The principle of double-effect in a clinical context

Whereas indirect euthanasia is a common clinical practice, active euthanasia remains forbidden in most countries. The reason for this differentiation is usually seen in the principle of double-effect (PDE). PDE states that there is a morally relevant difference between the intended consequences of an action and merely foreseen, unintended side-effects. This article discloses the fundamental assumptions presenting the basis for this application of the PDE and examines whether these assumptions are compatible with the PDE. It is shown that neither a liberal nor a utilitarian point of view makes the utilization of the PDE possible. In accordance with philosophical tradition, only within the doctrine of the sanctity of life does the PDE seem to be applicable. By analysing the premises of this doctrine, and comparing them with those of the PDE, the inconsistency of this idea is demonstrated. It is suggested that the role of the PDE in the current discussion on euthanasia is largely exaggerated. Electronic Publication     

Income determination for corporate tax purposes using IFRS as a starting point: evidence for listed companies within Austria, Germany, and The Netherlands

The internationalisation of financial accounting and the European Commission’s ambition to harmonise corporate taxation have raised the question whether IFRS accounts could be used for tax purposes. In order to quantify the effects of an IFRS-based taxation on corporate tax burdens in different EU member states, we estimate firms’ tax equity using notes on income taxes in IFRS financial statements of companies listed in Austria, Germany, and The Netherlands. The difference between estimated tax equity and IFRS-equity, adjusted for the effect resulting from the recognition of deferred taxes, shows the effect of using IFRS as a tax base on the present value of corporate taxes. We find that estimated tax equity is mostly lower than IFRS-equity, indicating that an IFRS-based taxation would often increase the present value of corporate taxes. The median of estimated tax equity is 5.6 % (Austria), 6.4 % (Germany) and 9.0 % (The Netherlands) below IFRS-equity. However, an IFRS-based taxation does not always induce higher equity as often argued in the literature. In 307 of 1,113 totally analysed firm-years, estimated tax equity exceeds IFRS-equity. To find a further estimation for the effects of tax base reforms we also approximate the total stock of unused tax losses and the amount of useable tax losses. We find that deferred tax assets for unused tax losses are depreciated to a substantial extent.     

Feasibility Study on the Use of Probabilistic Migration Modeling in Support of Exposure Assessment from Food Contact Materials

The use of probabilistic approaches in exposure assessments of contaminants migrating from food packages is of increasing interest but the lack of concentration or migration data is often referred as a limitation. Data accounting for the variability and uncertainty that can be expected in migration, for example, due to heterogeneity in the packaging system, variation of the temperature along the distribution chain, and different time of consumption of each individual package, are required for probabilistic analysis. The objective of this work was to characterize quantitatively the uncertainty and variability in estimates of migration. A Monte Carlo simulation was applied to a typical solution of the Fick's law with given variability in the input parameters. The analysis was performed based on experimental data of a model system (migration of Irgafos 168 from polyethylene into isooctane) and illustrates how important sources of variability and uncertainty can be identified in order to refine analyses. For long migration times and controlled conditions of temperature the affinity of the migrant to the food can be the major factor determining the variability in the migration values (more than 70% of variance). In situations where both the time of consumption and temperature can vary, these factors can be responsible, respectively, for more than 60% and 20% of the variance in the migration estimates. The approach presented can be used with databases from consumption surveys to yield a true probabilistic estimate of exposure.     

The impact of tax uncertainty on irreversible investment

Traditional models of capital budgeting with taxes are based on deterministic tax rates and tax bases. In reality, however, there are multiple sources of tax uncertainty. Frequent tax reforms make future taxation of investments a stochastic process. Fiscal authorities and tax courts create additional tax uncertainty by interpreting current tax laws differently. Moreover, simplified models that anticipate the actual tax base incorrectly contribute to tax uncertainty as perceived by investors. I analyze the effects of stochastic taxation on investment behavior in a real options model. The investor holds an option to invest in an irreversible project with stochastic cash flows and stochastic tax payments. Pre-tax cash flows and tax payments are assumed to be correlated. Increased tax uncertainty has an ambiguous impact on investment timing. For low tax uncertainty, high cash flow uncertainty and high correlation of cash flows and tax payments, increased tax uncertainty is likely to accelerate investment. A higher expected tax payment delays investment. A higher after-tax discount rate affects investment timing ambiguously.     

Optimal design for quasi-likelihood estimation in Poisson regression with random coefficients

Count data may be described by a Poisson regression model. If random coefficients are involved, maximum likelihood is not feasible and alternative estimation methods have to be employed. For the approach based on quasi-likelihood estimation a characterization of design optimality is derived and optimal designs are determined numerically for an example with random slope parameters.     

Reported Happiness,Fast and Slow

The paper uses paradata on response time, cognitive effort and questionnaire order from a large Dutch internet panel survey to study the association between reporting process and reported happiness. We find that slower responses and higher self-stated cognitive effort are associated with lower reported happiness, potentially, because they proxy for momentary mood. Moreover, in multivariate happiness equations, these factors moderate the estimated effect of income on happiness, while no interaction effects are found for other socio-economic determinants of happiness. Our findings have implications for the interpretation of relative marginal effects in economic happiness equations.     

The ‘Failed State Index’ Offers More than Just a Simple Ranking

The role of indicators to measure trends in every area of interest is increasing. Especially in the field of politics and sociology, where modeling based on multiple indicators typically is difficult, multi-indicator systems call for attention. Multi-indicator systems are most often the first step to derive a ranking indicator. Correspondingly there is a high interest in how to transform multi-indicator systems into a one-dimensional metric scale. The scientific discipline of decision support systems provides many well-known techniques, classical examples are PROMETHEE, ELECTRE, DEA or the simple TOPSIS. The mathematical technique is pretty sophisticated, therefore the simplest variant, namely the weighted sum of indicators plays its role too, just because of its simplicity and transparency. Although the need of a derivation of a one-dimensional scale is evident, we argue that there is an interim step, between the multi-indicator system and the ranking index, provided by simple elements of partial order theory. This interim step bears useful information too and in this paper we show how and which useful additional information can be derived. We derive for example a bias-free sensitivity study, where the indicator “chronic and sustained human flight” turns out to be the most important indicator within the multi-indicator system of 12 indicators, which are the basis of the Failed State Index.