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We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified power with a saving of sample size compared to existing adaptive designs. A method is also proposed to obtain a reduced-bias estimator of treatment difference for the proposed design. The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials. Operating characteristics are evaluated and compared with other group sequential designs in empirical studies. An example is provided to illustrate the application of the method. 相似文献
23.
A Monte Carlo simulation was conducted to compare the type I error rate and test power of the analysis of means (ANOM) test to the one-way analysis of variance F-test (ANOVA-F). Simulation results showed that as long as the homogeneity of the variance assumption was satisfied, regardless of the shape of the distribution, number of group and the combination of observations, both ANOVA-F and ANOM test have displayed similar type I error rates. However, both tests have been negatively affected from the heterogeneity of the variances. This case became more obvious when the variance ratios increased. The test power values of both tests changed with respect to the effect size (Δ), variance ratio and sample size combinations. As long as the variances are homogeneous, ANOVA-F and ANOM test have similar powers except unbalanced cases. Under unbalanced conditions, the ANOVA-F was observed to be powerful than the ANOM-test. On the other hand, an increase in total number of observations caused the power values of ANOVA-F and ANOM test approach to each other. The relations between effect size (Δ) and the variance ratios affected the test power, especially when the sample sizes are not equal. As ANOVA-F has become to be superior in some of the experimental conditions being considered, ANOM is superior in the others. However, generally, when the populations with large mean have larger variances as well, ANOM test has been seen to be superior. On the other hand, when the populations with large mean have small variances, generally, ANOVA-F has observed to be superior. The situation became clearer when the number of the groups is 4 or 5. 相似文献
24.
Three parameters—sample size, sampling intervals, and the control limits—must be determined when the x bar chart to monitor a manufacturing process. The constant sampling intervals were widely employed because of its administrative simplicity. However, the variable sampling interval (VSI) has recently been shown to give substantially faster detection of most process shifts than fixed-sampling-interval (FSI) for x-bar charts. In addition, these measurements in the subgroup are assumed to be normally distributed. That assumption may not be tenable. This investigation compares the economic design of x-bar control charts for non normal data under Weibull shock models with various sampling avenues. 相似文献
25.
This article proposes a new spatial cluster detection method for longitudinal outcomes that detects neighborhoods and regions with elevated rates of disease while controlling for individual level confounders. The proposed method, CumResPerm, utilizes cumulative geographic residuals through a permutation test to detect potential clusters which are defined as sets of administrative regions, such as a town or group of administrative regions. Previous cluster detection methods are not able to incorporate individual level data including covariate adjustment, while still being able to define potential clusters using informative neighborhood or town boundaries. Often, it is of interest to detect such spatial clusters because individuals residing in a town may have similar environmental exposures or socioeconomic backgrounds due to administrative reasons, such as zoning laws. Therefore, these boundaries can be very informative and more relevant than arbitrary clusters such as the standard circle or square. Application of the CumResPerm method will be illustrated by the Home Allergens and Asthma prospective cohort study analyzing the relationship between area or neighborhood residence and repeated measured outcome, occurrence of wheeze in the last six months, while taking into account mobile locations. 相似文献
26.
Adaptive designs of clinical trials are ethical alternatives when the traditional randomization becomes ethically infeasible in desperate medical situations. However, such a design creates a dependency among trial data and its statistical analysis becomes more complex than the analysis for traditional randomized clinical trials. In this article, we examine adaptive designs with dichotomous responses from two treatments and extend some commonly used statistical methods for independent data. Under a regularity condition, the estimated odds ratio and its logarithm are shown to follow asymptotically normal distributions. Moreover, the ordinary goodness-of-fit test statistic for two-by-two contingency tables with dependent data is shown to be asymptotically chi-square distributed. We also discuss the consistency of maximum likelihood estimators of the unknown parameters for a wide class of adaptive designs. 相似文献
27.
中国城市化与生态环境协调发展预警系统研究 总被引:5,自引:0,他引:5
本文构建了城市化与生态环境协调发展预警指标体系,并对1991~2010年中国城市化与生态环境的协调度进行了测算及预测,根据协调度建立了预警系统,并对90年代以来中国城市化与生态环境的协调发展进行了分析。结果表明,2007年以来,中国的生态环境不断恶化,城市化与生态环境的协调度不断下降,保护生态环境成为城市化进程中的重要问题。 相似文献
28.
改进的投影寻踪分类模型及其在区域经济评价中的应用 总被引:2,自引:0,他引:2
作为多元数据的一种分析方法,投影寻踪分类模型已被一些研究者应用到实践中,并取得了良好的效果.然而,投影寻踪分类模型没有严格意义上的分类标准.通过引入有序样本聚类法,可以对投影寻踪分类模型得到的一维投影值进行客观分类.根据改进的模型,对江苏省区域经济的发展进行了综合评价,结果表明:改进的投影寻踪分类模型切实可行,为多元数据分类提供了新途径. 相似文献
29.
王意 《河北工程大学学报(社会科学版)》2008,25(2):110-111
大学物理课堂上很少作演示实验,课容量大,内容抽象,根据这一特点,大学物理课堂上的提问就有其自身的特点。课堂提问在整个教学环节中有着极其重要的作用,提问的方式方法不同,产生的效果往往会发生根本的变化。因此,课堂提问应该注意提问的对象、提问的范围、提问的多样性、提问的针对性等等问题。 相似文献
30.
甲骨文的发现迄今已一百年,因甲骨文之发现,甲古学由是创建,并已成为一门显学。治甲骨学之中坚五氏同“堂”;罗振玉,号雪堂;王国维,号观堂;董作宾,号彦堂;郭沫若,号鼎堂;饶宗颐,号选堂。从世界范围审视,19世纪系破译古文字与释读其文献之前弘期;20世纪则是破译古文字与释读其文献之辉煌期,亦即治古文字这之辉煌期。 相似文献