Scalable module detection for attributed networks with applications to breast cancer

The objective of network module detection is to identify groups of nodes within a network structure that are tightly connected. Nodes in a network often have attributes (aka metadata) associated with them. It is often desirable to identify groups of nodes that are tightly connected in the network structure, but also have strong similarity in their attributes. Utilizing attribute information in module detection is a major challenge because it requires bridging the structural network with attribute data. A Weighted Fast Greedy (WFG) algorithm for attribute-based module detection is proposed. WFG utilizes logistic regression to bridge the structural and attribute spaces. The logistic function naturally emphasizes associations between attributes and network structure accordingly, and can be easily interpreted. A breast cancer application is presented that connects a protein–protein interaction network gene expression data and a survival outcome. This application demonstrates the importance of embedding attribute information into the community detection framework on a breast cancer dataset. Five modules were significant for survival and they contained known pathways and markers for cancer, including cell cycle, p53 pathway, BRCA1, BRCA2, and AURKB, among others. Whereas, neither the gene expression data nor the network structure alone gave rise to these cancer biomarkers and signatures.     

Working together: using group relations theory to understand and rethink the interplay between administrators and social work practitioners

This essay attempts to explain and theorise observable tensions between the roles of social work practitioner and administrator. It uses the psychoanalytic concepts of primary task and authority to draw attention to this under examined area. Employing illustrative vignettes from practice, it argues that a lack of integration between the roles leads to worker dissatisfaction and weakens service delivery. The essay then suggests that the false split between the roles of social worker and administrator is symptomatic of wider political policy in which public sector budget control is set in opposition to service user need and/or professional judgement. Taking inspiration from the work of Clare Winnicott, it calls for an integrated managerial system in which both roles are enabled to work together to develop common, service user orientated goals and practice.     

Separated Parents’ Adaptive Responses and States Within Intractable Parental Disputes

ABSTRACT

Drawing on interviews with separated parents (N = 40) this Australian qualitative study explored dissonance within intractable parental disputes. The mature defense mechanisms of altruism, suppression, anticipation, and humor emerged as potential adaptive responses to dissonance. The mature defense mechanism of sublimation did not emerge as a potential adaptive response to dissonance within intractable parental disputes. Anxiety was the predominant state reported by separated parents. This study theorized that mature defense mechanisms might partially support the reduction of recurring dissonant states within intractable parental disputes. Those in clinical practice might find it useful to explore defense mechanisms, and the clues they provide, in further understanding and supporting separated parents enmeshed within intractable parental disputes.     

Strengths and coping strategies in the life narratives of sexual minority women

This study explored self-described strengths and strategies for coping with stress among sexual minority women (SMW), drawing on qualitative narratives of sexual minority and heterosexual women who were recruited from a population-based sample. In-depth follow-up qualitative telephone interviews were conducted with 48 women who had participated in the National Alcohol Survey, a U.S. population-based survey. Participants included 25 SMW and 16 matched exclusively heterosexual women. Narrative data were analyzed using inductive thematic analysis and constant comparison to explore the study aim, with an emphasis on themes that diverged or that were particularly salient for SMW relative to heterosexual women. Strengths and coping strategies that were especially meaningful in the narratives of sexual minority women emerged in two areas. First, participants described development of intrapersonal strengths through nurturing an authentic sense of self and embracing multifaceted identity. Second, participants described multiple strategies for cultivation of interpersonal resources: navigating distance and closeness with family of origin, cultivating supportive friends and chosen family, connecting to community, finding solace and joy with animals, and engaging in collective action. Findings underscore the importance of considering protective factors that are salient to SMW in developing or refining prevention and intervention efforts.     

Social protection assessment‐based national dialogue exercises: Cambodia,Indonesia, Thailand,Viet Nam

Between 2011 and 2013, the International Labour Organization, in collaboration with governments and several United Nations agencies working as part of the Social Protection Floor Initiative, conducted social protection assessment‐based national dialogue (ABND) exercises in Cambodia, Indonesia, Thailand and Viet Nam. The exercises were carried out in order to take stock of existing social protection realities in the respective countries, including social insurance, social assistance and anti‐poverty programmes. These inventories present a comprehensive picture of what elements of national social protection floors (SPFs) are in place, where “holes” in national floors exist, and provide a framework within which to propose recommendations for the further design and implementation of social protection provisions that guarantee at least the SPF to the entire population. This article describes the methodology for conducting ABND exercises, the situational analysis of the SPF in four countries, and the policy recommendations that were formulated for achieving basic health care and income security for children, the working‐age population and the elderly. The results of preliminary calculations of the cost of implementing proposed policy options are also outlined.     

Critical Review and Uncertainty Analysis of Factors Influencing Influenza Transmission

Influenza remains a significant threat to public health, yet there is significant uncertainty about the routes of influenza transmission from an infectious source through the environment to a receptor, and their relative risks. Herein, data pertaining to factors that influence the environmental mediation of influenza transmission are critically reviewed, including: frequency, magnitude and size distribution and virus expiration, inactivation rates, environmental and self‐contact rates, and viral transfer efficiencies during contacts. Where appropriate, two‐stage Monte Carlo uncertainty analysis is used to characterize variability and uncertainty in the reported data. Significant uncertainties are present in most factors, due to: limitations in instrumentation or study realism; lack of documentation of data variability; or lack of study. These analyses, and future experimental work, will improve parameterization of influenza transmission and risk models, facilitating more robust characterization of the magnitude and uncertainty in infection risk.     

Selecting Nonpharmaceutical Interventions for Influenza

Models of influenza transmission have focused on the ability of vaccination, antiviral therapy, and social distancing strategies to mitigate epidemics. Influenza transmission, however, may also be interrupted by hygiene interventions such as frequent hand washing and wearing masks or respirators. We apply a model of influenza disease transmission that incorporates hygiene and social distancing interventions. The model describes population mixing as a Poisson process, and the probability of infection upon contact between an infectious and susceptible person is parameterized by p. While social distancing interventions modify contact rates in the population, hygiene interventions modify p. Public health decision making involves tradeoffs, and we introduce an objective function that considers the direct costs of interventions and new infections to determine the optimum intervention type (social distancing versus hygiene intervention) and population compliance for epidemic mitigation. Significant simplifications have been made in these models. However, we demonstrate that the method is feasible, provides plausible results, and is sensitive to the selection of model parameters. Specifically, we show that the optimum combination of nonpharmaceutical interventions depends upon the probability of infection, intervention compliance, and duration of infectiousness. Means by which realism can be increased in the method are discussed.     

Human and organizational factors in offshore safety

The role of human and organizational factors in predicting accidents and incidents has become of major interest to the UK offshore oil and gas industry. Some of these factors had been measured in an earlier study focusing on the role of risk perception in determining accident involvement. The current study sought to extend the methodology by focusing on perceptions of organizational factors that could have an impact on safety. A self-report questionnaire was developed and distributed to 11 installations operating on the UK Continental Shelf. A total of 722 were returned (33% response rate) from a representative sample of the offshore workforce on these installations. The study investigated the underlying structure and content of offshore employees' attitudes to safety, feelings of safety and satisfaction with safety measures. Correlations and step-wise regression analysis were used to test the relationships between measures. The results suggest that 'unsafe' behaviour is the 'best' predictor of accidents/near misses as measured by self-report data and that unsafe behaviour is, in turn, driven by perceptions of pressure for production.     

Adults in Wilderness Treatment: A Unique Application of Attachment Theory and Research

Research shows how an understanding of adult attachment applies to clinical treatment, such as outpatient therapy, but no literature explores the application of adult attachment to wilderness therapy, a distinct type of residential treatment. This paper explores how an understanding of adult attachment applies to wilderness therapy clients, as the nature of wilderness therapy involves losses, separations, and reunions, all of which evoke attachment needs. Adult wilderness treatment exemplifies an effective method of treatment that provides a secure base and supports healthy attachment relationships.     

Characterizing the Risk of Infection from Mycobacterium tuberculosis in Commercial Passenger Aircraft Using Quantitative Microbial Risk Assessment

Quantitative microbial risk assessment was used to predict the likelihood and spatial organization of Mycobacterium tuberculosis ( Mtb ) transmission in a commercial aircraft. Passenger exposure was predicted via a multizone Markov model in four scenarios: seated or moving infectious passengers and with or without filtration of recirculated cabin air. The traditional exponential ( k  = 1) and a new exponential ( k  = 0.0218) dose-response function were used to compute infection risk. Emission variability was included by Monte Carlo simulation. Infection risks were higher nearer and aft of the source; steady state airborne concentration levels were not attained. Expected incidence was low to moderate, with the central 95% ranging from 10⁻⁶ to 10⁻¹ per 169 passengers in the four scenarios. Emission rates used were low compared to measurements from active TB patients in wards, thus a "superspreader" emitting 44 quanta/h could produce 6.2 cases or more under these scenarios. Use of respiratory protection by the infectious source and/or susceptible passengers reduced infection incidence up to one order of magnitude.