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Dairies within the United Kingdom are classified into two groups, namely, off-farm and on-farm dairies (the latter often being small scale). We propose a model for the probability of milk sold as pasteurized reaching the point of retail contaminated with Vero-cytotoxigenic Escherichia coli (VTEC) O157 from each of these two pathways. We evaluate qualitatively the exposures inherent in each, and compare and contrast the two situations. The model framework is generic, in that it can in principle be used, with the relevant data modifications, to provide a qualitative assessment of the likely exposure from milk sold as pasteurized to any potentially milk-borne pathogenic organism. Furthermore, the methodological approaches presented are widely applicable in the microbial risk assessment field. The specific example presented will be of particular interest to the UK dairy and public health communities: we conclude that the exposure potential per liter consumed from milk processed in off-farm dairies is negligible, whereas the exposure potential per liter consumed from milk processed on-farm is low, but not sufficiently small to be regarded as negligible. We also identify areas of data sparsity, which need to be addressed for quantitative risk assessment to proceed, and highlight the critical points in the pasteurized milk production chain, which, in the event of a breakdown, have the potential to increase the risk to the consumer.  相似文献   
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Book reviewed in this article: Region North America: Canada, United States, Mexico. Proceedings. Edited by Glen E. Lich and Joseph A. McKinney Undocumented Mexicans in the United States. By David M. Heer  相似文献   
158.

Background

About 30% of women in labour suffer from lower back pain. Studies of sterile water injections for management of low back pain have consistently shown this approach to be effective. The objective of this evidence-based guide is to facilitate the clinical use of sterile water injections to relieve lower back pain in labouring women.

Methods

To identify relevant publications our search strategy was based on computerised literature searches in scientific databases. The methodological quality of each study was assessed using the modified version of the Jadad scale, 12 studies were included.

Findings

Recommendations regarding the clinical use of sterile water injections for pain relief in labour are reported in terms of the location of injection administration, various injection techniques, number of injections used, amount of sterile water in each injection and adverse effects.

Discussion

Both injection techniques provide good pain relief for lower back pain during labour. The subcutaneous injection technique is possibly less painful than the intracutaneous technique administered, but we are unsure if this impacts on effectiveness. The effect seems to be related to the number of injections and the amount of sterile water in each injection.

Conclusion

The recommendation at present, based on the current state of knowledge, is to give four injections. Notwithstanding the differences in injection technique and number of injections the method appears to provide significant levels of pain relief and can be repeated as often as required with no adverse effect (apart from the administration pain) on the woman or her foetus.  相似文献   
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What is the significance of “regional policy” in Europe today? It is certainly a political force. It was a major factor in the resignation of General de Gaulle last year and a European Conference of Ministers of Regional Planning is being convened to consider it this year. But as a subject it is not always easy to grasp. It seems to touch on many things-environment, employment, democratic participation and long range planning. Its actual shape varies from country to country. At the same time, many Europeans, including the Commission of the European Communities, are convinced that there are common European problems that urgently require a European regional policy to solve them. This article, which will be in four parts, begins by examining the experience of regional policy in the UK, France, Italy, Germany and the European Communities. Its last part will discuss the role of long range planning in achieving an effective regional policy at European level. The author is carrying out research into regional policies in the European Communities and the United Kingdom with financial support from the Social Science Research Council.  相似文献   
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