A comparative study of confidence intervals to assess biosimilarity from analytical data

Assessment of analytical similarity of tier 1 quality attributes is based on a set of hypotheses that tests the mean difference of reference and test products against a margin adjusted for standard deviation of the reference product. Thus, proper assessment of the biosimilarity hypothesis requires statistical tests that account for the uncertainty associated with the estimations of the mean differences and the standard deviation of the reference product. Recently, a linear reformulation of the biosimilarity hypothesis has been proposed, which facilitates development and implementation of statistical tests. These statistical tests account for the uncertainty in the estimation process of all the unknown parameters. In this paper, we survey methods for constructing confidence intervals for testing the linearized reformulation of the biosimilarity hypothesis and also compare the performance of the methods. We discuss test procedures using confidence intervals to make possible comparison among recently developed methods as well as other previously developed methods that have not been applied for demonstrating analytical similarity. A computer simulation study was conducted to compare the performance of the methods based on the ability to maintain the test size and power, as well as computational complexity. We demonstrate the methods using two example applications. At the end, we make recommendations concerning the use of the methods.     

INTERNATIONAL TRADE AND LABOR‐MARKET DISCRIMINATION

Discrimination reduces the matching probability and output in the skill‐intensive differentiated‐product sector so that discrimination‐induced comparative advantage may overshadow technological comparative advantage in determining the pattern of trade. Trade liberalization generates a decrease in the skilled‐worker wage gap in the country that is an exporter of goods from the simple sector but increases it in the country that is a net exporter of differentiated products. Trade liberalization has an opposite effect on firms. In the country that is an exporter of simple goods, trade liberalization reduces the profits of the nondiscriminatory firms by more than those of the discriminatory firms. (JEL F16, F66, J71)     

Viral video ‘blood chocolate’ activism,millennial anti-trafficking,and the neoliberal resurgence of shaming

Viral videos offer contemporary activists a nimble, provocative tool with which to disseminate humanitarian messages. This article historicizes anti-trafficking video media that imagine a new potential with which to alter behavioral norms around cocoa and chocolate. The article engages theories and approaches to historical and contemporary modalities of naming and shaming, spanning three centuries to the present day. Videos are examined for style, format, and content, with the view to describing a ‘blood chocolate’ visual and textual metonymy. Recurring themes include transnational power, corporate responsibility, and the horrific scale of exploitation. But viral videos also appear deeply influenced by neoliberal economics that celebrate lawful enterprise and promote consumer-driven solutions to exploitative child labor.     

Relationship of bird richness,abundance and assemblage to the built environment in a small island tropical urban setting: a Suva,Fiji case study

There have been few studies investigating the relationship between the built environment and the status of bird distributions in small island tropical urban areas. We present a study investigating the relationship between bird species richness, abundance and assemblage to the built environment in Suva, Fiji. Field surveys were taken at 54 randomly selected sites throughout the city, stratified by three building density classes and the central business district (CBD). At each site bird counts were recorded, along with environmental data such as average building height, within a 150 m radius. Land-use information was obtained from screen digitized high-resolution satellite imagery within the same radius. Distance to undeveloped patches of land within the urban area was calculated using a GIS. Analysis of the effects of the built environment was carried out for all species, and for exotic and native species separately. Abundance of exotics was significantly higher in the central business district (CBD) than all other urban density classes, and significantly higher than natives in all other density classes. We found a negative relationship between native species richness and distance to undeveloped patches, but no relationship for exotics. Species assemblage was not related to urban density class. We conclude that the status of native and exotic bird species in Suva is similar to what has been found in urban areas in temperate climates, and conservation efforts should focus on minimizing the amount of heavily urbanized “core areas” and protecting undeveloped areas of forested vegetation to improve bird biodiversity in small tropical islands cities.

     

Vegetation on and around large-scale buildings positively influences native tropical bird abundance and bird species richness

High population growth in the tropics is driving urbanisation, removing diverse natural ecosystems. This is causing native species to suffer while introduced synanthropes flourish. City planners are developing urban greenspace networks, in part trying to address this issue. Architects contribute to these greenspace networks by designing elevated and ground level green spaces on large-scale buildings. However, little evidence is available on whether building green spaces support native fauna. This is true for birds in tropical Singapore that support important ecosystem services and have existence value. Therefore, in this study, we conducted bird surveys and statistical analyses to determine, if and how vegetation on three building green space types (ground gardens, roof gardens and green walls) have a positive impact on native or introduced bird species. We found that elevated greenery (roof gardens and green walls) on large-scale buildings supported a higher richness of birds and abundance of urban native birds than control roofs and walls without vegetation. Ground gardens supported similar levels of native species as roof gardens but also a larger proportion of generalist synanthropes. However, we found no tropical forest habitat specialists across any space type. Therefore, we recommend roof gardens and ground gardens as a potential space for urban natives outside of a less competitive ground-level urban environment. Our study also found certain building design elements (height of elevated space, presence of specific plants) supported different species groups. Therefore, we suggest that these ecological requirements for different species groups are considered when designing a building’s green space.

     

Life Balance and Work Addiction Among NCAA Administrators and Coaches

Intercollegiate athletics represent an industry prone to challenges of work addiction and life balance. Work addiction and life balance domains in male and female intercollegiate athletic coaches and administrators (N = 245) were examined using multiple regression analysis. Higher levels of stress/anxiety, sleep disturbance, and career satisfaction and lower levels of quality of relationships and friendships were the strongest predictors of work addiction. Counseling focused on reducing the negative aspects of work addiction, while maintaining job performance, may benefit this population.     

ASSESSING ENVIRONMENTAL SCANNING AT THE SUBUNIT LEVEL: A MULTITRAIT-MULTIMETHOD ANALYSIS*

Environmental scanning activities of over 400 top management subunits in 108 European manufacturing firms provided the data base for this research. Four traits (constructs) of scanning using three methods (interest, frequency, and time) were examined. A confirmatory factor analysis approach to multitrait-multimethod (MTMM) data was employed. Verification of the reliability as well as convergent and discriminant validity of the scanning scales are reported and discussed. The viability of confirmatory factor analysis in providing a precise analysis of partitioning variance according to trait, method, and error is demonstrated.     

MARKET PENETRATION AND LOCATIONAL CONFLICT IN FRANCHISE SYSTEMS*

This paper addresses the questions of market penetration and locational conflict in a franchise system of distribution. The models developed provide a means to evaluate alternative scenarios and the effects of various franchise policies. It is shown that the market penetration and location goals of the members of a franchise system coincide only under a very limited set of circumstances.     

Population Measures of Subjective Wellbeing: How Useful are they?

This article focuses on the contributions and, importantly, the limitations of subjective wellbeing (happiness/satisfaction) measures as indicators of broad population wellbeing and societal functioning. The popular practice of comparing happiness among countries gives a skewed view of how well their people are faring. Charting trends over time in happiness and mental health gives contradictory pictures of population wellbeing; even the responses to different questions within the same survey can yield very different findings. Asking people about their own lives and about social conditions produces contrasting results. These issues challenge the orthodox model of human development, which places Western liberal democracies at its leading edge. According to an alternative, psychosocial-dynamics, model, some, at least, may be societies in decline. Reconciling these views is no simple matter.     

Racial Disparities in Early Criminal Justice Involvement

Criminologists have long reported the existence of racial disparity in the criminal justice system, but the important question is why. While some argue that observed differences are a consequence of more criminal behavior among minorities, the weight of the evidence indicates that this is but a partial explanation. In this paper, we study data from a sample of juveniles to examine how racial differences in early police contact, and important social environments—family, school, and neighborhoods—affect later contact and arrests, controlling for self-reported delinquency. We find that early (in middle school) contact with police is an important predictor of later (high school) arrests. Also we found that, in addition to being male and living in a low-income family, children who have parents who have a history of arrest, who have experienced school disciplinary actions, who have delinquent peers, and who are in networks with deviant adults are more likely to have problems with law enforcement. These factors help to explain racial differences in police contacts and arrests.