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61.
The capacity of skeletal muscles to repair and regenerate declines during aging in humans, and this decline may lead to muscle loss and frailty. Conboy et al. show that injured muscles of aging mice are defective in Notch signaling, because up-regulation of the Notch ligand, Delta-1, is impaired. Delta-1 promotes proliferation of the satellite cells that repair damaged muscles, and Conboy et al. show that experimental activation of Notch signaling is sufficient to reverse the age-related decline in muscle regenerative capacity. Extension of these important findings to humans could lead to the development of new therapeutic approaches to maintain muscle function during aging. 相似文献
62.
Moe CL Christmas WA Echols LJ Miller SE 《Journal of American college health : J of ACH》2001,50(2):57-66
Norwalk-like viruses (NLVs) are transmitted by fecally contaminated food, water, fomites, and person-to-person contact. They are a leading cause of acute gastroenteritis epidemics in industrialized countries. NLV outbreaks are characterized by a 12- to 48-hour incubation period; nausea, vomiting, and diarrhea for 24 to 72 hours; and high secondary attack rates. NLV infections spread rapidly on college and university campuses because of close living quarters, shared bathrooms and common rooms, many food handlers, popular self-service salad bars in dining halls, and person-to-person contact through sports and recreational activities. The illness is generally mild and self-limited but an outbreak can strain the resources of campus health services and cause high absenteeism among both students and staff. Treatment is primarily through antiemetic medication and oral rehydration. Prevention and control of NLV outbreaks rests on promoting hand washing; enforcement of strict hygiene in all food preparation areas; and prompt, rigorous cleaning of potentially contaminated areas where someone has been ill. 相似文献
63.
Functional Capacity Evaluations (FCEs) have become the standard for identifying an individual's physical abilities and/or limitations following injury or illness. While philosophies and approaches differ, the focus of most FCE systems is to identify the individual's maximum capabilities. This article will discuss the usefulness of the FCE information and how FCEs are impacted by multiple factors including APTA guidelines, machine based testing, therapist expertise, medical legal credibility and court testimony, IMEs and FCE, and return to work/return to function. 相似文献
64.
conclusion The Information Age has revolutionized the workplace. While it is possible to purchase or copy machines and technology, their
very interchangeability means they fail to cre-ate a sustained competitive advantage for an organization (Barney, 1991). The
research directions this paper offers are intended to develop firm knowledge that allows creation of inimitable human resources.
Importantly, in the rush to embrace new information technologies, organizations must remember the fundamental principle that
workers will invest in firm goals in the presence of shared values and a commitment by the firm to make their well-being a
priority. We urge continued attention to fulfillment of the psy-chological contract, and to the "people issues" that frequently
seem less critical than issues of hardware or technology. 相似文献
65.
Protecting and conserving environmental resources is a global concern. Over the past decade, a number of certification processes have emerged to help designers and operators of buildings assess the potential impact of a building on the environment. Certifications such as the Leadership in Energy and Environmental Design (LEED) consider the environmental impact through the lifecycle of a building, but may not be considering the people that construct and utilize it. It is important to remember the human factor. Considering the human factor throughout the lifecycle is crucial to ensure individuals are protected during construction and in operation in the built environment. The paper highlights how ergonomics can be integrated into the life cycle of a building to promote sustainability goals for both the human factor and the environment. A case study approach will be used to illustrate how ergonomics was integrated into a LEED renovation and expanded into its daily operations on a large university campus.. 相似文献
66.
Miller BC 《Journal of Family and Economic Issues》1992,13(4):467-475
Adolescent parenthood has highly publicized adverse social and economic consequences, but these same social and economic disadvantages can be viewed as root causes of adolescent pregnancy. Recent research and revisionist debates about these issues are reviewed and summarized. Diverse implications for social policy are considered. Prevention approaches are emphasized that build on both postponing adolescent sexual intercourse and helping sexually active teens avoid pregnancy.Appreciation is expressed to Christine Bachrach and Kristin Moore for their comments on a previous version of this paper.Dr. Miller's current research interests are the family antecedents of adolescent sexual behavior and the design and evaluation of prevention programs for adolescent problem behaviors. He received his Ph.D. in family sociology from the University of Minnesota in 1975. 相似文献
67.
Lucas G. Gago Galvagno Stephanie E. Miller Carolina De Grandis Angel M. Elgier 《Infancy》2021,26(6):962-979
Recent work within early executive function (EF) seems to suggest that toddlers show distinct patterns of development, involving poorly correlated performance across EF tasks and significant improvements over relatively short periods of time. The present study sought to extend these findings by investigating evidence for these patterns in toddlers and the existence of more traditional patterns of EF (e.g., correlations between tasks, links to language) when using the same tasks in a novel Latin American sample. Eighty toddlers (18–24 months) and sixty young preschoolers (30–36) months completed a battery of EF tasks, early social communication, and receptive and expressive language measures. Results indicated that toddlers showed similar distinct patterns of development (i.e., few relations between tasks and links to responding to joint attention), but by early preschool a more cohesive EF and links to language were present. Further, work demonstrated significant age (older children outperformed younger children), gender (girls outperformed boys), and socioeconomic differences (satisfied basic needs outperformed unsatisfied basic needs, but only on the snack delay). This work provides evidence for patterns of emerging EF development within this novel cultural sample (and evidence for group differences) that may be supported by communicative and representational development. 相似文献
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