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81.
Ríos-Chelén Alejandro Ariel Cuatianquiz-Lima Cecilia Bautista Amando Martínez-Gómez Margarita 《Urban Ecosystems》2018,21(1):15-25
Urban Ecosystems - Vermilion flycatchers, a suboscine, sing songs with more elements in territories with higher urban noise levels. We tested the hypothesis that this pattern is achieved through... 相似文献
82.
Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation
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Margaret Gamalo‐Siebers Jasmina Savic Cynthia Basu Xin Zhao Mathangi Gopalakrishnan Aijun Gao Guochen Song Simin Baygani Laura Thompson H. Amy Xia Karen Price Ram Tiwari Bradley P. Carlin 《Pharmaceutical statistics》2017,16(4):232-249
Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics. 相似文献
83.
Emilio Gómez–Déniz 《统计学通讯:理论与方法》2017,46(18):9007-9025
In this paper, we assume that the duration of a process has two different intrinsic components or phases which are independent. The first is the time it takes for a trade to be initiated in the market (for example, the time during which agents obtain knowledge about the market in which they are operating and accumulate information, which is coherent with Brownian motion) and the second is the subsequent time required for the trade to develop into a complete duration. Of course, if the first time is zero then the trade is initiated immediately and no initial knowledge is required. If we assume a specific compound Bernoulli distribution for the first time and an inverse Gaussian distribution for the second, the resulting convolution model has a mixture of an inverse Gaussian distribution with its reciprocal, which allows us to specify and test the unobserved heterogeneity in the autoregressive conditional duration (ACD) model.
Our proposals make it possible not only to capture various density shapes of the durations but also easily to accommodate the behaviour of the tail of the distribution and the non monotonic hazard function. The proposed model is easy to fit and characterizes the behaviour of the conditional durations reasonably well in terms of statistical criteria based on point and density forecasts. 相似文献
84.
In this paper, we present a multivariate version of the skewed log-Birnbaum–Saunders regression model. This new family of distributions holds good properties such as marginal variables following univariate skewed log-Birnbaum–Saunders distributions, besides presenting the usual log-Birnbaum–Saunders distribution as a particular case. Furthermore, the model parameters are estimated through maximum-likelihood methods, a closed-form expression for the Fisher’s information matrix is presented, and testing hypothesis for model parameters is performed. Two real datasets are analyzed and results are discussed. 相似文献
85.
Guillermo Julián-Moreno Jorge E. López de Vergara Iván González Luis de Pedro Javier Royuela-del-Val Federico Simmross-Wattenberg 《Statistics and Computing》2017,27(5):1365-1382
\(\alpha \)-Stable distributions are a family of probability distributions found to be suitable to model many complex processes and phenomena in several research fields, such as medicine, physics, finance and networking, among others. However, the lack of closed expressions makes their evaluation analytically intractable, and alternative approaches are computationally expensive. Existing numerical programs are not fast enough for certain applications and do not make use of the parallel power of general purpose graphic processing units. In this paper, we develop novel parallel algorithms for the probability density function and cumulative distribution function—including a parallel Gauss–Kronrod quadrature—, quantile function, random number generator and maximum likelihood estimation of \(\alpha \)-stable distributions using OpenCL, achieving significant speedups and precision in all cases. Thanks to the use of OpenCL, we also evaluate the results of our library with different GPU architectures. 相似文献
86.
Lower female lifetime labour market participation rates, greater interruptions during their working lives, and wage gaps contribute to create gender gaps in pensions at the time of retirement. The design of social security systems may reinforce or attenuate these gaps. This article provides new evidence on gender gaps in access to pensions and in pension income in four Southern Cone countries in Latin America and analyses their evolution between 2000 and 2013, showing significant improvements in both gaps, with differential patterns by countries. The decrease in the gender gap in pension income has been particularly significant in Argentina and Brazil. In both cases, the largest increases in pension values during the period correspond to the lowest income percentiles, where women are overrepresented. The application of redistributive policies in these countries, aimed at reducing poverty and inequality but not necessarily focused on gender equity, has had positive and probably unintended consequences in terms of reduction in gender gaps in pensions. 相似文献
87.
88.
Racial/ethnic and socio‐economic biases in child maltreatment severity assessment in Spanish child protection services caseworkers
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Ignacia Arruabarrena Joaquín de Paúl Silvia Indias Mikel García 《Child & Family Social Work》2017,22(2):575-586
Evidence from several countries has shown the over‐representation of racial/ethnic minority groups in child protection services (CPS). The objective of the present study was to explore whether racial/ethnic and socio‐economic biases influence Spanish CPS caseworkers' judgements of the severity of child maltreatment. Moreover, the study attempted to explore the influence on these judgements of the use of structured instruments and professional experience. Two case vignettes of child maltreatment were presented to 405 CPS caseworkers and 169 students of social work and psychology. Family ethnic origin and income were manipulated in the vignettes. The findings showed no statistical evidence of biases related to family ethnic origin or socio‐economic status (SES) in Spanish CPS caseworkers' judgements of maltreatment severity. Biases related to family SES were found for students for the vignettes of physical abuse. CPS caseworkers and students who did not use a structured instrument to assess maltreatment severity tended to underestimate the severity for the vignettes of parental incapacity to control child/adolescent behaviour and to overestimate it for the vignettes of physical abuse. CPS caseworkers who used a structured instrument showed higher percentages of accuracy and inter‐rater agreement, supporting the relevance of structured tools in reducing potential caseworkers' biases. 相似文献
89.
Perceptions of grandparents who provide auxiliary care: value transmission and child‐rearing practices
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Cristina Noriega Javier López Roberto Domínguez Cristina Velasco 《Child & Family Social Work》2017,22(3):1227-1236
A grounded theory qualitative study was developed to explore how grandparents perceive their role as socializing agents. Forty‐two grandparents with grandchildren aged from 6 to 12 years old participated in this study. Data were collected through focus groups, which were conducted until reaching data saturation and analyzed using the constant comparative method. Four general conclusions emerged from the study: (i) grandparents recognized the importance of getting involved in the socialization of grandchildren as supporters of parents' socializing role, and the need to adapt to social changes; (ii) they emphasized traditional value that were perceived in decline, and combination of warmth and involvement were considered the best way to help grandchildren internalize values; (iii) interaction with grandchildren helped grandparents to feel active and useful, increased their life purpose and gave them a second chance to enjoy what they could not with their own children; and (iv) grandparents also accused burden and role ambiguity. These results show the importance of developing family policies that recognize grandparents' socializing role. Also, interventions that promote strategies that enable grandparents to perform their role more successfully and to cope with possible family conflicts should be developed. 相似文献
90.
Esperanza León Jesús M. Jiménez‐Morago Alicia Muñoz‐Silva 《Child & Family Social Work》2017,22(2):1075-1083
Within the context of kinship care, the main objectives of this work are to study the characteristics of contact between foster children and their birth parents, and their relationship with key variables of fostering, the children and their kinship caregivers. The sample included 189 children from Spain and their kinship families. A semi‐structured placement interview and two scales relating to the child–caregiver relationship and child's psychological adjustment were used with the kinship families. The results revealed a significant percentage of foster children who had no family contact. Various visit types, frequencies and durations were described. Kinship care with contact, compared with placements without contact, was frequently characterized by the absence of professional supervision, and an affectionate child–caregiver relationship; moreover, children with contact were perceived to have fewer serious behaviour and socio‐emotional problems and a greater probability of family reunification. The regression analysis showed that the main predictors for how caregivers assessed contact were the children's emotional reaction during visits and the quality of the relationship between the kinship families and the birth parents. These results suggest the need for further research about contact, which will certainly have a major impact on professional intervention with these families. 相似文献