Physiologically Based Liver Modeling and Risk Assessment

Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments.     

Engineered Migration and the Use of Refugees as Political Weapons: A Case Study of the 1994 Cuban Balseros Crisis

This paper presents a case study of the August 1994 Cuban balseros crisis, during which more than 35,000 fled the island and headed toward Florida in the span of a few weeks. It argues that Castro launched the crisis in an attempt to manipulate US fears of another Mariel, and in order to compel a shift in US policy, both on immigration and on a wider variety of issues. The paper further contends that from Castro’s perspective, this exercise in coercion proved a qualified success – his third such successful use of the Cuban people as an asymmetric political weapon against the US. In addition, the paper argues that Castro’s success was predicated on his ability to internationalize his own domestic crisis and transform it into an American domestic political and foreign policy crisis. Finally, it offers a novel explanation of how, why, and under what conditions, states and/or non–state actors may attempt to use refugees as coercive political weapons. Although dwarfed in size by the larger 1980 Mariel boatlift, the 1994 crisis is important for several reasons. First, despite its brevity, it had far reaching consequences for US–Cuban relations. Without warning or preamble, it catalyzed a shift in US policy vis–à–vis Cuban immigration that represented a radical departure from what it had been for the previous three decades. Second, it influenced US domestic politics on the national level, by expanding the scope and salience of the issue, and mobilizing not only Floridians, but also the larger public concerned about illegal immigration. Third, the crisis illustrated the potential potency of engineered migration as an asymmetric weapon of the weak. Finally, the brief, but significant, interactions of international and domestic actors in this case warrant examination because, although the 1994 crisis was limited, in its dynamics it resembles myriad other international refugee crises, large and small. Thus the case offers valuable lessons that may aid in dealing with future (real or threatened) crises.     

Why the TVA Remains Unique: Interest Groups and the Defeat of New Deal River Planning*

Abstract Although scholars cite the Tennessee Valley Authority as one of President Franklin Roosevelt's major reform programs, the valley authority model did not replace the limited‐purpose water programs of the Bureau of Reclamation and the Army Corps of Engineers. State‐centered theorists hold that reformers are most likely to succeed during periods such as the New Deal era, when they are supported by a democratized polity and when they dominate Congress and the administration. This paper shows that in river policy, the strength of opposing interest groups also mattered. The TVA bill was passed in 1933 because reformers skillfully coordinated action at potential choke points and weakened the already disorganized opposing lobbyists. In 1936, however, after regrouping, opposing river lobbyists and legislators took advantage of the New Dealers' spending mood by expanding the Corps' flood control program. They also helped defeat further valley authorities, the most promising of the New Deal water policy reforms.     

Mining the Data: Analyzing the Economic Implications of Mining for Nonmetropolitan Regions

Extractive industries such as logging and mining are generally expected to bring significant economic benefits to rural regions, but a growing number of findings have now challenged that common expectation. Still, it is not clear whether the findings of less–than–desirable economic outcomes are isolated or representative. In this article, we assemble literally all of the relevant quantitative findings on mining that we have been able to identify in published and/or technical literature from the United States. In the interest of rigor, we limit the assessment to cases in which strictly nonmetropolitan mining regions are compared against other nonmetropolitan regions and/or against those regions’ own experiences over time. Overall, 301 findings meet the criteria for inclusion. Contrary to the long–established assumptions, but consistent with more recent critiques, roughly half of all published findings indicate negative economic outcomes in mining communities, with the remaining findings being split roughly evenly between favorable and neutral/indeterminate ones. Positive findings are more likely to be associated with incomes than with poverty or (especially) unemployment rates, and they are more likely to come from the western United States, where much of the mining involves relatively large, new coal strip mines. Over half of all positive findings come from the years prior to 1982. In virtually all other categories, the plurality or majority of findings have been negative. When the patterns of findings are subjected to one–sample means tests, the only way to produce a significantly positive outcome is by combining all neutral/indeterminate findings with the positive ones, while focusing exclusively on incomes; by contrast, in the case of poverty or unemployment rates—as well as for the overall body of findings—the results are consistently and significantly negative, whether the neutral/indeterminate findings are combined with negative ones or omitted from the equations altogether. Until or unless future studies produce dramatically different findings, there appears to be no scientific basis for accepting the widespread, “obvious” assumption that mining will lead to economic improvement.     

Acknowledgment of outside reviewers for 1994

Acknowledgment of outside reviewers for 1994     

In Whose Backyard?: Concern About Siting a Nuclear Waste Facility*

Proponents of hazardous and nuclear waste depositories label opponents to local siting of such facilities “NIMBYs” (Not In My Backyard). This study assesses the extent to which the NIMBY label and the strategies of industry proponents to reduce opposition function on a reasonable set of assumptions. Using survey data and multiple regression techniques, the levels of concern of residents living in the county selected as the site of a low level radioactive waste disposal facility (imminent threat condition) are compared with a statewide sample (hypothetical threat condition). Consistent with proponents' theoretical assumptions, the levels of concern are greater for respondents under conditions of imminent threat than of hypothetical threat. However, within the host county, levels of concern are lowest, albeit most polarized, in the community closest to the proposed site. A conflict theory approach enhances an understanding of these findings by suggesting that within the most proximate community levels of concern are lowest for citizens who stand to gain the most economic benefits from the facility but highest for those citizens who are least likely to derive tangible gains.     

Marital Conflict,Ineffective Parenting,and Children's and Adolescents' Maladjustment

Data from the 1988 National Survey on Families and Households were analyzed to examine the associations among marital conflict, ineffective parenting, and children's and adolescents' maladjustment. Parents' use of harsh discipline and low parental involvement helped explain the connection between marital conflict and children's maladjustment in children aged 2 through 11. Parent‐child conflict was measured only in families with a target teenager and also was a significant mediator. Although ineffective parenting explained part of the association between marital conflict and children's maladjustment, independent effects of marital conflict remained in families with target children aged 2 through 11 (but not for families with a teenager). With a few exceptions, this pattern of findings was consistent for mothers' and fathers' reports, for daughters and sons, for families with various ethnic backgrounds, and for families living in and out of poverty.     

Hearts and Minds and Morality: Analyzing Moral Vocabularies in Qualitative Studies

A strategy of analyzing the moral vocabulary of a social movement or subculture is proposed by which ethnographies and other qualitative works may place the moral and ethical concepts used by respondents into a broader sociological context. Through examining the moral resources, the status hierarchy which the specific moral resources within a given moral vocabulary form, and the historical and cultural contexts within which these moral resources exist, it is argued that it becomes possible to analyze and anticipate the moral claims and form of discourse which will be produced by a specific movement and/or subculture. It is also argued that this method may be used to predict how the opposition to a movement and/or subculture is perceived through the formation of an antithetical moral vocabulary.     

Struggling With Two Identities: The Case of Eileen

In this article, the authors present a case example of a Chinese American lesbian woman who seeks counseling for career decision making. The client's career issues stem from cultural issues that have created a dichotomy in her life. Using an ecological model, the authors dissect the case, propose interventions, and identify potential problems that may arise.