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31.
    
  相似文献   
32.
    
In this article, we present a general model to deal with the problem of matching multiple objects or configurations of points from a Bayesian point of view. We study both labeled and non labeled cases. Our model generalizes, in terms of non singular affine transformations and multiple configurations, previous two-terms matching models. As a practical application in Bioinformatics, we consider data from a microarray experiment of gorilla, bonobo, and human-cultured fibroblasts. We find out the matchings and the best affine transformation between the projections of genes on a two-dimensional space, obtained by a multidimensional scaling technique.  相似文献   
33.
    
We consider regularizations by convolution of the empirical process and study the asymptotic behaviour of non-linear functionals of this process. Using a result for the same type of non-linear functionals of the Brownian bridge, shown in a previous paper [4], and a strong approximation theorem, we prove several results for the p-deviation in estimation of the derivatives of the density. We also study the asymptotic behaviour of the number of crossings of the smoothed empirical process defined by Yukich [17] and of a modified version of the Kullback deviation.  相似文献   
34.
    
A new discrete family of probability distributions that are generated by the 3 F 2 function with complex parameters is presented. Some of the properties of this new family are studied as well as methods of estimation for its parameters. It affords considerable flexibility of shape which turns the distribution into an appropriate candidate for modeling data that cannot be adequately fitted by classical families with fewer parameters. Finally, three examples in the fields of Agriculture and Education are included in order to show the versatility and utility of this distribution.  相似文献   
35.
    
We propose a new method to estimate the cumulative hazard function and the corresponding distribution function of survival times under randomly left-truncated and right-censored observations (LTRC). The new estimators are based on presmoothing ideas, the estimation of the conditional expectation m of the censoring indicator. An almost sure representation for both estimators is established, from which a strong consistency rate and asymptotic normality are derived. It is shown that the presmoothed modification leads to a gain in terms of asymptotic mean squared error. This efficiency with respect to the classical estimators is also shown in a simulation study. Finally, an application to a real data set is provided.  相似文献   
36.
    
It is common to fit generalized linear models with binomial and Poisson responses, where the data show a variability that is greater than the theoretical variability assumed by the model. This phenomenon, known as overdispersion, may spoil inferences about the model by considering significant parameters associated with variables that have no significant effect on the dependent variable. This paper explains some methods to detect overdispersion and presents and evaluates three well-known methodologies that have shown their usefulness in correcting this problem, using random mean models, quasi-likelihood methods and a double exponential family. In addition, it proposes some new Bayesian model extensions that have proved their usefulness in correcting the overdispersion problem. Finally, using the information provided by the National Demographic and Health Survey 2005, the departmental factors that have an influence on the mortality of children under 5 years and female postnatal period screening are determined. Based on the results, extensions that generalize some of the aforementioned models are also proposed, and their use is motivated by the data set under study. The results conclude that the proposed overdispersion models provide a better statistical fit of the data.  相似文献   
37.
    
Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail.  相似文献   
38.
    
A model for the assessment of exposure to Listeria monocytogenes from cold-smoked salmon consumption in France was presented in the first of this pair of articles (Pouillot et al ., 2007, Risk Analysis, 27:683–700). In the present study, the exposure model output was combined with an internationally accepted hazard characterization model, adapted to the French situation, to assess the risk of invasive listeriosis from cold-smoked salmon consumption in France in a second-order Monte Carlo simulation framework. The annual number of cases of invasive listeriosis due to cold-smoked salmon consumption in France is estimated to be 307, with a very large credible interval ([10; 12,453]), reflecting data uncertainty. This uncertainty is mainly associated with the dose-response model. Despite the significant uncertainty associated with the predictions, this model provides a scientific base for risk managers and food business operators to manage the risk linked to cold-smoked salmon contaminated with L. monocytogenes. Under the modeling assumptions, risk would be efficiently reduced through a decrease in the prevalence of L. monocytogenes or better control of the last steps of the cold chain (shorter and/or colder storage during the consumer step), whereas reduction of the initial contamination levels of the contaminated products and improvement in the first steps of the cold chain do not seem to be promising strategies. An attempt to apply the recent risk-based concept of FSO (food safety objective) on this example underlines the ambiguity in practical implementation of the risk management metrics and the need for further elaboration on these concepts.  相似文献   
39.
    
The purpose of this study was to examine the viability of hybrid competitive strategies, which combine differentiation and cost elements, and their impact on organizational performance in comparison to pure strategies and ‘stuck‐in‐the‐middle’ combinations. Previous studies have focused above all on US data. The analysis carried out in this paper has centred on a multisectorial sample of 164 Spanish firms. The findings show that a large number of the organizations use different types of hybrid strategies and also that such strategies tend to be associated with higher levels of firm performance, particularly those strategies which place emphasis on a greater number of strategic dimensions, and specifically on innovation differentiation.  相似文献   
40.
    
This paper investigates the effect of linguistic diversity on redistribution in a broad cross‐section of countries. We use the notion of “linguistic distances” and show that the commonly used fractionalization index, which ignores linguistic distances, yields insignificant results. However, once distances between languages are accounted for, linguistic diversity has both a statistically and economically significant effect on redistribution. With an average level of redistribution of 9.5% of GDP in our data set, an increase byone standard deviation in the degree of diversity lowers redistribution by approximately one percentage point. We also demonstrate that other measures, such as polarization and peripheral heterogeneity, provide similar results when linguistic distances are incorporated. (JEL: D6, D74, H5, Z10)  相似文献   
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