Modeling the Adenoma and Serrated Pathway to Colorectal CAncer (ASCCA)

Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of colorectal lesions may provide overly optimistic predictions of the screen‐induced reduction in CRC incidence. To address this issue, we have developed the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model that includes the adenoma‐carcinoma pathway and the serrated pathway to CRC as well as characteristics of colorectal lesions. The model structure and the calibration procedure are described in detail. Calibration resulted in 19 parameter sets for the adenoma‐carcinoma pathway and 13 for the serrated pathway that match the age‐ and sex‐specific adenoma and serrated lesion prevalence in the COlonoscopy versus COlonography Screening (COCOS) trial, Dutch CRC incidence and mortality rates, and a number of other intermediate outcomes concerning characteristics of colorectal lesions. As an example, we simulated outcomes for a biennial fecal immunochemical test screening program and a hypothetical one‐time colonoscopy screening program. Inclusion of the serrated pathway influenced the predicted effectiveness of screening when serrated lesions are associated with lower screening test sensitivity or when they are not removed. To our knowledge, this is the first model that explicitly includes the serrated pathway and characteristics of colorectal lesions. It is suitable for the evaluation of the (cost)effectiveness of potential screening strategies for CRC.     

Simulating space-time random fields with nonseparable Gneiting-type covariance functions

Statistics and Computing - Two algorithms are proposed to simulate space-time Gaussian random fields with a covariance function belonging to an extended Gneiting class, the definition of which...     

Model averaging inconcentration–QT analyses

This article describes how a frequentist model averaging approach can be used for concentration–QT analyses in the context of thorough QTc studies. Based on simulations, we have concluded that starting from three candidate model families (linear, exponential, and Emax) the model averaging approach leads to treatment effect estimates that are quite robust with respect to the control of the type I error in nearly all simulated scenarios; in particular, with the model averaging approach, the type I error appears less sensitive to model misspecification than the widely used linear model. We noticed also few differences in terms of performance between the model averaging approach and the more classical model selection approach, but we believe that, despite both can be recommended in practice, the model averaging approach can be more appealing because of some deficiencies of model selection approach pointed out in the literature. We think that a model averaging or model selection approach should be systematically considered for conducting concentration–QT analyses. Copyright © 2016 John Wiley & Sons, Ltd.     

Comparison of hazard rates for dependent random variables

In this paper, we define and study a new notion for the comparison of the hazard rates of two random variables taking into account their mutual dependence. Properties, applications and the comparison for a data set are given.     

Conditional VAR and Expected Shortfall: A New Functional Approach

We estimate two well-known risk measures, the value-at-risk (VAR) and the expected shortfall, conditionally to a functional variable (i.e., a random variable valued in some semi(pseudo)-metric space). We use nonparametric kernel estimation for constructing estimators of these quantities, under general dependence conditions. Theoretical properties are stated whereas practical aspects are illustrated on simulated data: nonlinear functional and GARCH(1,1) models. Some ideas on bandwidth selection using bootstrap are introduced. Finally, an empirical example is given through data of the S&P 500 time series.     

Fatigue management by truck drivers in real life situations: some suggestions to improve training

Truck driver fatigue is a major safety issue for truck drivers and the public in general. Although training prepares drivers to effectively operate a truck, it tends to minimize the importance of working constraints faced daily on-the-job and thus reduces its impact on safety and effectiveness. With experience, drivers develop skills to combat fatigue. Documenting these skills can contribute to improved training of apprentices. An ethnographic approach was used to better understand the real-life fatigue management skills of truck drivers. Participant observation was used to analyze the activity of apprentices in training and the activity of truck drivers at work. Observations indicated that training focused on time management and regulations, but did not prepare trainees to manage real-life constraints. Experienced drivers were not merely managing time; rather they were managing working constraints (including time) as a whole. To do so, they used two strategies: managing psycho-physical transformations and dynamic work planning. By integrating psycho-physical preoccupations into all aspects of work and by preparing future drivers to face real-life constraints, we could better train and prepare apprentices. Drivers do develop effective skills to combat fatigue which can improve training and better prepare future drivers to face daily constraints. These improvements can have a significant impact on fatigue and safety in the transportation industry.     

Gender differences in the relationship between intimate partner violence victimization and the perception of dating situations among college students

Although the prevalence and severity of dating violence among college students is well known, the relationship between past victimization and perceptions of future dating situations has not been examined. Using both qualitative and quantitative research methods, this study investigated gender differences in the relationship between intimate partner violence victimization and the perceptions of dating situations. The study found that the more psychological, physical, or sexual violence that was experienced by females, the more likely they perceived dating situations as inappropriate. Males, on the other hand, were more likely to report aggressive behaviors in dating situations only if victimized by sexual violence. Implications for professionals working with college students or community prevention programs are discussed.     

Barrios and burbs: residential context and health-risk behaviors among Angeleno adolescents

The increasing size of the Latino immigrant population in the United States underscores the need for a more complete understanding of the role that social context plays in influencing the health of immigrants and their children. This analysis explores the possibility that residential location influences the health-risk behaviors of Latino youth in Los Angeles County, California. The data come from the Los Angeles Family and Neighborhood Survey. We apply multivariate, multilevel Rasch models to two scales of adolescent health-risk behaviors (substance use and delinquency). The findings suggest that residence in Census tracts characterized by above-county-average levels of Latinos and above-county-average levels of poverty is associated with increased odds of health-risk behaviors for Latino adolescents, particularly for those born in the United States. The findings lend support to the contention, put forth in the segmented assimilation literature, that disadvantaged urban contexts increase the risk that U.S.-born children of immigrants will experience downward assimilation.     

How Satisfied are Spouses with their Leisure Time? Evidence from Europe

This paper first identifies the determinants of spouses’ satisfaction levels within the household with respect to their leisure time and, secondly, characterizes whether their preferences have some degree of altruistic or egoistic character in regard to this particular satisfaction. To that end, it formulates a theoretical framework from the collective family model whose stochastic formulations are estimated for 14 EU countries. The general empirical results first reveal that the presence of children has a significantly negative impact on the leisure satisfaction of both spouses. Then, increases in individual incomes lead to lower own leisure satisfaction levels. Both husbands and wives show egoistic behavior with respect to the labor and non-labor incomes (wage rate) of their respective spouses’ satisfaction levels.