EFFECTS OF EXPOSURE ON PREVALENCE AND CUMULATIVE RELATIVE RISK: DIRECT AND INDIRECT EFFECTS IN A RECURSIVE HAZARD MODEL

This paper outlines decomposition methods for assessing how exposure affects prevalence and cumulative relative risk. Let     x     denote a vector of exogenous covariates and suppose that a single dimension of time   t   governs two event processes     T ₁  and   T ₂.    If the occurrence of the event     T ₁    determines entry into the risk of the event     T ₂,    then subgroup variation in     T ₁    will affect the prevalence     T ₂,    even if subgroups in the population are otherwise identical. Although researchers often acknowledge this phenomenon, the literature has not provided procedures to assess the magnitude of an exposure effect of     T ₁    on the prevalence of     T ₂.    We derive decompositions that assess how variation in exposure generated by direct and indirect effects of the covariates     x     affect measures of absolute and relative prevalence of     T ₂.    We employ a parametric but highly flexible specification for baseline hazard for the     T ₁  and   T ₂    processes and use the resulting parametric proportional hazard model to illustrate the direct and indirect effects of family structure when     T ₁    is age at first sexual intercourse and     T ₂    is age at a premarital first birth for data on a cohort of non-hispanic white U.S. women.     

An Empirical Approach to Sufficient Similarity: Combining Exposure Data and Mixtures Toxicology Data

When assessing risks posed by environmental chemical mixtures, whole mixture approaches are preferred to component approaches. When toxicological data on whole mixtures as they occur in the environment are not available, Environmental Protection Agency guidance states that toxicity data from a mixture considered “sufficiently similar” to the environmental mixture can serve as a surrogate. We propose a novel method to examine whether mixtures are sufficiently similar, when exposure data and mixture toxicity study data from at least one representative mixture are available. We define sufficient similarity using equivalence testing methodology comparing the distance between benchmark dose estimates for mixtures in both data‐rich and data‐poor cases. We construct a “similar mixtures risk indicator”(SMRI) (analogous to the hazard index) on sufficiently similar mixtures linking exposure data with mixtures toxicology data. The methods are illustrated using pyrethroid mixtures occurrence data collected in child care centers (CCC) and dose‐response data examining acute neurobehavioral effects of pyrethroid mixtures in rats. Our method shows that the mixtures from 90% of the CCCs were sufficiently similar to the dose‐response study mixture. Using exposure estimates for a hypothetical child, the 95th percentile of the (weighted) SMRI for these sufficiently similar mixtures was 0.20 (i.e., where SMRI <1, less concern; >1, more concern).     

Evaluation of two school‐based HIV prevention interventions in the border city of Tijuana,Mexico

This research project examined the individual and combined effectiveness of an HIV prevention workshop and a free condom distribution program in four high schools in Tijuana, Mexico. Adolescents (N = 320) completed baseline measures on sexual practices and theoretical correlates and participated in a two‐part study. In Study I, students were randomly assigned to an HIV prevention workshop or a control condition, with a 3‐month follow‐up assessment. Results indicate three significant workshop benefits regarding HIV transmission by altering sexual initiation, access to condoms, and traditional beliefs regarding condoms. In Study 2, we set up a condom distribution program at two of the participating schools, and students completed a 6‐month follow‐up assessment. Results indicate that exposure to the workshop followed by access to the condom distribution program yielded two beneficial results for reducing HIV transmission: moderating sexual initiation and increasing condom acquisition. Access to the condom distribution program alone had no effects on behavioral and psy‐chosocial correlates of HFV transmission. We discuss implications of these results.     

Trade, education, and innovation: Prospects for the U.S. economy

This paper examines international trade issues as vital indicators of the economic prospects of the United States and other developed economies. In particular, it challenges misuses of the doctrine of mutual gains from trade and instead argues that comparative advantage does not guarantee increases in benefits to both trading partners—especially when one partner seeks to distort the market mechanism in its favor. In the face of such mercantilist or protectionist practices, efforts to advance innovation, without retaining manufacturing jobs, will not ensure continued prosperity, as the number of jobs entailed in the invention process is small compared with the number of jobs associated with manufacturing an innovative product for mass consumption. These matters call for the urgent rethinking of trade policy by the United States and other developed nations, if they are to balance their imports and exports and ensure continued economic growth.     

Projektmanagement mit virtuellen Teams?

Globalisation and internationalisation of organisations as well as fast-paced development of modern electronic communication technologies require and support the implementation of globally distributed project teams. Members are working together in different locations and in different time zones. These facts have an impact on project work. This article tries to critically reflect the work of virtual project teams and it tries to answer the question, if we can speak about teamwork under such circumstances.     

Sex,Arts and Verbal Abilities: Three Further Indicators of How American Life is not Improving

Despite clear evidence that Americans’ economic standard of living has improved over the last half-century in terms of income, ownership of technology and housing among other indicators, there is scant evidence from non-economic quality-of-life (QOL) indicators of improved life quality to parallel these economic gains. The present article adds to this list in showing little if any progress in three QOL indicators (the first two about time and activity) that have received less or no attention in the social indicators literature, namely (1) frequency of the highly enjoyable activity of sex, (2) participation in various serious arts activities and (3) scores of verbal ability. The data on sexual activity and verbal ability come from the 1974–2008 General Social Surveys (GSS) from the University of Chicago, and for the arts from the 2008 Survey of Public Participation in the Arts (SPPA) conducted by the US Census Bureau for the National Endowment for the Arts since 1982. All three surveys interviewed nationally representative samples, with over 70% response rates and sample sizes of more than 15,000 adults. The GSS data on sexual frequency show no significant increase in estimated frequency of sex since 1989, despite its strong appeal and the availability of new societal conveniences. This held both before and after adjustment for the age, marital status and education in the population; contrary to expectation, working long hours was associated with increased sex both before and after adjustment for these other demographic predictors. The SPPA trend data on arts participation actually showed a decline in participation, especially after adjustment for its major predictor of years of education; again no decreased participation was found among those working long hours. While scores on verbal ability in the GSS have stayed rather steady since 1974, they have decreased after MCA adjustment for the increased college education in more recent years, as documented by Nie et al. (2009). Thus, contrary to expectations, increases in public education have not been accompanied by improvements on these three indicators.     

Nanotechnology Risk Communication Past and Prologue

Nanotechnologies operate at atomic, molecular, and macromolecular scales, at scales where matter behaves differently than at larger scales and quantum effects can dominate. Nanotechnologies have captured the imagination of science fiction writers as science, engineering, and industry have leapt to the challenge of harnessing them. Applications are proliferating. In contrast, despite recent progress the regulatory landscape is not yet coherent, and public awareness of nanotechnology remains low. This has led risk researchers and critics of current nanotechnology risk communication efforts to call for proactive strategies that do more than address facts, that include and go beyond the public participation stipulated by some government acts. A redoubling of nanotechnology risk communication efforts could enable consumer choice and informed public discourse about regulation and public investments in science and safety.