model for the evaluation of 1,3-butadiene metabolism

Summary. We propose a Bayesian model for physiologically based pharmacokinetics of 1,3-butadiene (BD). BD is classified as a suspected human carcinogen and exposure to it is common, especially through cigarette smoke as well as in urban settings. The main aim of the methodology and analysis that are presented here is to quantify variability in the rates of BD metabolism by human subjects. A three-compartmental model is described, together with informative prior distributions for the population parameters, all of which represent real physiological variables. The model is described in detail along with the meanings and interpretations of the associated parameters. A four-compartment model is also given for comparison. Markov chain Monte Carlo methods are described for fitting the model proposed. The model is fitted to toxicokinetic data obtained from 133 healthy subjects (males and females) from the four major racial groups in the USA, with ages ranging from 19 to 62 years. Subjects were exposed to 2 parts per million of BD for 20 min through a face mask by using a computer-controlled exposure and respiratory monitoring system. Stratification by ethnic group results in major changes in the physiological parameters. Sex and age were also tested but not found to have a significant effect.     

Fine‐Grained Analysis of Motionese: Eye Gaze,Object Exchanges,and Action Units in Infant‐Versus Adult‐Directed Action

Mothers modify their actions when demonstrating objects to infants versus adults. Such modifications have been called infant‐directed action (IDA) or motionese (Brand, Baldwin, & Ashburn, 2002). We investigated the IDA features of interactiveness and simplification by quantifying eye gaze, object exchanges, and action units enacted between exchanges in 42 mothers' demonstrations of novel objects to infants (6–8 months or 11–13 months) or adults. We found more eye gaze, more object exchanges, and fewer action types per turn in demonstrations to infants relative to adults. Unlike prior research using global measurements, we detected differences in behavior directed at infants of different ages: Shorter, more frequent gazes and more exchanges characterized demonstrations to older versus younger infants. These findings indicate the fruitfulness of fine‐grained analysis of IDA, and further clarify how adults may support infants' processing of human motion.     

Volunteerism During Young Adulthood: An Italian Investigation into Motivational Patterns

This paper explores the motivational frame of Italian young adults involved in volunteerism and its relation to several variables included in Omoto and Snyder’s Volunteer Process Model framework. Some 461 Italian young adults (aged 24–31) involved in voluntary activities with children and adolescents were considered. Referring to Omoto and Snyder’s functionalist and motivational framework, a Ward’s method cluster analysis was performed to identify specific patterns of motivations originating from the aggregation of 4 factors of motivation (social, career, ego-protective, and values) measured with the Voluntary Function Inventory (VFI). The results show that young volunteers are inspired by a distinctive and composite pattern of motivations, including both self and other-oriented motivations. Multiple motivations underlying the activities are associated to satisfaction and good integration in the organization confirming that people spurred by more than one motivation are less vulnerable to costs related to the activity and are more likely to maintain a longer involvement.

The role of sadism and peer pressure in the sexual aggression of male college students

Two types of motivational models help explain sexual aggression in college men. Socialization models emphasize imperatives of the male sex role, whereas a sadistic model focuses on increased sexual stimulation from female distress. These models were evaluated by comparing the relationship between a measure of sexual sadism and the frequency of sexually aggressive episodes with the relationship between peer pressure for sexual intimacy and sexual aggression. College men's ratings of sexual attractiveness for a series of female faces registering both pleasant and distressed affects were used to measure sexual sadism. Results showed that 60% of the college men with a sexual sadism pattern reported repeated episodes of sexual aggression since the 10th grade, whereas only 29% of those not showing this pattern did so. Peer pressure was inversely related to repeated aggression; sexual aggressives reported less peer pressure than students who did not have a history of repeated aggression. These results are not only important because they identify a possible source of sexual aggression toward females but also because they encourage an interest in discovering how sexual and aggressive motives become fused in a significant proportion of normal males.     

Quality in K-12 education: Parameters for world class achievement

It is widely believed by the American public that quality education is an unattainable goal in American elementary and secondary schools. A recent survey of twelfth grade students in the thirteen leading developed countries showed that American students ranked thirteenth. Another recent survey concluded that 25 million of our citizens are functionally illiterate and that an additional 25 million have to update their skills and/or knowledge to remain competitive in today's marketplace. The federal government and some state governments have finally recognized the relatively poor condition of our present educational system and have set initiatives to corect the educational crisis that exists. The authors describe former President Bush's “America 2000: An Educational Strategy” and President Clinton's “GOALS 2000: Educate America”, both of which have desirable goals but lack an approach for reaching the target and fail to specify any type of accountability for non-achievement. The authors then compare the American education system to an industrial or service organization and attempt to define the “customer”. Once the “customer” is identified, Deming's principles for management are shown to apply to education as well as to manufacturing and other service organizations. In developing this paper, the authors focus on:

1. government, initiatives to improve the educational environment,
2. the views of leading experts on the applicability of total quality management concepts to education, and
3. the strides that have been made toward educational quality improvement by some schools.

A case study describing the benefits which have resulted from implementation of a total quality system at an inner-city suburban New York City K-12 school is then presented.     

Constructing Gay and Lesbian Parent Families “Beyond the Closet”

This paper provides a multilayered analysis of how lesbian mothers and gay fathers construct their families in a social context that has been described by Steven Seidman (2004) as “beyond the closet.” We stress how our participants’ family-building experiences are comparable to other non-biologically related families, but distinct due to heterosexual dominance. Using in-depth qualitative interviews with 18 lesbian birth mothers and 22 gay fathers, the authors discuss how participants navigate heterosexual dominance in institutions and in personal interactions.

The Relation Between Participatory Social Practices and Social Representations of Citizenship in Young Adulthood

The concept of citizenship is used both as a synonym of social action when referencing to an active form of citizenship as well as to indicate a form of civic obligation (formal citizenship). According to these premises, citizenship can be formalized in a large number of activities that contribute to building it in different ways. The aim of the present work is to explore how the concepts of citizenship and being a citizen are co-built by Italian young adults. Two groups of young adults are considered (engaged vs. not engaged). Eighty-nine young adults participants aged 18–36 completed a self-administered mixed-method questionnaire. A content and thematic analysis was conducted and a composite representation of citizenship emerged. Results of the present work can clarify the concept of citizenship by exploring how it is cognitively and socially represented in young adults and how this representation changes in engaged and not engaged young adults.     

Labour Market Flexibility,Human Resource Management and Corporate Performance

Labour market flexibility is often portrayed as a key to the competitive success of the UK and US economies. We surveyed several hundred firms in the UK, and using the resulting data (on over 200 manufacturing firms) this paper investigates the relationships between firms’ use of flexible work practices, human resource systems and industrial relations on the one hand, and corporate performance on the other hand. The results suggest that ‘low‐road’ practices – short‐term contracts, a lack of employer commitment to job security, low levels of training and low levels of human resource sophistication – are negatively correlated with corporate performance. In contrast, it is found that ‘high‐road’ work practices –‘high commitment’ organizations or ‘transformed’ workplaces – are positively correlated with good corporate performance. It is also found that human resource management practices are more likely to contribute to competitive success where they are introduced as a comprehensive package, or ‘bundle’ of practices. Significant interaction effects between human resource systems, trade unions and flexible work practices add further support to the bundling hypothesis.