Adaptive designs for best treatment identification with top-two Thompson sampling and acceleration

We consider outcome adaptive phase II or phase II/III trials to identify the best treatment for further development. Different from many other multi-arm multi-stage designs, we borrow approaches for the best arm identification in multi-armed bandit (MAB) approaches developed for machine learning and adapt them for clinical trial purposes. The best arm identification in MAB focuses on the error rate of identification at the end of the trial, but we are also interested in the cumulative benefit of trial patients, for example, the frequency of patients treated with the best treatment. In particular, we consider Top-Two Thompson Sampling (TTTS) and propose an acceleration approach for better performance in drug development scenarios in which the sample size is much smaller than that considered in machine learning applications. We also propose a variant of TTTS (TTTS2) which is simpler, easier for implementation, and has comparable performance in small sample settings. An extensive simulation study was conducted to evaluate the performance of the proposed approach in multiple typical scenarios in drug development.     

Effect of length-biased sampling on the modeling error

In statistical data analysis, the choice of an appropriate model is a very important factor. An inappropriate model leads to a different kind of error in the analysis. This error has been called by C. R. Rao as type III error or modeling error as opposed to type I and type II errors in statistical inference.In This paper we Study the relative errors in Incurred by Erroneously Assuming the Distribution of the Family Size N as P(n) While in fact it is the Length-biased (Weighted) Version of P(n).An Analytical Expression for the Relative Error,When the Distribution of N Belongs to the Class of Modified Power Series Distributions, is Derived. More Specifically, the Effect of length-biasing on the Relative Error is Investigated, When N Follows a Generalized Poisson Distribution. These Results are Compared With the Case When N Follows a Poisson Distribution.     

Mantel test for spatial functional data

Statistics for spatial functional data is an emerging field in statistics which combines methods of spatial statistics and functional data analysis to model spatially correlated functional data. Checking for spatial autocorrelation is an important step in the statistical analysis of spatial data. Several statistics to achieve this goal have been proposed. The test based on the Mantel statistic is widely known and used in this context. This paper proposes an application of this test to the case of spatial functional data. Although we focus particularly on geostatistical functional data, that is functional data observed in a region with spatial continuity, the test proposed can also be applied with functional data which can be measured on a discrete set of areas of a region (areal functional data) by defining properly the distance between the areas. Based on two simulation studies, we show that the proposed test has a good performance. We illustrate the methodology by applying it to an agronomic data set.     

Lot‐sizing Decisions Under Limited‐time Price Reduction*

We consider the optimal lot‐sizing policy for an inventoried item when the vendor offers a limited‐time price reduction. We use the discounted cash flow (DCF) approach in our analysis, thereby eliminating the sources of approximation found in most of the earlier studies that use an average annual cost approach. We first characterize the optimal lot‐sizing policies and their properties, then develop an algorithm for determining the optimal lot sizes. We analytically demonstrate that the lot sizes derived using an average annual cost approach for the different variants of the problem are, in general, larger than the DCF optimum. While DCF analysis is more rigorous and yields precise lot sizes, we recognize that the associated mathematical models and the solution procedure are rather complex. Since simple and easy‐to‐understand policies have a strong practical appeal to decision makers, we propose a DCF version of a simple and easy‐to‐implement heuristic called the “Early Purchase” (EP) strategy and discuss its performance. We supplement our analytical developments with a detailed computational analysis and discuss the implications of our findings for decision making.     

A Comparison of Selected Artificial Neural Networks that Help Auditors Evaluate Client Financial Viability

This study compares the performance of three artificial neural network (ANN) approaches—backpropagalion, categorical learning, and probabilistic neural network—as classification tools to assist and support auditor's judgment about a client's continued financial viability into the future (going concern status). ANN performance is compared on the basis of overall error rates and estimated relative costs of misclassificaticn (incorrectly classifying an insolvent firm as solvent versus classifying a solvent firm as insolvent). When only the overall error rate is considered, the probabilistic neural network is the most reliable in classification, followed by backpropagation and categorical learning network. When the estimated relative costs of misclassification are considered, the categorical learning network is the least costly, followed by backpropagation and probabilistic neural network.     

A FUZZY SUBSET CHARACTERIZATION OF A SITE-SELECTION PROBLEM

This paper presents an application of fuzzy subsets to the problem of selecting sites for locating gas stations. Cost minimization and profit maximization models represent typical approaches to location decisions. These approaches are not well-suited to problems like site selection for gas stations because of the difficulty in identifying precise relationships, the uncertainties involved, and the qualitative and imprecise nature of much of the information used for decision making. This paper proposes the use of a model based on linguistic variables and a direct evaluation of the available alternatives via the use of fuzzy variables. Conclusions regarding the practical advantages and limitations of the approach are drawn based on the reported application.