Inference in Targeted Group‐Sequential Covariate‐Adjusted Randomized Clinical Trials

This article is devoted to the construction and asymptotic study of adaptive, group‐sequential, covariate‐adjusted randomized clinical trials analysed through the prism of the semiparametric methodology of targeted maximum likelihood estimation. We show how to build, as the data accrue group‐sequentially, a sampling design that targets a user‐supplied optimal covariate‐adjusted design. We also show how to carry out sound statistical inference based on such an adaptive sampling scheme (therefore extending some results known in the independent and identically distributed setting only so far), and how group‐sequential testing applies on top of it. The procedure is robust (i.e. consistent even if the working model is mis‐specified). A simulation study confirms the theoretical results and validates the conjecture that the procedure may also be efficient.     

A closed loop automatic scheduling system (CLASS)

Abstract

CLASS is a production scheduling system, that is designed to function in either a stand-alone manner, or in conjunction with an MRP system. MRP systems innately do not have 'closed loop’ capability in the sense of being able to produce master schedules and order releases that are consistent and that respect capacity constraints. True closed loop performance requires detailed scheduling. In addition to interfacing with MRP systems, CLASS is designed to produce schedules that can be used in conventional shops or can be downloaded to automated facilities. The design goals for the system, its internal architecture, and its role in manufacturing control systems are described. The modelling and decision capabilities     

Competence and consent to research: A critique of the recommendations of the national bioethics advisory commission*

Concern about the participation of incompetent subjects in psychiatric research has grown in the last several years. In response, the National Bioethics Advisory Commission (NBAC) recommended in its recent report that all investigations involving persons with mental disorders that may be associated with cognitive impairment that may pose greater than minimal risk to subjects utilize independent assessors to verify the capacities of subjects prior to entry into the study. This recommendation poses several problems for the conduct of research and the protection of research subjects. First, it fails to target that group of subjects most likely to be at risk for incapacity. Second, it focuses on too broad a range of research projects, many of which pose little risk to participants. The substantial costs of this approach are therefore not likely to be outweighed by concomitant benefits. In place of the NBAC recommendation, the author proposes a more flexible system of capacity assessment, designed to balance the costs with a greater likelihood of achieving meaningful protection for research subjects with mental disorders.     

A modified subset selection formulation with special reference to one-way and two-way layout experiments

The usual formulation of subset selection due to Gupta (1956) requires a minimum guaranteed probability of a correct selection. The modified formulation of the present paper includes an additional requirement that the expected number of the nonbest populations be bounded above by a specified constant when the best and the next best populations are ‘sufficiently’ apart. A class of procedures is defined and the determination of the minimum sample size required is discussed. The specific problems discussed for normal populations include selection in terms of means and variances, and selection in terms of treatment effects in a two-way layout.     

Unbiastld estimation of parametric functions in sampling from two two-truncation parameter families

We consider the problem of UMVU estimation of a U-estimable function of four unknown truncation parameters based on two independent random samples from two two-truncation parameter families. In particular, we obtain the UMVU estimator of functional, P (Y > X). Also the confidence intervals for some parametric functions are obtained.     

Recurrence relations for moments of different orders of extremes from gamma distribution

Certain recurrence relations for the moments of different orders of the largest order statistic from a gamma distribution with shape parameter p are obtained. By using this it is shown that for obtaining the moment of any order of each order statistic of a sample of size n from the gamma distribution, one has to evaluate at most n-2 single integrals.     

The Role of Criminal Social Identity in the Relationship between Criminal Friends and Criminal Thinking Style within a Sample of Recidivistic Prisoners

Previous research suggests a direct relationship between criminal friends and criminal thinking style; however, social identity theory proposes that identity mediates the impact of social group members on development of thinking styles. This research project is the first attempt to empirically test the mediating role of criminal social identity in the development of criminal thinking styles within a recidivistic prison sample (N = 312). The structural equation model of criminal thinking style presented and tested in this study supports the central predictions of social identity theory, with findings demonstrating an indirect effect of antisocial friend associations on criminal thinking through in-group affect and in-group ties with criminal in-group members that reflect two of three dimensions of the measure of criminal social identity applied in the current study. Further implications in relation to theory and previous studies are discussed.