Bioactive compounds of the Mediterranean diet and prostate cancer

Abstract

Objective: The purpose of this review is to examine the evidence on the effects of bioactive constituents of the Mediterranean diet (MeDi) on prostate cancer (PCa) risk.

Methods: The search for articles came from extensive research in the following databases: PubMed, Scopus, and Web of Science. We used the search terms “Mediterranean diet,” “lycopene,” “vitamin E,” “vitamin C,” “Selenium,” “resveratrol,” “prostate cancer,” and combinations, such as “lycopene and prostate cancer” or “resveratrol and prostate cancer.”

Results: Numerous studies investigating the effect of various dietary nutrients on PCa have suggested that selenium is probably the most promising. Several studies reported reduced PCa risk associated with vitamin C and E intake, while other studies reported no association. Lycopene inhibits cell proliferation and inducts apoptosis, thus protecting against cancer. Also, it has been found in various in vivo and in vitro studies that resveratrol, inhibits PCa development.

Conclusions: The high content of bioactive phytochemicals in the MeDi is of particular interest in the prevention of PCa. Further large-scale studies are required to clarify the effect of MeDi bioactive compounds on prostate health, in order to establish the role of this diet in the prevention of PCa.     

High Performance Work Practices and Firm Performance: A Longitudinal Case Study

Accumulating research suggests that the adoption of high performance work practices (HPWPs) is related to organizations' performance. The evidence base is limited by its reliance on retrospective survey reports. This study uses an intervention, including longitudinal interview and survey reports, of the implementation and outcomes of the introduction of HPWPs alongside time series data of objective performance metrics recorded before and after the intervention. The results showed that the implementation of HPWPs was associated with subsequent and sustained increases in productivity and safety performance. The study suggests that a specifically designed intervention involving HPWPs can have beneficial effects both on productivity and safety, but other intermediary variables associated with the implementation process may be critical in mitigating potentially detrimental worker welfare effects arising from work intensification.     

City-wide relationships between green spaces,urban land use and topography

The growing proportion of human populations living in urban areas, and consequent trends of increasing urban expansion and densification fuel a need to understand how urban form and land use affect environmental quality, including the availability of urban green spaces. Here we use Sheffield as a case study of city-wide relationships between urban green space extent, quality (vegetation cover and tree-cover), and gradients in urban form and topography. The total area of buildings and length of the road network are equally strong negative predictors of extent of green space, while the former predictor is a more important negative influence upon green space quality. Elevation positively influences extent of green space but negatively influences tree-cover. In contrast, slope of terrain positively influences green space quality and is the best predictor of tree-cover. Overall housing density is a more important negative predictor of extent of green space and tree-cover than the densities of individual housing types. Nevertheless, the latter are more important influences upon levels of vegetation cover. Threshold effects of densities of different housing types suggest opportunities for optimising green space quality, with implications for housing policy. Variation in ecological quality of green space may partly reflect different historical intensities of industrial activity.     

Asylum‐seeking minors in interpreter‐mediated interviews: what do they say and what happens to their responses?

This study explored how asylum‐seeking minors report information when formally interviewed. Twenty‐six Russian‐speaking minors (mean = 16.0 years of age) were individually interviewed by officials assisted by one of 18 interpreters. A qualitative analysis of the responses was used to develop categories that were then analysed quantitatively to elucidate characteristics of the questions asked by the officials, the minors' responses to them and the accuracy with which the minors' responses were rendered. The asylum‐seeking minors distinguished themselves as active participants. They appeared eager to disclose relevant information despite being asked many potentially contaminating questions. Most of the children's responses were accurately rendered, but mistranslations can affect the fact‐finding process substantially. Both the minors and the officials involved in the asylum‐seeking process need to recognize that both the questions asked and the responses given may be influenced by the third parties involved, i.e. the interpreters.     

Tests for Equality of Survival Distributions Against Non-Location Alternatives

We propose new two andk-sample tests for evaluating the equality of survival distributions against alternatives that include crossing of survival functions, and proportional and monotone hazard ratios. The tests allow for right censored data. The asymptotic power against local alternatives is investigated. Simulation results demonstrate that the new tests are more powerful than known tests when survival functions cross. We apply the tests to a well known study of chemo- and radio-therapy conducted by the Gastrointestinal Tumor Study Group. TheP-values for both proposed tests are much smaller than for other known tests.     

On Measuring Segregation in a Multigroup Context: Standardized Versus Unstandardized Indices

Social Indicators Research - There has been little discussion about the consequences of using standardized, rather than unstandardized, segregation measures when comparing societies with different...     

The Jewish Museum and Tolerance Center in Moscow: Judaism for the masses

In 2012, a new Jewish Museum and Tolerance Center opened in Moscow – an event unthinkable during the Soviet regime. Financed at the level of $50 million, created by an international crew of academics and museum designers, and located in a landmark building, the museum immediately rose to a position of cultural prominence in the Russian museum scene. Using interactive technology and multimedia, the museum's core exhibition presents several centuries of complex local Jewish history, including the Second World War period. Naturally, the Holocaust is an important part of the story. Olga Gershenson's essay analyzes the museum's relationship to Holocaust history and memory in the post-Soviet context. She describes the museum's struggle to reconcile a Soviet understanding of the “Great Patriotic War” with a dominant Western narrative of the Holocaust, while also bringing the Holocaust in the Soviet Union to a broader audience via the museum. Through recorded testimonies, period documents, and film, the museum's display narrates the events of the Holocaust on Soviet soil. This is a significant revision of the Soviet-era discourse, which universalized and externalized the Holocaust. But this important revision is limited by the museum's choice to avoid the subject of local collaborators and bystanders. The museum shies away from the most pernicious aspect of the Holocaust history on Soviet soil, missing an opportunity to take historic responsibility and confront the difficult past.