Practical usage of O'Brien's OLS and GLS statistics in clinical trials

Multivariate techniques of O'Brien's OLS and GLS statistics are discussed in the context of their application in clinical trials. We introduce the concept of an operational effect size and illustrate its use to evaluate power. An extension describing how to handle covariates and missing data is developed in the context of Mixed models. This extension allowing adjustment for covariates is easily programmed in any statistical package including SAS. Monte Carlo simulation is used for a number of different sample sizes to compare the actual size and power of the tests based on O'Brien's OLS and GLS statistics.     

Exploring Risk Judgments in a Trade Dispute Using Bayesian Networks

Bayesian networks (BNs) are graphical modeling tools that are generally recommended for exploring what‐if scenarios, visualizing systems and problems, and for communication between stakeholders during decision making. In this article, we investigate their potential for exploring different perspectives in trade disputes. To do so, we draw on a specific case study that was arbitrated by the World Trade Organization (WTO): the Australia‐New Zealand apples dispute. The dispute centered on disagreement about judgments contained within Australia's 2006 import risk analysis (IRA). We built a range of BNs of increasing complexity that modeled various approaches to undertaking IRAs, from the basic qualitative and semi‐quantitative risk analyses routinely performed in government agencies, to the more complex quantitative simulation undertaken by Australia in the apples dispute. We found the BNs useful for exploring disagreements under uncertainty because they are probabilistic and transparently represent steps in the analysis. Different scenarios and evidence can easily be entered. Specifically, we explore the sensitivity of the risk output to different judgments (particularly volume of trade). Thus, we explore how BNs could usefully aid WTO dispute settlement. We conclude that BNs are preferable to basic qualitative and semi‐quantitative risk analyses because they offer an accessible interface and are mathematically sound. However, most current BN modeling tools are limited compared with complex simulations, as was used in the 2006 apples IRA. Although complex simulations may be more accurate, they are a black box for stakeholders. BNs have the potential to be a transparent aid to complex decision making, but they are currently computationally limited. Recent technological software developments are promising.     

Exploring the Impact of School Discipline on Racial Disproportion in the Juvenile Justice System*

It is widely recognized that African‐American youth are significantly overrepresented in many juvenile justice systems relative to their population percentages. Research has also determined that similar disproportion exists in school discipline and speculated about a “school‐to‐prison pipeline” for minority youth. Objective. This study explores empirically the degree to which disciplinary decisions made in schools can help to explain observed rates of disproportionate minority contact with juvenile courts. Methods. It does so in an assessment of education and justice system data from a sample of counties in Missouri. Results. The findings suggest that racial disproportion in out‐of‐school suspensions, which cannot be explained solely by differences in delinquent behavior, is strongly associated with similar levels of disproportion in juvenile court referrals. The association between disproportionate patterns of school discipline and court referrals persists after controlling for poverty, urbanization, and other relevant factors. Conclusions. The implication is that school‐based programs that offer alternatives to suspension and expulsion and promote disciplinary equity may help alleviate racial disproportion in the juvenile justice system.     

St Christopher's and the future

The founding vision of St Christopher's Hospice was based on a recognition that permeating mainstream health care services would be essential and an emphasis on an adaptable philosophy rather than a building. Today, demographic and disease related changes mean that need and demand for end-of-life care will inevitably outstrip professional and financial resource. Hospices must engage with the development of cost-effective models of service delivery and rational planning. Only partnership working with the National Health Service, care homes, and others will ensure that appropriate care is available to everyone wherever the bed in which they die, regardless of diagnosis. Only collaboration and active engagement will ensure that future strategy in end-of-life care retains the original insight that its focus rightly includes not only patients but also the social context that will be affected by their death. Cost and patient choice dictate an emphasis on care at home. Health-promoting, public education and family-focused strategies will be essential. At a pivotal moment for the delivery of health care generally, hospices can play a vital part by marrying the role of "insistent conscience" of the health care service with continued cost-effective clinical innovation.     

User satisfaction and user experiences with Access Grid as a medium for social science research: a research note

Access Grid (AG) is a state-of-the-art video conferencing system that operates over computer networks such as the Internet. In the research sphere it has principally been used to conduct meetings of natural scientists in large international collaborations, such as physicists collaborating over the Large Hadron Collider. Social scientists have recently begun exploring the use of AG to conduct ‘virtual fieldwork' where researchers carry out interviews or moderate group discussions involving participants at remote sites. There have also been experiments in using AG to deliver social research methods training and to facilitate meetings between social researchers and government researchers who are collaborating on research projects. This article provides a quantitative analysis of the experiences of a sample of participants in such AG sessions. It finds a high degree of satisfaction with the technical affordances of the medium, and identifies differences in perspective according to whether a session is research-oriented or has a ‘real world' purpose.     

Howard Caygill on resistance: ecce homo

Howard Caygill’s On Resistance (2013) is changing the landscape of how the concept of resistance is understood. In his book, he theorises a concept of resistance rooted in the Kantian aporia of judgement, in the Hegelian notion of Force, in Clausewitz’s idea of resistance as a capacity and in the Nietzschean notion of affirmation. He employs these against philosophies of dialectic and resolution. I trace these themes back through some of his earlier work, to reveal the tensions that persist in his own thinking, and which underpin the puzzles, the aporias, that are central to his notion of resistance. I argue that in his earlier work a notion of (Hegelian) philosophical education receives more generous treatment. By retrieving this notion of learning and locating it within On Resistance, we can get closer not only to the relationship between actuality, possibility and necessity, that are so important to Caygill’s notion of resistance, but also to the philosophical character of the man Caygill: ecce homo.