Machine Learning Methods as a Tool for Predicting Risk of Illness Applying Next‐Generation Sequencing Data

Next‐generation sequencing (NGS) data present an untapped potential to improve microbial risk assessment (MRA) through increased specificity and redefinition of the hazard. Most of the MRA models do not account for differences in survivability and virulence among strains. The potential of machine learning algorithms for predicting the risk/health burden at the population level while inputting large and complex NGS data was explored with Listeria monocytogenes as a case study. Listeria data consisted of a percentage similarity matrix from genome assemblies of 38 and 207 strains of clinical and food origin, respectively. Basic Local Alignment (BLAST) was used to align the assemblies against a database of 136 virulence and stress resistance genes. The outcome variable was frequency of illness, which is the percentage of reported cases associated with each strain. These frequency data were discretized into seven ordinal outcome categories and used for supervised machine learning and model selection from five ensemble algorithms. There was no significant difference in accuracy between the models, and support vector machine with linear kernel was chosen for further inference (accuracy of 89% [95% CI: 68%, 97%]). The virulence genes FAM002725, FAM002728, FAM002729, InlF, InlJ, Inlk, IisY, IisD, IisX, IisH, IisB, lmo2026, and FAM003296 were important predictors of higher frequency of illness. InlF was uniquely truncated in the sequence type 121 strains. Most important risk predictor genes occurred at highest prevalence among strains from ready‐to‐eat, dairy, and composite foods. We foresee that the findings and approaches described offer the potential for rethinking the current approaches in MRA.     

‘Fuck It,Shit Happens (FISH)’: a social generations approach to understanding young people’s imaginings of life after school in 2016–2017

ABSTRACT

This article uses a social generations approach to explore the lives of young people transitioning to life after schooling. Drawing on ethnographic research in England during the geopolitical uncertainty of 2016–2017, we track the trajectories and narratives of six individuals. The research begins with final year pupils in schools talking about their futures, during and after their A-Level exams. We then follow these individuals on routes to Higher Education and employment, exploring how they are socialised into imaginings of the future and/or struggle to inhabit these futures. A deeply ingrained, modernist, neoliberal reckoning of future time is normalised through experiences of schooling. However, this logic is troubled profoundly in the transition to life after school. Young people’s experiences in an unpredictable present run in stark contrast to the ordered trajectory of future action they have been socialised to expect. Amidst this uncertainty, ambivalence towards shaping the future (‘Fuck It, Shit Happens’) can in some ways feel like the most agentic stance to take. Furlong et al.’s (2011) social generations approach to understanding youth transitions reveals how we must critique the very concept of ‘the future’ if we are to understand the reality of youth transitions in the present.     

Protest Camps and Repertoires of Contention

Protest camps have become a prominent feature of the post-2010 cycle of social movements and while they have gripped the public and media's imagination, the phenomenon of protest camping is not new. The practice and performance of creating protest camps has a rich history, which has evolved through multiple movements, from Anti-Apartheid to Anti-war. However, until recently, the history of the protest camp as part of the repertoire of social movements and as a site for the evolution of a social movement's repertoire has largely been confined to the histories of individual movements. Consequently, connections between movements, between camps and the significance of the protest camp itself have been overlooked. In this research profile, we argue for the importance of studying protest camps in relation to social movements and the evolution of repertoires noting how protest camps adapt infrastructures and practices from tent cities, festival cultures, squatting communities and land-based autonomous movements. We also acknowledge protest camps as key sites in which a variety of repertoires of contention are developed, tried and tested, diffused or sometimes dismissed. To facilitate the study protest camps we suggest a theory and practice of ‘infrastructural analysis’ and differentiated between four protest camp infrastructures: (1) media & communication, (2) action, (3) governance and (4) re-creation. We then use the infrastructures of media and communications as a brief example as to how our proposed infrastructural analysis can contribute to the study of repertoires and our understanding of the rich dynamics of a protest camp.     

What future for the Global Aid for Trade Initiative? Towards an assessment of its achievements and limitations

As with any form of contemporary global governance, the impact of the global Aid for Trade Initiative (2006) has been mixed. However, to dismiss it as a failure would be premature. The co‐ordination system established was based on best‐practice techniques of governance in a diverse non‐hierarchical environment, such as the international development community. This form of co‐operation cannot overcome global economic and political asymmetries, but it can be effective in several respects. In particular, the Initiative led to increased funding for AfT and kick‐started a range of initiatives and technical advances; while the monitoring process has evolved significantly to give voice to new actors and issues. Although the future of the AfT Initiative is uncertain, its achievements merit careful consideration.     

Replacing the Canadianization Generation: An Examination of Faculty Composition from 1977 through 2017

Amid growing numbers of doctoral graduates entering an increasingly competitive global academic job market, concerns about equity in the hiring process and the value of the Canadian Ph.D. are mounting. Grounded within the historical context of the Canadianization Movement, we examine the doctoral credentials of 4,934 U15 social science faculty between 1977 and 2017 to understand the ebb and flow of incoming and outgoing faculty across the country's academic field. Our trend analyses reveal an overall increase in the proportion of Canadian‐trained faculty hires with the noted exceptions of Canada's top three universities who display a strong presence of high‐status American‐trained faculty throughout. Results from the contemporary period, between 1997 and 2017, reveal a time of retirement during which outgoing Canadian‐trained faculty are replaced with increasing proportions of American‐trained academics.     

Children's and Adolescents' Decisions about Sharing Money with Others

Two hundred and ninety-four participants aged between 7 and 17 years of age were asked to share out money between themselves and another, imaginary group. Individual responses were recorded as well as responses after discussion in a group with two other participants. The distribution task took place in two different experimental conditions that either gave participants a free choice about how much to offer to the other group or involved making a strategic offer to avoid the other group rejecting an offer and losing all the money. From 10 years of age onwards, when allowed to choose freely how much to share, boys made progressively less generous offers than girls whereas girls' offers remained the same with age. However, when inter-group strategic constraints were present, there were few gender differences from 10 years of age. The order in which games were presented was a powerful influence on the offers that participants made.     

The Perceived Health Risks of Indoor Radon Gas and Overhead Powerlines: A Comparative Multilevel Approach

Radon and overhead powerlines are two radiation risk cases that have raised varying levels of concern among the general public and experts. Despite both involving radiation—a typically feared and unseen health hazard—individuals' perceptions of the two risk cases may invoke rather different factors. We examined individual and geographic-contextual factors influencing public perceptions of the health risks of indoor radon gas and overhead powerlines in a comparative research design, utilizing a postal questionnaire with 1,528 members of the general public (response rate 28%) and multilevel modeling techniques. This study found that beliefs about the two risk cases mainly differed according to the level of "exposure"—defined here in terms of spatial proximity. We argue that there are two alternative explanations for this pattern of findings: that risk perception itself varies directly with proximity, or that risk is more salient to concerned people in the exposed areas. We also found that while people living in high radon areas are more concerned about the risks of indoor radon gas, they find these risks more acceptable and have more trust in authorities. These results might reflect the positive effects of successive radon campaigns in high radon areas, which may have raised awareness and concern, and at the same time may have helped to increase trust by showing that the government takes the health risks of indoor radon gas seriously, suggesting that genuine risk communication initiatives may have positive impacts on trust in risk management institutions.     

Managing electronic documents and work flows: Enterprise content management at work in nonprofit organizations

Web management and knowledge management systems have made significant technological advances, culminating in large information management systems such as enterprise content management (ECM). ECM is a Web‐based publishing system that manages large numbers of electronic documents and other Web assets intended for publication to Web portals and other complex Web sites. Work in nonprofit organizations can benefit from adopting new communication technologies that promote collaboration and enterprisewide knowledge management. The unique characteristics of ECM are enumerated and analyzed from a knowledge management perspective. We identify three stages of document life cycles in ECM implementations—content, reification, and commodification/process—as the content management model. We present the model as a mechanism for decision makers and scholars to use in evaluating the organizational impacts of systems such as ECM. We also argue that decision makers in nonprofit organizations should take care to avoid overly commodifying business processes in the final stage, where participation may be more beneficial than efficiency.     

How Within-Study Comparisons can Inform Research and Evaluation Design for the Third Sector

VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Within-study comparisons (WSCs) compare quasi-experimental results to an experimental benchmark and assess the extent to...