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71.
Francois Mercier Nicola Consalvo Nicolas Frey Alex Phipps Benjamin Ribba 《Pharmaceutical statistics》2019,18(5):526-532
Waterfall plots are used to describe changes in tumor size observed in clinical studies. They are frequently used to illustrate the overall drug response in oncology clinical trials because of its simple representation of results. Unfortunately, this visual display suffers a number of limitations including (1) potential misguidance by masking the time dynamics of tumor size, (2) ambiguous labelling of the y‐axis, and (3) low data‐to‐ink ratio. We offer some alternatives to address these shortcomings and recommend moving away from waterfall plots to the benefit of plots showing the individual time profiles of sum of lesion diameters (according to RECIST). The spider plot presents the individual changes in tumor measurements over time relative to baseline tumor burden. Baseline tumor size is a well‐known confounding factor of drug effect which has to be accounted for when analyzing data in early clinical trials. While spider plots are conveniently correct for baseline tumor size, they cannot be presented in isolation. Indeed, percentage change from baseline has suboptimal statistical properties (including skewed distribution) and can be overly optimistic in favor of drug efficacy. We argued that plots of raw data (referred to as spaghetti plots) should always accompany spider plots to provide an equipoised illustration of the drug effect on lesion diameters. 相似文献
72.
Nicolas Graham 《Revue canadienne de sociologie》2019,56(2):224-250
This study investigates the relationship between the carbon extractive sector in Canada and renewable energy development. Specifically, it examines the strategies employed by Canadian carbon‐capital firms to shape and control alternative energy and considers if we are witnessing signs of “transition capture” as some oil, gas, and coal firms invest in a gradual shift toward “climate capitalism.” I investigate first, investments by large Canada‐based fossil fuel companies in renewable energy and second, interlocking directorate relations between the fossil fuel sector and the renewables industry. Findings suggest the possibility of a long‐term strategic orientation toward a climate capitalist model of development by some carbon‐capital firms; however, this alignment remains highly tentative, with evidence pointing to an industry that is largely without plans for energy transition. 相似文献
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75.
The present communication deals with the methodology of the ergonomics field intervention process. It proposes an operationalized version of work analysis in terms of contradictions. The aim is to demonstrate that such a dialectic tool and method of representation may assist the ergonomist to frame the essence of a work activity in practical terms, swiftly and in a manner that preserves its multifaceted unity. The proposed method is inspired by two theoretical constructs (i) contradiction as used in Cultural Historical Activity Theory and (ii) regulation, as developed and used by the francophone tradition of ergonomics of activity. Two brief examples of its use are presented and a discussion is made on further developments and possible pitfalls. 相似文献
76.
Millions of people with print disabilities are denied the right to read. While some important efforts have been made to convert standard books to accessible formats and create accessible repositories, these have so far only addressed this crisis in an ad hoc way. This article argues that universally designed ebook libraries have the potential of substantially enabling persons with print disabilities. As a case study of what is possible, we analyse 12 academic ebook libraries to map their levels of accessibility. The positive results from this study indicate that universally designed ebooks are more than possible; they exist. While results are positive, however, we also found that most ebook libraries have some features that frustrate full accessibility, and some ebook libraries present critical barriers for people with disabilities. Based on these findings, we consider that some combination of private pressure and public law is both possible and necessary to advance the right-to-read cause. With access improving and recent advances in international law, now is the time to push for universal design and equality. 相似文献
77.
‘The status quo is not an option’: Community impacts of school closure in South Taranaki,New Zealand 总被引:1,自引:0,他引:1
This paper explores the impacts of proposed school closures on families in rural communities in the South Taranaki region of New Zealand. We situate this instance of educational restructuring in a critical policy context and present an account of its regional unfolding through drawing on local media coverage. We then interpret narratives gathered during an interview-based study of the proposed changes undertaken in 2003–2004. Our analysis highlights the impact of school closure for rural settlements in terms of affect as well as effects. More generally we reflect on the place of schools in the experience of place itself, as well as their contribution to social cohesion and the broadly defined health of a community. 相似文献
78.
Nicolas Pistolesi 《Journal of Economic Inequality》2009,7(4):411-433
We measure inequality of opportunity for earnings acquisition in the U.S. between 1968 and 2001. Following recent theories
of social justice, earnings determinants are divided into two parts: Circumstances, which are characteristics outside individual control and effort representing factors impacting earnings but under individuals’ responsibility. Equality of opportunity requires that inequality
of circumstances must be corrected while differences of effort must remain unaltered. Circumstances are represented by parental
education and occupation, ethnic origin, place of birth and age. Effort is modeled with schooling choices and labour supply
decisions. Using the PSID from 1968 to 2001, we provide two alternative assessments of inequality of opportunity using counterfactual
distributions. The statistical framework is semi-parametric and builds on duration models. Finally, we conclude that inequality
of opportunity represents between 20 and 43% of earnings inequality, but decreases all over the period reaching around 18%
in 2001. 相似文献
79.
Given a network G=(V,E), we say that a subset of vertices S⊆V has radius r if it is spanned by a tree of depth at most r. We are interested in determining whether G has a cutset that can be written as the union of k sets of radius r. This generalizes the notion of k-vertex connectivity, since in the special case r=0, a set spanned by a tree of depth at most r is a single vertex. 相似文献
80.
ABSTRACTFutures of mobility are a pressing concern for cities addressing sustainability and climate change challenges. As cities renew their mobility systems and launch efforts to meet these targets, new sensitive qualitative methodologies are needed. This article discusses a focused mobility diary experiment that was conducted in May 2017 in Turku, Finland and its subarea, with a small set of participants. The goal of this study was to gain insights into potential developments in the city’s mobility systems and practices. This article utilises a multidisciplinary complex systems approach describing how we used the concepts of futures signals and mobile utopias as tools when analysing some prefigurative patterns in individual mobility practices. A key outcome of this methodological experimentation was the interconnections made between two research traditions and a notion of the various ways care underlies, effects, and contours the mobility practices of people–in other words, people are moved by care. This article demonstrates how with the concepts of futures signals, and mobilised utopias, we can reach the important aspirational and prefigurative practices and motivations of people, which permit us to interpret potential futures in particular urban settings characterised by daily life activities. 相似文献