Application of multivariate longitudinal models in SIRT6, FBS,and BMI analysis of the elderly

Abstract

Objective: SIRT6 is a main regulator of metabolism and lifespan and its importance has been implicated in the prevention against aging-related diseases. The objective of this study was to examine the application of multivariate longitudinal models in SIRT6, FBS, and BMI analysis in the elderly men after eight weeks concurrent training with supplementation of l-arginine (l-Arg).

Methods: Thirty two elderly men with mean age of 63.09?±?3.71 years were randomly divided into four equal-sized groups (each n?=?8); Exercise?+?supplement (ES) group; exercise?+?placebo (EP) group; supplement (S) group and control (C) group. The ES and EP groups performed the eight weeks of concurrent training, three sessions per week. Group ES and group S consumed 1000?mg of l-Arg per day at 8:00?pm. Measurements of biochemical variables were done by ELISA Reader method. For analytical purposes, we used the paired sample t-test and multivariate longitudinal modeling with generalized estimating equation (GEE) methodology. All analyses have been implemented in R-3.4.1. p Values less than .05 were considered statistically significant.

Results: With respect to significant association between sirt6, FBS, and BMI, this study showed that synergy effect of training and supplementation was greater than the sum of their individual effects on SIRT6 (β?=?0.79, p?<?.001), FBS (β?=??5.56, p?=?.022), and BMI (β?=??3.89; p?=?.041). Also exercise alone had a significantly larger effect than supplementation alone on responses.

Conclusions: It can be concluded that the joint usage of concurrent training and supplement of l-Arg for elderly men could improve the metabolism and body composition.     

Traditional and innovated gambling products: an exploration of player preferences

There is concern that recent innovations of traditional face-to-face gambling products may lead to increased harm because of the tendency for innovated products to share certain structural features with electronic gaming machines (EGMs). The VICES framework focusses on several mechanisms known to influence gambling behaviour: visual and auditory enhancements, illusions of control, cognitive complexity, expedited play and social customization. The current study applied the VICES framework to an investigation of player experiences with both traditional and innovated gambling products. Through a series of six focus groups (N = 40) with regular bingo, poker and casino table game players and sports bettors, we examined the characteristics of innovated gambling products and their influences on player experience and the risk of gambling harm. Findings suggest that traditional games are perceived as more social, more enjoyable and less harmful. This was largely attributed to the low social interaction, expedited play and increased potential for consumption that is associated with EGM-type gambling activity. Further, we suggest that VICES, pending some revision, is a valid and applicable framework by which to identify characteristics of innovated products that influence player experience and behaviour.     

Co-Shaping Metacognitive Awareness and Developing Listening Comprehension through Process-Based Instruction

This study examined the effect of metacognitive process-based and product-based instruction on enhancing listening comprehension and metacognitive awareness. Two classes of high-beginner English as a foreign language learners were randomly assigned to two groups: product-based (n = 30) process-based (n = 30). Both before and after eight instructional sessions, listening comprehension and metacognitive awareness were measured. Process-based group, then, followed a pedagogical sequence in each session (Vandergrift, 2004), providing opportunities for dialogue about the listening process and the strategies involved, whereas the product-based group was not engaged in dialogue nor did the group reflect upon listening strategies. Results indicated that the process-based group significantly outperformed the product-based one in terms of gains in listening comprehension and metacognitive awareness. Moreover, the microgenetic analysis of the dialogic interactions of the process-based group presented some evidence showing how the students co-shaped metacognitive awareness. This article concludes with discussing the findings, presenting some pedagogical implications, and sketching out areas for further research.     

Bhutanese refugee adolescents’ school adjustment: the role of acculturation and familial social capital

With the rise of conflict, persecution, and generalised violence worldwide there has been a drastic increase in the number of refugee youth displaced globally. Particularly noteworthy is the recent increase of Bhutanese refugee youth populations resettled in the United States. Despite this increase, surprisingly few studies distinctly address the promotive factors related to refugee youth’s successful adjustment within their new school settings upon resettlement. This study aims to add to the scholarship through a resiliency lens. The potential promotive associations of familial social capital and acculturation identity on Bhutanese refugee youth’s successful school adjustment were explored. Moreover, this study examined the unique additive predictive association of familial social capital on Bhutanese refugee youth’s school adjustment over and above the effects of acculturation. The results indicate a significant additive positive relationship between familial social capital and school adjustment, beyond the effects of ethnic identity.     

Bayesian Updating with Confounded Signals

We develop a Bayesian framework for estimating the means of two random variables when only the sum of those random variables can be observed. Mixture models are proposed for establishing conjugacy between the joint prior distribution and the distribution for observations. Among other desirable features, conjugate distributions allow Bayesian methods to be applied in sequential decision problems.     

Gambling Behavior Among Adolescents with Attention Deficit/Hyperactivity Disorder

Impulsivity is inherent to both problem gambling and ADHD. The purpose of this study is to examine ADHD key symptoms, and gambling behaviors and problem severity among adolescents. Additionally, internalizing and externalizing behaviors exhibited among these individuals and the role of these symptoms in gambling are examined. We used a cross-sectional study design and survey 1,130 adolescents aged 12–19. Results indicated that adolescents who screened positive for ADHD were significantly more likely than non-ADHD adolescents to engage in gambling and significantly more likely to develop gambling problems. Those who screened positive as predominantly inattentive and those who screened positive for ADHD Combined (Inattention and Hyperactivity–Impulsivity) were equally likely to gamble, but the latter were twice as likely to have gambling problems. However, we found no significant interaction between the key ADHD symptoms and gambling as the severity of hyperactivity–impulsivity or inattention did not significantly differ with respect to gambling pathology. Emotional problems and depressive affect were the only variables that could significantly differentiate the ADHD types and gambling severity. Our Results highlight the clinical importance of considering the subtype of ADHD among gamblers and the greater association of depressive affect and emotional problems with gambling among adolescents.     

Transnational aging careers: on transformation of kinship and citizenship in the context of migration among Bulgarian Muslims in Spain

This article focuses on “transnational aging careers,” a group of elderly migrants who are in constant movement between social contexts, families, and states. Drawing on a case of Bulgarian Muslim migrants in Spain, I look into the ruptures in the structure of care arrangements, kin expectations, and family relations, which migration triggers. I suggest that these transformations, albeit subtle, lead to reformulation of the fabric of the family. In this way, transnational care-motivated mobility affects future security based on kin reciprocity. At the same time, migration disrupts aging careers’ social citizenship both in Bulgaria and in Spain by limiting or even excluding them from state welfare support. I argue that these two lines of transformation, kinship and citizenship, result in new forms of gender and intergenerational inequalities. Furthermore, their intersection leads to a move from welfare to kinfare, which not only affects present arrangements between migrants, but also entails future insecurities.     

Problem Gambling in Adolescents: An Examination of the Pathways Model

This research tests the applicability of the Integrated Pathways Model for gambling to adolescent problem gamblers, utilizing a cross-sectional design and self-report questionnaires. Although the overall sample consisted of 1,133 adolescents (Quebec: n = 994, 87.7 %; Ontario: n = 139, 12.3 %: Male = 558, 49.5 %; Female = 569, 50.5 %), only problem gamblers were retained in testing the model (N = 109). Personality and clinical features were assessed using the Millon Adolescent Clinical Inventory, attention deficit hyperactivity (ADHD) using the Conners–Wells’ Adolescent Self-Report Scale, and the DSM-IV-MR-J and Gambling Activities Questionnaire to determine gambling severity and reasons for gambling. Latent class analysis concluded 5 classes, yet still provided preliminary support for three distinct subgroups similar to those proposed by the Pathways Model, adding a depression only subtype, and a subtype of problem gamblers experiencing both internalizing and externalizing disorders. ADHD symptoms were found to be common to 4 of the 5 classes.     

Reducing Surgical Ward Congestion Through Improved Surgical Scheduling and Uncapacitated Simulation

High surgical bed occupancy levels often result in heightened staff stress, frequent surgical cancellations, and long surgical wait times. This congestion is in part attributable to surgical scheduling practices, which often focus on the efficient use of operating rooms but ignore resulting downstream bed utilization. This paper describes a transparent and portable approach to improve scheduling practices, which combines a Monte Carlo simulation model and a mixed integer programming (MIP) model. For a specified surgical schedule, the simulation samples from historical case records and predicts bed requirements assuming no resource constraints. The MIP model complements the simulation model by scheduling both surgeon blocks and patient types to reduce peak bed occupancies. Scheduling guidelines were developed from the optimized schedules to provide surgical planners with a simple and implementable alternative to the MIP model. This approach has been tested and delivered to planners in a health authority in British Columbia, Canada. The models have been used to propose new surgical schedules and to evaluate the impact of proposed system changes on ward congestion.     

Trust and Information Sharing in Supply Chains

Drawing on behavioral research, we construct a multi‐period model with which to examine the role of trust and other social characteristics in a supply chain. Specifically, we focus on trust building in the context of a salesperson who acts as a representative of a manufacturer and shares demand forecast information with a retailer. The actions of the salesperson affect both her immediate economic gain and her future credibility as determined by retailer's trust. Our analysis reveals that, in such environments, although salespersons of widely varying types (e.g., honest, self‐serving, benevolent, loyal) lie some extent about their forecast information, they tend to be trusted in long relationships, provided their forecasting accuracy is higher than that of the retailer. Furthermore, while the presence of a salesperson can improve the profits of both the retailer and manufacturer, there are cost structures under which the manufacturer is better off without a salesperson. Finally, we make the general observation that the appropriate salesperson compensation scheme depends on her social characteristics, and the specific observation that when the salesperson cares for the retailer, the linear compensation scheme commonly suggested in the literature as the optimal compensation scheme for the salesperson is no longer optimal.