A generalized scheffé method of multiple comparisons

Standard resulrs on the extrema of quotients of quadratic forms are extended to the non-negative definite case. The maximum and the set over which it is achieved are characterized explicitly both in terms of generalized inverse matrices and generalized eigenvalues. These results become the basis of Scheffe type multiple comparisons in the usual way. To demonstrate their application to statistics with singular covariance matrices, the method is detailed for Mantel-Haenszel, Breslow, and Cox statistics. An example is presented illustrating a situation where the proposed Scheffe type comparisons may be better than the pairwise method.     

Multicollinearity and the value of a priori information

A measure of multicollinearity is defined which is useful in evaluating maintained hypotheses and aiding estimator selection as it suggests when a non-traditional estimator proposed by Bock (1975) is minimax and dominates ordinary least squares. An example is used to illustrate the presented methodology.     

An experimenter’s view of the application of statistics to cloud-seeding experiments

An experimenter in the field of cloud seeding describes aspects of experiments which he would like statisticians to take into account and suggects Problems which he would like statisficians solve.     

Time series analysis of stratospheric ozone

Time series analyses of monthly average total ozone measured at 37 stations throughout the world were used to estimate the extent to which the average ozone trend correlates with the depletion curve hypothesized as due to chlorofluorocarbons (CFCs). Statistical characteristics of stations in the ensemble were used to help define appropriate model and station selection criteria. The maximum likelihood procedure developed herein estimates the weighted average trend, its. variance, and the intra- and inter-station variance components of the trend. Correlations among trends at different stations are also taken into account. The models were subjected to much checking and criticism. Variations in statistical methodology are used to show that the results are insensitive to details of the model selection criteria. The method does not discriminate well between the hypothesized CFC trend and a linear trend. The trend estimates represent the sum of all long-term global effects. The variance includes all effects that differ from station-to-station. The estimated trend and 2α limits for 14 stations with 20-year records (1958-79) is an ozone increase through 1979 of (1.5+1.0) percent. At the 23 stations with shorter records, the trend is (1.0=1.7) percent. It is concluded that no significant depletion in stratospheric ozone has occurred from any cause through the end of 1979.     

Standard and goodness-of-fit parameter estimation methods for the three-parameter lognormal distribution

A class of goodness-of-fit estimators is found to provide a useful alternative in certain situations to the standard maximum likelihood method which has some undesirable estimation characteristics for estimation from the three-parameter lognormal distribution. The class of goodness-of-fit tests considered include the Shapiro-Wilk and Filliben tests which reduce to a weighted linear combination of the order statistics that can be maximized in estimation problems. The weighted order statistic estimators are compared to the standard procedures in Monte Carlo simulations. Robustness of the procedures are examined and example data sets analyzed.     

Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.