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Bayesian methods for the cross-design synthesis of epidemiological and toxicological evidence 总被引:1,自引:0,他引:1
Jaime L. Peters Lesley Rushton Alex J. Sutton David R. Jones Keith R. Abrams Moira A. Mugglestone 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(1):159-172
Summary. Systematic review and synthesis (meta-analysis) methods are now increasingly used in many areas of health care research. We investigate the potential usefulness of these methods for combining human and animal data in human health risk assessment of exposure to environmental chemicals. Currently, risk assessments are often based on narrative review and expert judgment, but systematic review and formal synthesis methods offer a more transparent and rigorous approach. The method is illustrated by using the example of trihalomethane exposure and its possible association with low birth weight. A systematic literature review identified 13 relevant studies (five epidemiological and eight toxicological). Study-specific dose–response slope estimates were obtained for each of the studies and synthesized by using Bayesian meta-analysis models. Sensitivity analyses of the results obtained to the assumptions made suggest that some assumptions are critical. It is concluded that systematic review methods should be used in the synthesis of evidence for environmental standard setting, that meta-analysis will often be a valuable approach in these contexts and that sensitivity analyses are an important component of the approach whether or not formal synthesis methods (such as systematic review and meta-analysis) are used. 相似文献
945.
We document social inequalities in cause-specific mortality at ages 35–64 in Finland and the United States, countries with different health systems, income distributions, and social welfare programs for the working-aged population. The education–mortality gradient was the most marked for Finnish men and for causes of death linked to risk-taking, health behaviors, and stress. The association between family income and mortality was curvilinear in both countries. The effects of education and income were strongly attenuated after controlling for each other, marital status, and labor force participation, with the greatest attenuation observed for income in Finland and education in the United States.Elo, I. T., Martikainen, P., et Smith, K. P. (2006). Mortalité sociale en Finlande et aux Etats-Unis: Róle du niveau d'instruction et du revenu. Revue Europeéenne de démographie, 22, 177–201 相似文献
946.
Russell C. Smith D. Eugene Mead Judith A. Kinsella 《Journal of marital and family therapy》1998,24(1):113-125
This is a critical review of live supervision with emphasis on technical innovations such as earphones or bug-in-the-ear, Teleprompters, and computers. A computer-assisted approach is described that overcomes many criticisms of live supervision. Direct supervision uses a computer monitor to unobtrusively provide information to the therapist about the supervisor's perceptions of the clients' and therapist's behavior, the expected therapeutic behaviors, and the therapist's "on target" behavior. Direct supervision has the advantage over other forms of supervision by providing an immediate, continuous, and permanent record for postsession supervision and for research into the supervisor-therapist-client process. The paper provides several suggestions for research. 相似文献
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The field of dynamic capabilities has developed very rapidly over the last ten years. In this paper we discuss the evolution of the concept, and identify two major current debates around the nature of dynamic capabilities and their consequences. We then review recent progress as background to identifying the contributions of the seven papers in this special issue, and discuss the relative merits of qualitative and quantitative studies for investigating dynamic capabilities. We conclude with recommendations for future research arguing for more longitudinal studies which can examine the processes of dynamic abilities over time, and for studies in diverse industries and national contexts. 相似文献
950.
Sociological literature lacks a firm evidentiary base with respect to how mass media usage works to forge patterns of collective attachment among socially diverse individuals within contemporary societies. This paper seeks to engage with this absence by examining the detailed ways in which complexities of media consumptions are linked with divergent popular visions of national belongingness and identity. Focusing in particular on variations in cultural genre and delivery technology, the study aims to help clarify extant disciplinary discussions about if and how media consumption interconnects with the substance of individual national imaginings in an era of cultural globalization. Using data from a large social survey of changing visions of national identity among contemporary Australians, the study shows that established media technologies and the consumption of lowbrow genres harden individual attachment to a traditional imagining of the nation. By contrast use of the Internet and highbrow genres foster a more inclusive vision of nation identity. In terms of sustaining these different national identity configurations, cultural genre is revealed to be of greater consequence than technological medium. Furthermore, and in a more general way, the findings suggest that notwithstanding the complexity of effects, mass media usage stands up alongside a more established concern with individual social structural background as a highly salient factor in shaping contemporary formations of national attachment. 相似文献