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991.
A statistical application to Gene Set Enrichment Analysis implies calculating the distribution of the maximum of a certain Gaussian process, which is a modification of the standard Brownian bridge. Using the transformation into a boundary crossing problem for the Brownian motion and a piecewise linear boundary, it is proved that the desired distribution can be approximated by an n-dimensional Gaussian integral. Fast approximations are defined and validated by Monte Carlo simulation. The performance of the method for the genomics application is discussed.  相似文献   
992.
This study examines the effects of out-migration on social capital in sending communities. I first conceptualise social capital as the presence of social trust and engagement at the individual-level of analysis. Drawing from established theories of cooperation, I then argue that subnational out-migration acts as a structural-level signal that changes people’s incentives to trust others and engage in social activities. I use the current migration crisis in Bulgaria to test this argument. Findings from multi-level models that combine cross-sectional survey data and subnational migration flows indicate that high out-migration is correlated with lower levels of generalised trust. Out-migration is also associated with higher frequencies of informal social engagement, indicating that people rely more on their immediate social networks in environments of heavy out-migration. The overall evidence suggests that out-migration is a threat to social capital in sending communities.  相似文献   
993.
994.
People can reliably distinguish the sex of faces across age groups. Rates of accuracy are lower for infants, however, likely because they lack the pronounced sexually dimorphic features that develop during puberty. Given that previous research has shown that perceivers categorize adult sex automatically, we wondered whether this would extend to the faces of infants for whom sex is less legible. We tested this using a semantic priming paradigm in which infant faces preceded the categorization of stereotypically male and female names. Results showed that participants categorized the sex of male names significantly faster following perceptions of male versus female infant faces (though female faces did not significantly facilitate the processing of female names). The asymmetry in interference for male but not female faces supports evidence for a male default in conceptions of sex among infants previously found for adults. Individuals may therefore process sex automatically in the absence of overt cues (e.g., post-pubertal sexually dimorphic features or stereotypical clothing), providing additional evidence for the depth and flexibility of social categorization.  相似文献   
995.
The study explored whether sibling affection and hostility were longitudinally associated with adolescents' prosocial, externalizing, and depressive behaviors, after controlling for parent–child and best friend relationship quality. Sympathy was examined as a possible mediator. Three hundred and eight randomly selected families completed Waves 3, 4, and 5 of the Flourishing Families Project. Multiple group comparison via structural equation modeling compared differences between girls and boys. Sibling affection (T3) was positively associated with adolescents' sympathy (T4) and prosocial behavior (T5). Sibling hostility (T3) was positively associated with adolescents' depression (T5) and externalizing behavior (T5) (for boys only), even after controlling for parent and friend relationships. Discussion focuses on the unique role of the sibling relationship on adolescent development.  相似文献   
996.
In this article, I argue that, despite the myth of gay affluence, existing research is conclusive enough to claim that lesbian, gay, bisexual, and transgender (LGBT) adults are overall less financially secure than their heterosexual, cisgendered counterparts. I demonstrate that LGBT poverty is a broad social issue that can no longer be viewed as affecting only specific subpopulations of LGBT communities. I argue that the social work profession and the LGBT movement need to recognize LGBT poverty as a social issue. I then present a call to action for social work practitioners, researchers and LGBT organizations.  相似文献   
997.
ABSTRACT

Americans view adoption favorably, yet few consider adopting or actually adopt a child. Using qualitative data from the representative National Survey of Fertility Barriers, we explored why women who had considered adoption decided not to pursue it as a pathway to parenthood. Our sample includes responses from 1,747 women who considered adoption at some point. Seven themes emerged: prioritization of biology, economic concerns, family building prerequisites, relationship barriers, barriers to adoption, family barriers, and change of heart. Findings highlight that barriers to adoption are not always the primary reasons women opt out of adoption; normative conceptualizations of “family” are also important.  相似文献   
998.
During the last year the amount of refugees and asylum seekers has increased tremendously all over the world. Many refugees arrived in Germany asking for help and integration. Politicians were challenged to offer educational programs in particular for the young, (un-) accompanied minors. In Bavaria an extensive vocational education program has been developed and started to be established under tremendous time pressure. However, the implementation process challenges government officials, principals, teachers as well as social workers. Results of our Delphi-Study confirm that these groups of agents had to deal with many problems, but also perceive great opportunities. In this paper chances and problems of implementing this vocational education program all over Bavaria are discussed in the light of organizational approaches. The results show that typical phases of unfreezing, moving and refreezing emerged simultaneously. Currently, we see many indicators of the moving phase and some of the refreezing phase. However, it is not possible to predict the end of the refreezing phase.  相似文献   
999.
Opioid abuse is a growing and significant public health concern in the United States. Naloxone is an opioid antagonist that can rapidly reverse the respiratory depression associated with opioid toxicity. Georgetown University's collegiate-based emergency medical services (EMS) agency recently adopted a protocol, allowing providers to administer intranasal naloxone for patients with suspected opioid overdose. While normally not within the scope of practice of basic life support prehospital agencies, the recognition of an increasing epidemic of opioid abuse has led many states, including the District of Columbia, to expand access to naloxone for prehospital providers of all levels of training. In particular, intranasal naloxone is a method of administering this medication that potentially avoids needlestick injuries among EMS providers. Universities with collegiate-based EMS agencies are well positioned to provide life-saving treatments for patients acutely ill from opioid overdose.  相似文献   
1000.
Effective delivery of services for the public good involves a multiplicity of organizations and actors, including those from the public, nonprofit, and private sectors. In some cases, service delivery is accomplished using programs that directly engage volunteers, including key public services like community-based and nonprofit volunteer fire departments. Volunteers in fire departments—often highly engaged volunteers with specialized training—provide vital services for a substantial portion of the United States, allowing local governments to realize considerable cost savings. Thus, issues of volunteer retention are a critical challenge for fire departments. Existing research has addressed issues of retention in a variety of settings; we argue that the challenging and particular context of fire departments is worthy of focused research. This article is an exploratory study of the predictors of voluntary firefighter retention in the Commonwealth of Pennsylvania. We use data from a web-based survey of volunteer firefighters to examine the factors that influence volunteer retention, focusing specifically on volunteer management practices and broader job-related concepts. Results indicate that volunteer training, performance management, job satisfaction, and organizational commitment influence both short- and mid-term intent to remain, indicating that management practices and programs, as well as other contextual factors that shape satisfaction and commitment, are important in retaining volunteers.  相似文献   
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